{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T02:29:27Z","timestamp":1777516167860,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Child Neurology Open"],"published-print":{"date-parts":[[2017,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Tuberous sclerosis complex is expressed throughout the body, resulting in a range of clinical manifestations that can be challenging to manage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The authors report a patient who presented at age 3.5 years with several suspected seizures and was diagnosed with tuberous sclerosis complex following the discovery of numerous bilateral cortical tubers and subependymal nodules on magnetic resonance imaging. Interdisciplinary, comprehensive care was recommended; this included ongoing surveillance to monitor for the development of tuberous sclerosis complex\u2013associated conditions. Approximately 2 years later, the patient began exhibiting aggressive and self-injurious behavior, and a subependymal giant cell astrocytoma was discovered. After everolimus was initiated, he demonstrated less aggression, had ceased self-injurious behavior, and subependymal giant cell astrocytoma growth stabilized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This case highlights the importance of a multidisciplinary approach to care in tuberous sclerosis complex, which ensures the early detection and appropriate treatment of clinical manifestations that may arise during the course of the patient\u2019s life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2329048x17725609","type":"journal-article","created":{"date-parts":[[2017,8,22]],"date-time":"2017-08-22T03:22:21Z","timestamp":1503372141000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Implementing a Multidisciplinary Approach to Treating Tuberous Sclerosis Complex"],"prefix":"10.1177","volume":"4","author":[{"given":"Tanjala T.","family":"Gipson","sequence":"first","affiliation":[{"name":"Tuberous Sclerosis Center of Excellence, Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Poretti","sequence":"additional","affiliation":[{"name":"Section of Pediatric Neuroradiology, Division of Pediatric Radiology, Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA"},{"name":"Deceased March 20, 2017."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,8,22]]},"reference":[{"key":"bibr1-2329048X17725609","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61279-9"},{"key":"bibr2-2329048X17725609","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2013.08.001"},{"key":"bibr3-2329048X17725609","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebcr.2013.06.004"},{"key":"bibr4-2329048X17725609","doi-asserted-by":"publisher","DOI":"10.1177\/0883073815600871"},{"key":"bibr5-2329048X17725609","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2013.08.002"},{"key":"bibr6-2329048X17725609","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61134-9"},{"key":"bibr7-2329048X17725609","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61767-X"},{"key":"bibr8-2329048X17725609","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23960"},{"key":"bibr9-2329048X17725609","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5001853"},{"key":"bibr10-2329048X17725609","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2016.0100"},{"key":"bibr11-2329048X17725609","doi-asserted-by":"publisher","DOI":"10.1186\/1824-7288-39-57"},{"key":"bibr12-2329048X17725609","doi-asserted-by":"publisher","DOI":"10.4137\/CMPed.S8304"},{"key":"bibr13-2329048X17725609","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003400"},{"key":"bibr14-2329048X17725609","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003077"}],"container-title":["Child Neurology Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2329048X17725609","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2329048X17725609","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2329048X17725609","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:57:44Z","timestamp":1777391864000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2329048X17725609"}},"subtitle":["A Case Report"],"short-title":[],"issued":{"date-parts":[[2017,1,1]]},"references-count":14,"alternative-id":["10.1177\/2329048X17725609"],"URL":"https:\/\/doi.org\/10.1177\/2329048x17725609","relation":{},"ISSN":["2329-048X","2329-048X"],"issn-type":[{"value":"2329-048X","type":"print"},{"value":"2329-048X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,1]]},"article-number":"2329048X17725609"}}