{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T02:30:29Z","timestamp":1777516229967,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Child Neurology Open"],"published-print":{"date-parts":[[2019,1,1]]},"abstract":"<jats:p>The authors report a case of a germinoma of the brain in the child with symptoms restricted to central nervous system. Ten-year-old girl presented initially with sight deterioration, learning difficulties, abnormal behavior, polydipsia, and polyuria. Brain magnetic resonance examination revealed T2 hyperintensity of the corpus callosum, anterior commissure, and caudate nuclei. Brain biopsy revealed extensive macrophage infiltration. Given these results and positive antinuclear antibodies in the blood, immunosuppressive and immunomodulatory treatment was implemented but it was not effective. The patient developed progressive quadriparesis, sleep disturbances, and dementia. Second brain biopsy was performed and it revealed germinoma cells. Chemotherapy was administered, but the girl died due to disseminated intravascular coagulation syndrome. The reported case shows an unusual coexistence of germinoma with prominent inflammation in the brain and highlights the importance of brain biopsy in such complex cases.<\/jats:p>","DOI":"10.1177\/2329048x19848181","type":"journal-article","created":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T23:57:41Z","timestamp":1558396661000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Germinoma Mimicking Brain Inflammation: A Case Report"],"prefix":"10.1177","volume":"6","author":[{"given":"Katarzyna","family":"Pierzchlewicz","sequence":"first","affiliation":[{"name":"Department of Neurology and Epileptology, Children\u2019s Memorial Health Institute, Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u0142gorzata","family":"Bilska","sequence":"additional","affiliation":[{"name":"Department of Neurology and Epileptology, Children\u2019s Memorial Health Institute, Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"El\u017cbieta","family":"Jurkiewicz","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, Children\u2019s Memorial Health Institute, Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dariusz","family":"Chmielewski","sequence":"additional","affiliation":[{"name":"Department of Neurology and Epileptology, Children\u2019s Memorial Health Institute, Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"El\u017cbieta","family":"Moszczy\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Children\u2019s Memorial Health Institute, Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawe\u0142","family":"Daszkiewicz","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Children\u2019s Memorial Health Institute, Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maciej","family":"Cio\u0142kowski","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Children\u2019s Memorial Health Institute, Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wies\u0142awa","family":"Grajkowska","sequence":"additional","affiliation":[{"name":"Department of Pathology, Children\u2019s Memorial Health Institute, Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Kotulska","sequence":"additional","affiliation":[{"name":"Department of Neurology and Epileptology, Children\u2019s Memorial Health Institute, Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,5,20]]},"reference":[{"key":"bibr1-2329048X19848181","doi-asserted-by":"publisher","DOI":"10.3340\/jkns.2015.57.5.315"},{"key":"bibr2-2329048X19848181","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-014-1247-5"},{"key":"bibr3-2329048X19848181","doi-asserted-by":"publisher","DOI":"10.4103\/0028-3886.117597"},{"key":"bibr4-2329048X19848181","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-015-1809-y"},{"key":"bibr5-2329048X19848181","doi-asserted-by":"publisher","DOI":"10.1002\/path.4098"},{"issue":"1","key":"bibr6-2329048X19848181","doi-asserted-by":"crossref","first-page":"38","DOI":"10.4103\/1817-1745.154330","volume":"10","author":"Gupta R","year":"2015","journal-title":"J Pediatr Neurosci"},{"issue":"10","key":"bibr7-2329048X19848181","first-page":"386","volume":"65","author":"van Battum P","year":"2007","journal-title":"Neth J Med"},{"key":"bibr8-2329048X19848181","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2008-0037"},{"key":"bibr9-2329048X19848181","unstructured":"National Cancer Institute. PDQ\u00ae Childhood Central Nervous System Germ Cell Tumors Treatment. Bethesda, MD: National Cancer Institute. Date last modified; 2015. http:\/\/www.cancer.gov\/types\/brain\/hp\/child-cns-germ-cell-treatment-pdq. Accessed October 22, 2015."},{"key":"bibr10-2329048X19848181","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-011-0673-7"},{"key":"bibr11-2329048X19848181","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.64.5.670"},{"key":"bibr12-2329048X19848181","doi-asserted-by":"publisher","DOI":"10.1080\/08998280.2015.11929183"},{"key":"bibr13-2329048X19848181","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2014.11.013"},{"key":"bibr14-2329048X19848181","first-page":"936937","volume":"2014","author":"Loto MG","year":"2014","journal-title":"Case Rep Endocrinol"}],"container-title":["Child Neurology Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2329048X19848181","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2329048X19848181","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2329048X19848181","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:57:56Z","timestamp":1777391876000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2329048X19848181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,1]]},"references-count":14,"alternative-id":["10.1177\/2329048X19848181"],"URL":"https:\/\/doi.org\/10.1177\/2329048x19848181","relation":{},"ISSN":["2329-048X","2329-048X"],"issn-type":[{"value":"2329-048X","type":"print"},{"value":"2329-048X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,1]]},"article-number":"2329048X19848181"}}