{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T22:30:04Z","timestamp":1783117804741,"version":"3.54.6"},"reference-count":28,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007299","name":"Plagio Prevention LLC","doi-asserted-by":"publisher","award":["n\/a"],"award-info":[{"award-number":["n\/a"]}],"id":[{"id":"10.13039\/100007299","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Child Neurology Open"],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This case report aims to assess a potential association between cranial asymmetry, brain deformation, and associated developmental delay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design:<\/jats:title>\n                    <jats:p>Two infants born at \u226537 weeks pursuing cranial orthotic treatment for severe Deformational Plagiocephaly (DP) (cranial vault asymmetry index &gt;8.75%) underwent developmental assessment using Mullen Scales of Early Learning (MSEL) and non-sedated brain structural and diffusion magnetic resonance imaging (MRI) prior to and following cranial orthotic treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In both infants with DP, tractography results revealed alterations in the white matter pathways of the brain. Both infants also had low to low\/normal visual receptivity and fine motor skills. After cranial orthotic treatment, cranial asymmetry improved but did not completely resolve, tractography demonstrated a change toward normalized white matter pathways, and visual receptivity and fine motor skills improved.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>These preliminary findings suggest a potential link between DP, altered brain structures, and developmental assessment. Further investigation with a larger sample is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2329048x20949769","type":"journal-article","created":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T07:52:27Z","timestamp":1597823547000},"page":"2329048X2094976","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Brain Characteristics Noted Prior to and Following Cranial Orthotic Treatment"],"prefix":"10.1177","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7362-3394","authenticated-orcid":false,"given":"Michele","family":"DeGrazia","sequence":"first","affiliation":[{"name":"Cardiovascular and Critical Care, Boston Children\u2019s Hospital, Boston, MA, USA"},{"name":"Department of Pediatrics, Harvard Medical School, Boston, MA, USA"},{"name":"Division of Newborn Medicine, Boston Children\u2019s Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banu","family":"Ahtam","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Harvard Medical School, Boston, MA, USA"},{"name":"Division of Newborn Medicine, Boston Children\u2019s Hospital, Boston, MA, USA"},{"name":"Fetal-Neonatal Neuroimaging and Developmental Science Center, Boston Children\u2019s Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn R.","family":"Rogers-Vizena","sequence":"additional","affiliation":[{"name":"Department of Plastic and Oral Surgery, Boston Children\u2019s Hospital, Boston, MA, USA"},{"name":"Department of Surgery, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Proctor","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Boston Children\u2019s Hospital, Boston, MA, USA"},{"name":"Department of Neurosurgery, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney","family":"Porter","sequence":"additional","affiliation":[{"name":"Cardiovascular and Critical Care, Boston Children\u2019s Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rutvi","family":"Vyas","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Harvard Medical School, Boston, MA, USA"},{"name":"Division of Newborn Medicine, Boston Children\u2019s Hospital, Boston, MA, USA"},{"name":"Fetal-Neonatal Neuroimaging and Developmental Science Center, Boston Children\u2019s Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia T.","family":"Laurentys","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Harvard Medical School, Boston, MA, USA"},{"name":"Division of Newborn Medicine, Boston Children\u2019s Hospital, Boston, MA, USA"},{"name":"Fetal-Neonatal 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