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The diagnostic approach of ANEC consists of clinical manifestation, laboratory examination, cerebrospinal fluid (CSF) analysis, and neuroimaging interpretation. The patient had high liver enzyme, normal CSF analysis with appearances of edema, hemorrhage and necrosis in serial brain magnetic resonance imaging (MRI).<\/jats:p>","DOI":"10.1177\/2329048x221095699","type":"journal-article","created":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T01:25:26Z","timestamp":1651627526000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Difficulties in Diagnosis Acute Necrotizing Encephalopathy of Childhood: A Case Report"],"prefix":"10.1177","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6968-9780","authenticated-orcid":false,"given":"Setyo","family":"Handryastuti","sequence":"first","affiliation":[{"name":"Department of Child Health, Dr.Cipto Mangunkusumo Tertiary General Hospital, Faculty of Medicine Universitas Indonesia Jakarta, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sisca","family":"Silvana","sequence":"additional","affiliation":[{"name":"HKBP Nommensen University, Medan, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9046-6303","authenticated-orcid":false,"given":"Reyhan Eddy","family":"Yunus","sequence":"additional","affiliation":[{"name":"Department of Radiology, Dr.Cipto Mangunkusumo Tertiary General Hospital, Faculty of Medicine Universitas Indonesia Jakarta, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iqbal","family":"Taufiqqurrachman","sequence":"additional","affiliation":[{"name":"Department of Child Health, Dr.Cipto Mangunkusumo Tertiary General Hospital, Faculty of Medicine Universitas Indonesia Jakarta, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Achmad","family":"Rafli","sequence":"additional","affiliation":[{"name":"Department of Child Health, Dr.Cipto Mangunkusumo Tertiary General Hospital, Faculty of Medicine Universitas Indonesia Jakarta, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,5,3]]},"reference":[{"issue":"1","key":"bibr1-2329048X221095699","first-page":"75","volume":"11","author":"Rad H","year":"2017","journal-title":"Iran J Child Neurol"},{"issue":"9","key":"bibr2-2329048X221095699","first-page":"1919","volume":"27","author":"Wong AM","year":"2006","journal-title":"Am J Neuroradiol"},{"issue":"1","key":"bibr3-2329048X221095699","first-page":"133","volume":"14","author":"Hosseini SA","year":"2020","journal-title":"Iran J Child Neurol"},{"key":"bibr4-2329048X221095699","first-page":"1","volume":"2015","author":"Wu X","year":"2015","journal-title":"Mediators Inflamm"},{"key":"bibr5-2329048X221095699","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2020.00526"},{"key":"bibr6-2329048X221095699","doi-asserted-by":"publisher","DOI":"10.15761\/CMI.1000204"},{"issue":"2","key":"bibr7-2329048X221095699","first-page":"51","volume":"7","author":"Salehiomran M","year":"2013","journal-title":"Iran J Child Neurol"}],"container-title":["Child Neurology Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2329048X221095699","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2329048X221095699","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2329048X221095699","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:58:17Z","timestamp":1777391897000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2329048X221095699"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":7,"alternative-id":["10.1177\/2329048X221095699"],"URL":"https:\/\/doi.org\/10.1177\/2329048x221095699","relation":{},"ISSN":["2329-048X","2329-048X"],"issn-type":[{"value":"2329-048X","type":"print"},{"value":"2329-048X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"article-number":"2329048X221095699"}}