{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T02:28:07Z","timestamp":1777516087647,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Child Neurology Open"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>Anti-SRY-related HMG-box gene 1 (SOX1) antibodies were initially described in adults with paraneoplastic neurological disorders, where they are considered high-risk onconeural autoantibodies. Only two pediatric cases of anti-SOX1 antibodies have been reported: a 17-year-old adolescent presenting with paraneoplastic limbic encephalitis due to Hodgkin lymphoma and a 12-year-old girl presenting with non-paraneoplastic encephalitis. We present a unique case of anti-SOX1 antibodies in a 3-year-old girl, post-varicella infection. Initially, she presented with ataxia and dysmetria, with subsequent reports from parents of urinary incontinence and significant behavior changes. Additionally, reflexes in the lower limbs were absent. Anti-SOX1 antibodies tested positive in both serum and cerebrospinal fluid. Oncological screening at presentation and a seven-month follow-up showed no malignancies. The patient exhibited favorable clinical progress without requiring treatment. At the seven-month follow-up, serum antibodies tested negative. This case report broadens the known clinical spectrum, being the first description of post-varicella anti-SOX1 antibodies.<\/jats:p>","DOI":"10.1177\/2329048x231200613","type":"journal-article","created":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T01:31:03Z","timestamp":1695346263000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Anti-SOX1 Antibodies in a 3-Year-old Girl, Post-Varicella"],"prefix":"10.1177","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-2638-8186","authenticated-orcid":false,"given":"Aline","family":"Wijnand","sequence":"first","affiliation":[{"name":"Department of Child and Adolescent Psychiatry, Ghent University Hospital, Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helene","family":"Verhelst","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Neurology, Ghent University Hospital, Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,9,21]]},"reference":[{"key":"bibr1-2329048X231200613","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000281663.81079.24"},{"key":"bibr2-2329048X231200613","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2005.03.020"},{"key":"bibr3-2329048X231200613","doi-asserted-by":"publisher","DOI":"10.1038\/nn1131"},{"key":"bibr4-2329048X231200613","doi-asserted-by":"publisher","DOI":"10.1007\/s003359900597"},{"key":"bibr5-2329048X231200613","doi-asserted-by":"publisher","DOI":"10.1242\/dev.125.10.1967"},{"key":"bibr6-2329048X231200613","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2020.16.4.530"},{"key":"bibr7-2329048X231200613","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-022-11523-y"},{"key":"bibr8-2329048X231200613","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2016.09.002"},{"key":"bibr9-2329048X231200613","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2010.07.005"},{"key":"bibr10-2329048X231200613","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2017.03.005"},{"key":"bibr11-2329048X231200613","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6666117"},{"key":"bibr12-2329048X231200613","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000001014"},{"key":"bibr13-2329048X231200613","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2004.040378"},{"key":"bibr14-2329048X231200613","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e31821f0ec4"},{"key":"bibr15-2329048X231200613","doi-asserted-by":"publisher","DOI":"10.1017\/s0317167100001074"},{"key":"bibr16-2329048X231200613","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-3-11"},{"key":"bibr17-2329048X231200613","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000178802.38268.1e"},{"key":"bibr18-2329048X231200613","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2006.09.004"},{"key":"bibr19-2329048X231200613","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70310-1"}],"container-title":["Child Neurology Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2329048X231200613","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2329048X231200613","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2329048X231200613","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:57:25Z","timestamp":1777391845000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2329048X231200613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":19,"alternative-id":["10.1177\/2329048X231200613"],"URL":"https:\/\/doi.org\/10.1177\/2329048x231200613","relation":{},"ISSN":["2329-048X","2329-048X"],"issn-type":[{"value":"2329-048X","type":"print"},{"value":"2329-048X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]},"article-number":"2329048X231200613"}}