{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:57:04Z","timestamp":1777881424373,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Trends in Hearing"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>In the face of finite resources, allocations of research and health-care funding are dependent upon high-quality evidence. Historically, tinnitus has been the poor cousin of hearing science, with low-quality clinical research providing unreliable estimates of effect and with devices marketed for tinnitus without strong evidence for those product claims. However, the tinnitus field is changing. Key opinion leaders have recently made calls to the field to improve the design, implementation, and reporting of clinical trials, and there is growing intersectoral collaboration. The Tonndorf Lecture presented at the 1st World Tinnitus Congress and the 12th International Tinnitus Seminar in Warsaw, Poland, provided an opportunity to reflect on the present and future progress of tinnitus research and treatment and what is needed for the field to achieve success. The content of that lecture is summarized in this article. The main debate concerns the selection and reporting of outcomes in clinical trials of tinnitus. Comprehensive reviews of the literature confirm the diversity of the personal impact of tinnitus and illustrate a lack of consensus in what aspects of tinnitus should be assessed and reported in a clinical trial. An innovative project is described which engages the global tinnitus community (patients and professionals alike) in working together. This project seeks to improve future tinnitus research by creating an evidence-based consensus about minimum reporting standards for outcomes in clinical trials of a tinnitus intervention. The output will be a core set of important and critical outcomes to be measured and reported in all clinical trials.<\/jats:p>","DOI":"10.1177\/2331216517736689","type":"journal-article","created":{"date-parts":[[2017,10,27]],"date-time":"2017-10-27T05:37:29Z","timestamp":1509082649000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Designing Clinical Trials for Assessing the Effectiveness of Interventions for Tinnitus"],"prefix":"10.1177","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3804-1452","authenticated-orcid":false,"given":"Deborah A.","family":"Hall","sequence":"first","affiliation":[{"name":"Otology and Hearing Group, Division of Clinical Neuroscience, School of Medicine, University of Nottingham, UK"},{"name":"Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, UK"},{"name":"Nottingham University Hospitals NHS Trust, Queen\u2019s Medical Centre, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,10,27]]},"reference":[{"key":"bibr1-2331216517736689","unstructured":"AAO-HNS. (2017).\n                      Research needs: Tinnitus\n                      . Retrieved from http:\/\/www.entnet.org\/node\/1825."},{"key":"bibr2-2331216517736689","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-016-0188-6"},{"key":"bibr3-2331216517736689","unstructured":"CONSORT. (2017).\n                      The CONSORT statement\n                      . Retrieved from http:\/\/www.consort-statement.org\/."},{"key":"bibr4-2331216517736689","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7406.65"},{"key":"bibr5-2331216517736689","first-page":"13","volume-title":"Tinnitus: Causes, treatment and short & long-term health effects","author":"Fackrell K.","year":"2014"},{"key":"bibr116-2331216517736689","doi-asserted-by":"crossref","unstructured":"Fackrell, K., Hall, D.A., Barry, J.G. & Hoare, D.J. (2016). Psychometric properties of the Tinnitus Functional Index (TFI): Assessment in a UK research volunteer population.\n                      Hearing Research\n                      ,\n                      335\n                      , 220\u2013235. DOI:10.1016\/j.heares.2015.09.009.","DOI":"10.1016\/j.heares.2015.09.009"},{"issue":"1","key":"bibr6-2331216517736689","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1186\/s13063-017-2123-0","volume":"18","author":"Fackrell K.","year":"2017","journal-title":"Trials"},{"key":"bibr7-2331216517736689","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2017.00206"},{"key":"bibr8-2331216517736689","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.09.012"},{"key":"bibr9-2331216517736689","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-009171"},{"key":"bibr10-2331216517736689","doi-asserted-by":"crossref","unstructured":"Hall, D. A., Fackrell, K., Li, A. B., Thavayogan, R., Smith, S., Kennedy, V.\u2026Haider H. F. (2017). A narrative synthesis of research evidence for tinnitus-related complaints as reported by patients and their significant others. Manuscript submitted for publication.","DOI":"10.1186\/s12955-018-0888-9"},{"key":"bibr11-2331216517736689","first-page":"19","volume":"24","author":"Hall D. A.","year":"2015","journal-title":"Trends in Hearing"},{"key":"bibr12-2331216517736689","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-016-1399-9"},{"key":"bibr13-2331216517736689","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6963-11-302"},{"key":"bibr14-2331216517736689","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-009091"},{"key":"bibr15-2331216517736689","first-page":"CD003852","volume":"3","author":"Hilton M. P.","year":"2013","journal-title":"The Cochrane Database of Systematic Reviews"},{"key":"bibr16-2331216517736689","first-page":"CD010151","volume":"1","author":"Hoare D. J.","year":"2014","journal-title":"The Cochrane Database of Systematic Reviews"},{"key":"bibr17-2331216517736689","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-14-207"},{"key":"bibr18-2331216517736689","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-141-10-200411160-00009"},{"key":"bibr19-2331216517736689","unstructured":"Iqbal, S. & Pipon-Young, L. (2009). The Delphi method.\n                      The Psychologist\n                      ,\n                      22\n                      , 598\u2013601. Retrieved from https:\/\/thepsychologist.bps.org.uk\/volume-22\/edition-7\/delphi-method."},{"key":"bibr20-2331216517736689","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2010.03.026"},{"key":"bibr21-2331216517736689","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(07)66050-6"},{"key":"bibr22-2331216517736689","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2017.00042"},{"key":"bibr23-2331216517736689","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c869"},{"key":"bibr24-2331216517736689","doi-asserted-by":"publisher","DOI":"10.1097\/01.HJ.0000293150.63349.c7"},{"key":"bibr25-2331216517736689","first-page":"CD009832","volume":"11","author":"Person O. C.","year":"2016","journal-title":"The Cochrane Database of Systematic Reviews"},{"key":"bibr26-2331216517736689","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-016-1555-2"},{"key":"bibr27-2331216517736689","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-016-0558-7"},{"key":"bibr28-2331216517736689","unstructured":"TINNET. (2016). Recommendations for designing and reporting trials of clinical efficacy. Version number: 1.1. Retrieved from http:\/\/tinnet.tinnitusresearch.net\/images\/pdf\/WG5\/TINNET-WG5-recommendations_v1.1.pdf."},{"key":"bibr29-2331216517736689","unstructured":"TINNET. (2017). Description of WG 5: Development of standards for outcome measurements in clinical trials and central data collection. Retrieved from http:\/\/tinnet.tinnitusresearch.net\/index.php\/2015-10-29-10-22-16\/wg-5-outcome-measurement."},{"key":"bibr30-2331216517736689","doi-asserted-by":"publisher","DOI":"10.1177\/0194599814545325"},{"key":"bibr31-2331216517736689","unstructured":"Tyler, R. (1999). The use of science to find successful tinnitus treatments. In J. Hazell (Ed.),\n                      Proceedings of the sixth international tinnitus seminar\n                      , Cambridge, England. Retrieved from http:\/\/www.tinnitus.org\/Proceedings%20ITS99.pdf."},{"key":"bibr32-2331216517736689","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-13-132"}],"container-title":["Trends in Hearing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2331216517736689","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2331216517736689","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2331216517736689","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:42:27Z","timestamp":1777596147000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2331216517736689"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":33,"alternative-id":["10.1177\/2331216517736689"],"URL":"https:\/\/doi.org\/10.1177\/2331216517736689","relation":{},"ISSN":["2331-2165","2331-2165"],"issn-type":[{"value":"2331-2165","type":"print"},{"value":"2331-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1]]},"article-number":"2331216517736689"}}