{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T16:28:43Z","timestamp":1793982523990,"version":"4.8.0"},"reference-count":39,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["R00DC014288"],"award-info":[{"award-number":["R00DC014288"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Trends in Hearing"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>The frequency-specific tone-evoked auditory brainstem response (ABR) is an indispensable tool in both the audiology clinic and research laboratory. Most frequently, the toneburst ABR is used to estimate hearing thresholds in infants, toddlers, and other patients for whom behavioral testing is not feasible. Therefore, results of the ABR exam form the basis for decisions regarding interventions and hearing habilitation with implications extending far into the child\u2019s future. Currently, responses are elicited by periodic sequences of toneburst stimuli presented serially to one ear at a time, which take a long time to measure multiple frequencies and intensities, and provide incomplete information if the infant wakes up early. Here, we describe a new method, the parallel ABR (pABR), which uses randomly timed toneburst stimuli to simultaneously acquire ABR waveforms to five frequencies in both ears. Here, we describe the pABR and quantify its effectiveness in addressing the greatest drawback of current methods: test duration. We show that in adults with normal hearing the pABR yields high-quality waveforms over a range of intensities, with similar morphology to the standard ABR in a fraction of the recording time. Furthermore, longer latencies and smaller amplitudes for low frequencies at a high intensity evoked by the pABR versus serial ABR suggest that responses may have better place specificity due to the masking provided by the other simultaneous toneburst sequences. Thus, the pABR has substantial potential for facilitating faster accumulation of more diagnostic information that is important for timely identification and treatment of hearing loss.<\/jats:p>","DOI":"10.1177\/2331216519871395","type":"journal-article","created":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T05:23:32Z","timestamp":1568352212000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":54,"title":["The Parallel Auditory Brainstem Response"],"prefix":"10.1177","volume":"23","author":[{"given":"Melissa J.","family":"Polonenko","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, University of Rochester, NY, USA"},{"name":"Department of Neuroscience, Del Monte Institute for Neuroscience, University of Rochester, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2668-0238","authenticated-orcid":false,"given":"Ross K.","family":"Maddox","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of Rochester, NY, USA"},{"name":"Department of Neuroscience, Del Monte Institute for Neuroscience, University of Rochester, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,9,13]]},"reference":[{"key":"bibr1-2331216519871395","unstructured":"American Academy of Audiology. (2012).\n                      Audiologic guidelines for the assessment of hearing in infants and young children\n                      . Reston (VA, 2-52) Retrieved from https:\/\/www.asha.org\/articlesummary.aspx?id=8589961387."},{"key":"bibr2-2331216519871395","unstructured":"BC Early Hearing Program. (2012).\n                      Audiology assessment protocol\n                      . Retrieved from http:\/\/www.phsa.ca\/Documents\/bcehpaudiologyassessmentprotocol.pdf."},{"key":"bibr3-2331216519871395","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e318242b2cd"},{"key":"bibr4-2331216519871395","volume-title":"Auditory evoked potentials: Basic principles and clinical application","author":"Burkard R. F.","year":"2006","edition":"1"},{"key":"bibr5-2331216519871395","doi-asserted-by":"publisher","DOI":"10.1179\/1467010014Z.000000000168"},{"key":"bibr6-2331216519871395","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aet173"},{"key":"bibr7-2331216519871395","doi-asserted-by":"publisher","DOI":"10.1080\/14670100.2016.1265055"},{"key":"bibr8-2331216519871395","doi-asserted-by":"publisher","DOI":"10.3109\/01050398509045928"},{"key":"bibr9-2331216519871395","doi-asserted-by":"publisher","DOI":"10.3109\/00206098209072742"},{"key":"bibr10-2331216519871395","doi-asserted-by":"publisher","DOI":"10.3109\/14992027.2011.601469"},{"key":"bibr11-2331216519871395","doi-asserted-by":"publisher","DOI":"10.1097\/01.aud.0000194511.14740.9c"},{"key":"bibr12-2331216519871395","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2013.00267"},{"key":"bibr13-2331216519871395","doi-asserted-by":"publisher","DOI":"10.1002\/dev.20052"},{"key":"bibr14-2331216519871395","volume-title":"Clinical applications of the auditory brainstem response","author":"Hood L. J.","year":"1998","edition":"1"},{"key":"bibr16-2331216519871395","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-03-00876.2003"},{"key":"bibr17-2331216519871395","doi-asserted-by":"crossref","unstructured":"Joint Committee on Infant Hearing. (2007). Year 2007 position statement: Principles and guidelines for early hearing detection and intervention. Advance online publication. doi:10.1044\/policy.PS2007-00281.","DOI":"10.1044\/policy.PS2007-00281"},{"key":"bibr18-2331216519871395","doi-asserted-by":"publisher","DOI":"10.3766\/jaaa.23.3.3"},{"key":"bibr19-2331216519871395","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0162726"},{"key":"bibr20-2331216519871395","doi-asserted-by":"publisher","DOI":"10.1159\/000088852"},{"key":"bibr21-2331216519871395","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2012.02.051"},{"key":"bibr22-2331216519871395","doi-asserted-by":"publisher","DOI":"10.1542\/peds.106.3.e43"},{"key":"bibr23-2331216519871395","unstructured":"NHS Newborn Hearing Screening Programme. (2013).\n                      Guidelines for the early audiological assessment and management of babies referred from the Newborn Hearing Screening Programme\n                      . Retrieved from https:\/\/www.thebsa.org.uk\/resources\/guidelines-early-audiologicalassessment-management-babies-referred-newborn-hearingscreening-programme."},{"key":"bibr106-2331216519871395","unstructured":"Ontario Ministry of Children and Youth Services. (2016). Ontario Infant Hearing Program: Protocol for auditory brainstem response-based audiological assessment (ABRA). Toronto, ON (Canada): Ontario Ministry of Children and Youth Services, (Version 2016.02). Retrieved from https:\/\/www.mountsinai.on.ca\/care\/infant-hearingprogram\/health-professionals."},{"key":"bibr24-2331216519871395","doi-asserted-by":"publisher","DOI":"10.1121\/1.2133682"},{"key":"bibr25-2331216519871395","doi-asserted-by":"publisher","DOI":"10.1097\/01.AUD.0000069226.22983.80"},{"key":"bibr26-2331216519871395","doi-asserted-by":"publisher","DOI":"10.1590\/S1516-18462013000400008"},{"key":"bibr27-2331216519871395","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2001.81.3.1305"},{"key":"bibr28-2331216519871395","doi-asserted-by":"publisher","DOI":"10.1097\/AUD.0000000000000580"},{"key":"bibr29-2331216519871395","unstructured":"Stapells, D. R. (2011).\n                      Frequency-specific ABR and ASSR threshold assessment in young infants\n                      . Retrieved from http:\/\/www.phonak.com\/content\/dam\/phonak\/gc_hq\/b2b\/en\/events\/2010\/Proceedings\/Pho_Chap_04_Stapells_final.pdf."},{"key":"bibr30-2331216519871395","doi-asserted-by":"publisher","DOI":"10.1159\/000259252"},{"key":"bibr31-2331216519871395","doi-asserted-by":"publisher","DOI":"10.1542\/peds.103.2.527"},{"key":"bibr32-2331216519871395","unstructured":"U.S. Food and Drug Administration. (2017, April 27). Drug safety and availability\u2014FDA drug safety communication: FDA approves label changes for use of general anesthetic and sedation drugs in young children [WebContent]. Retrieved from https:\/\/www.fda.gov\/Drugs\/DrugSafety\/ucm554634.htm."},{"key":"bibr33-2331216519871395","doi-asserted-by":"publisher","DOI":"10.1121\/1.4764511"},{"key":"bibr34-2331216519871395","doi-asserted-by":"publisher","DOI":"10.1121\/1.4900832"},{"key":"bibr35-2331216519871395","doi-asserted-by":"publisher","DOI":"10.1002\/mrdd.10070"},{"key":"bibr36-2331216519871395","doi-asserted-by":"publisher","DOI":"10.1097\/ANA.0000000000000118"},{"key":"bibr37-2331216519871395","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2560\/10\/2\/026023"},{"key":"bibr38-2331216519871395","doi-asserted-by":"publisher","DOI":"10.1097\/01.anes.0000344728.34332.5d"},{"key":"bibr39-2331216519871395","doi-asserted-by":"publisher","DOI":"10.1542\/peds.102.5.1161"}],"container-title":["Trends in Hearing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2331216519871395","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2331216519871395","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2331216519871395","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:44:46Z","timestamp":1777596286000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2331216519871395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":39,"alternative-id":["10.1177\/2331216519871395"],"URL":"https:\/\/doi.org\/10.1177\/2331216519871395","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/648659","asserted-by":"object"}]},"ISSN":["2331-2165","2331-2165"],"issn-type":[{"value":"2331-2165","type":"print"},{"value":"2331-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1]]},"article-number":"2331216519871395"}}