{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T10:58:43Z","timestamp":1788778723376,"version":"build-2803163510"},"reference-count":45,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/L003589\/1"],"award-info":[{"award-number":["MR\/L003589\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Trends in Hearing"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>Although there is strong histological evidence for age-related synaptopathy in humans, evidence for the existence of noise-induced cochlear synaptopathy in humans is inconclusive. Here, we sought to evaluate the relative contributions of age and noise exposure to cochlear synaptopathy using a series of electrophysiological and behavioral measures. We extended an existing cohort by including 33 adults in the age range 37 to 60, resulting in a total of 156 participants, with the additional older participants resulting in a weakening of the correlation between lifetime noise exposure and age. We used six independent regression models (corrected for multiple comparisons), in which age, lifetime noise exposure, and high-frequency audiometric thresholds were used to predict measures of synaptopathy, with a focus on differential measures. The models for auditory brainstem responses, envelope-following responses, interaural phase discrimination, and the co-ordinate response measure of speech perception were not statistically significant. However, both age and noise exposure were significant predictors of performance on the digit triplet test of speech perception in noise, with greater noise exposure (unexpectedly) predicting better performance in the 80\u2009dB sound pressure level (SPL) condition and greater age predicting better performance in the 40\u2009dB SPL condition. Amplitude modulation detection thresholds were also significantly predicted by age, with older listeners performing better than younger listeners at 80\u2009dB SPL. Overall, the results are inconsistent with the predicted effects of synaptopathy.<\/jats:p>","DOI":"10.1177\/2331216519877301","type":"journal-article","created":{"date-parts":[[2019,9,27]],"date-time":"2019-09-27T03:08:42Z","timestamp":1569553722000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":49,"title":["Effects of Age and Noise Exposure on Proxy Measures of Cochlear Synaptopathy"],"prefix":"10.1177","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7255-6708","authenticated-orcid":false,"given":"Garreth","family":"Prendergast","sequence":"first","affiliation":[{"name":"Manchester Centre for Audiology and Deafness, The University of Manchester, Manchester Academic Health Science Centre, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3635-863X","authenticated-orcid":false,"given":"Samuel","family":"Couth","sequence":"additional","affiliation":[{"name":"Manchester Centre for Audiology and Deafness, The University of Manchester, Manchester Academic Health Science Centre, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca E.","family":"Millman","sequence":"additional","affiliation":[{"name":"Manchester Centre for Audiology and Deafness, The University of Manchester, Manchester Academic Health Science Centre, UK"},{"name":"NIHR Manchester Biomedical Research Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4981-6663","authenticated-orcid":false,"given":"Hannah","family":"Guest","sequence":"additional","affiliation":[{"name":"Manchester Centre for Audiology and Deafness, The University of Manchester, Manchester Academic Health Science Centre, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Kluk","sequence":"additional","affiliation":[{"name":"Manchester Centre for Audiology and Deafness, The University of Manchester, Manchester Academic Health Science Centre, UK"},{"name":"NIHR Manchester Biomedical Research Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6543-9098","authenticated-orcid":false,"given":"Kevin J.","family":"Munro","sequence":"additional","affiliation":[{"name":"Manchester Centre for Audiology and Deafness, The University of Manchester, Manchester Academic Health Science Centre, UK"},{"name":"NIHR Manchester Biomedical Research Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Plack","sequence":"additional","affiliation":[{"name":"Manchester Centre for Audiology and Deafness, The University of Manchester, Manchester Academic Health Science Centre, UK"},{"name":"NIHR Manchester Biomedical Research Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK"},{"name":"Department of Psychology, Lancaster University, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,9,27]]},"reference":[{"key":"bibr1-2331216519877301","doi-asserted-by":"publisher","DOI":"10.1121\/1.1497620"},{"key":"bibr2-2331216519877301","doi-asserted-by":"publisher","DOI":"10.1121\/1.428288"},{"key":"bibr3-2331216519877301","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00738.2013"},{"key":"bibr4-2331216519877301","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2019.02.016"},{"key":"bibr5-2331216519877301","doi-asserted-by":"publisher","DOI":"10.1097\/AUD.0000000000000370"},{"key":"bibr6-2331216519877301","unstructured":"British Society of Audiology. (2011).\n                      Pure-tone air-conduction and bone-conduction threshold audiometry with and without masking. Recommended\n                      procedure (pp. 1\u201332). Reading, England: Author."},{"key":"bibr50-2331216519877301","doi-asserted-by":"crossref","unstructured":"Carney, L. H. (2018). Supra-threshold hearing and fluctuation profiles: Implications for sensorineural and hidden hearing loss.\n                      Journal of the Accociation for Research into Otolaryngology\n                      ,\n                      19\n                      , 331\u2013352. doi: 10.1007\/s10162-018-0669-5.","DOI":"10.1007\/s10162-018-0669-5"},{"key":"bibr7-2331216519877301","doi-asserted-by":"publisher","DOI":"10.1080\/14992027.2016.1255359"},{"key":"bibr8-2331216519877301","doi-asserted-by":"publisher","DOI":"10.1080\/14992027.2019.1600203"},{"key":"bibr9-2331216519877301","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1606325"},{"key":"bibr10-2331216519877301","first-page":"347","volume":"6","author":"F\u00fcllgrabe C.","year":"2015","journal-title":"Frontiers in Aging Neuroscience"},{"key":"bibr11-2331216519877301","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00164.2013"},{"key":"bibr12-2331216519877301","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2017.00465"},{"key":"bibr13-2331216519877301","doi-asserted-by":"publisher","DOI":"10.1177\/2331216517737417"},{"key":"bibr14-2331216519877301","doi-asserted-by":"publisher","DOI":"10.1177\/2331216518803213"},{"key":"bibr15-2331216519877301","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2016.12.002"},{"key":"bibr16-2331216519877301","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2018.03.008"},{"key":"bibr17-2331216519877301","doi-asserted-by":"publisher","DOI":"10.1097\/00003446-199306000-00002"},{"key":"bibr18-2331216519877301","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2016.12.010"},{"key":"bibr19-2331216519877301","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1980.00790310011003"},{"key":"bibr20-2331216519877301","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2019.01.017"},{"key":"bibr21-2331216519877301","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2845-09.2009"},{"key":"bibr22-2331216519877301","doi-asserted-by":"publisher","DOI":"10.7874\/kja.2013.17.2.45"},{"key":"bibr23-2331216519877301","first-page":"1","volume":"18","author":"Le Prell C. G.","year":"2019","journal-title":"International Journal of Audiology"},{"key":"bibr24-2331216519877301","doi-asserted-by":"crossref","first-page":"e0162726","DOI":"10.1371\/journal.pone.0162726","volume":"19","author":"Liberman M. C.","year":"2016","journal-title":"PLoS One"},{"key":"bibr45-2331216519877301","doi-asserted-by":"crossref","unstructured":"Makary, C.A., Shin, J., Kujawa, S.G., Liberman, M.C., Merchant, S.N. (2011). Age-related primary cochlear neuronal degeneration in human temporal bones.\n                      Journal of the Association for Research into Otolaryngology\n                      ,\n                      12\n                      , 711\u2013717. doi:10.1007\/s10162-011-0283-2.","DOI":"10.1007\/s10162-011-0283-2"},{"key":"bibr25-2331216519877301","doi-asserted-by":"publisher","DOI":"10.2307\/1267205"},{"key":"bibr46-2331216519877301","doi-asserted-by":"crossref","unstructured":"Parthasarathy, A. & Kujawa, S. G. (2018). Synaptopathy in the aging cochlea: Characterizing early-neural deficits in auditory temporal envelope processing.\n                      Journal of Neuroscience\n                      ,\n                      38\n                      , 7108\u20137119. doi: 10.1523\/JNEUROSCI.3240-17.2018.","DOI":"10.1523\/JNEUROSCI.3240-17.2018"},{"key":"bibr26-2331216519877301","doi-asserted-by":"publisher","DOI":"10.1177\/2331216516657466"},{"key":"bibr27-2331216519877301","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2016.10.028"},{"key":"bibr28-2331216519877301","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2017.10.007"},{"key":"bibr29-2331216519877301","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2018.04.002"},{"key":"bibr31-2331216519877301","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1783-13.2013"},{"key":"bibr32-2331216519877301","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2018.11.008"},{"key":"bibr33-2331216519877301","doi-asserted-by":"publisher","DOI":"10.1080\/14992020400050004"},{"key":"bibr34-2331216519877301","doi-asserted-by":"publisher","DOI":"10.3109\/14992027.2013.865844"},{"key":"bibr35-2331216519877301","doi-asserted-by":"publisher","DOI":"10.1097\/AUD.0000000000000107"},{"key":"bibr36-2331216519877301","doi-asserted-by":"crossref","unstructured":"Stamper, G. C. & Johnson, T. A. (2015b). Letter to the Editor: Examination of potential sex influences in Stamper, G. C. & Johnson, T. A. (2015). Auditory function in normal-hearing, noise-exposed human ears.\n                      Ear and Hearing\n                      ,\n                      36\n                      , 172\u2013184. doi:10.1097\/AUD.0000000000000228.","DOI":"10.1097\/AUD.0000000000000107"},{"key":"bibr37-2331216519877301","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2018.06.003"},{"key":"bibr38-2331216519877301","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2017.07.003"},{"key":"bibr39-2331216519877301","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2017.12.018"},{"key":"bibr40-2331216519877301","doi-asserted-by":"crossref","unstructured":"Verhulst, S., Jagadeesh, A., Mauermann, M. & Ernst, F. (2016). Individual differences in auditory brainstem response wave characteristics: Relations to different aspects of peripheral hearing loss.\n                      Trends in Hearing\n                      ,\n                      20\n                      , doi:10.1177\/2331216516672186.","DOI":"10.1177\/2331216516672186"},{"key":"bibr41-2331216519877301","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2015.04.014"},{"key":"bibr42-2331216519877301","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2018.07.053"},{"key":"bibr43-2331216519877301","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2017.07.006"}],"container-title":["Trends in Hearing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2331216519877301","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2331216519877301","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2331216519877301","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:44:51Z","timestamp":1777596291000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2331216519877301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":45,"alternative-id":["10.1177\/2331216519877301"],"URL":"https:\/\/doi.org\/10.1177\/2331216519877301","relation":{},"ISSN":["2331-2165","2331-2165"],"issn-type":[{"value":"2331-2165","type":"print"},{"value":"2331-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1]]},"article-number":"2331216519877301"}}