{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:56:08Z","timestamp":1790430968610,"version":"4.1.0"},"reference-count":34,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Bernafon AG, Bern, Switzerland"},{"name":"Infrastructure Grant of the University of Bern, Bern, Switzerland"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Trends in Hearing"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Residual inhibition, that is, the temporary suppression of tinnitus loudness after acoustic stimulation, is a frequently observed phenomenon that may have prognostic value for clinical applications. However, it is unclear in which subjects residual inhibition is more likely and how stable the effect of inhibition is over multiple repetitions. The primary aim of this work was to evaluate the effect of hearing loss and tinnitus chronicity on residual inhibition susceptibility. The secondary aim was to investigate the short-term repeatability of residual inhibition. Residual inhibition was assessed in 74 tinnitus subjects with 60-second narrow-band noise stimuli in 10 consecutive trials. The subjects were assigned to groups according to their depth of suppression (substantial residual inhibition vs. comparator group). In addition, a categorization in normal hearing and hearing loss groups, related to the degree of hearing loss at the frequency corresponding to the tinnitus pitch, was made. Logistic regression was used to identify factors associated with susceptibility to residual inhibition. Repeatability of residual inhibition was assessed using mixed-effects ordinal regression including poststimulus time and repetitions as factors. Tinnitus chronicity was not associated with residual inhibition for subjects with hearing loss, while a statistically significant negative association between tinnitus chronicity and residual inhibition susceptibility was observed in normal hearing subjects (odds ratio: 0.63; p\u2009=\u2009.0076). Moreover, repeated states of suppression can be stably induced, reinforcing the use of residual inhibition for within-subject comparison studies.<\/jats:p>","DOI":"10.1177\/2331216520986303","type":"journal-article","created":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T21:37:47Z","timestamp":1614893867000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Susceptibility to Residual Inhibition Is Associated With Hearing Loss and Tinnitus Chronicity"],"prefix":"10.1177","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1392-2357","authenticated-orcid":false,"given":"S.","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Bern University Hospital, Bern, Switzerland"},{"name":"Hearing Research Laboratory, ARTORG Center for Biomedical Engineering Research, University of Bern, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Anschuetz","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Bern University Hospital, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3804-1452","authenticated-orcid":false,"given":"D. A.","family":"Hall","sequence":"additional","affiliation":[{"name":"National Institute for Health Research Nottingham Biomedical Research Centre, Nottingham, United Kingdom"},{"name":"Hearing Sciences, Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, United Kingdom"},{"name":"University of Nottingham Malaysia, Semenyih, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Caversaccio","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Bern University Hospital, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Wimmer","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Bern University Hospital, Bern, Switzerland"},{"name":"Hearing Research Laboratory, ARTORG Center for Biomedical Engineering Research, University of Bern, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,3,4]]},"reference":[{"key":"bibr1-2331216520986303","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2017.05.017"},{"key":"bibr2-2331216520986303","doi-asserted-by":"publisher","DOI":"10.3766\/jaaa.20.5.5"},{"key":"bibr3-2331216520986303","unstructured":"Archer K. J., Hedeker D., Nordgren R., Gibbons R. D. (2018).\n                      mixor: Mixed-effects ordinal regression analysis\n                      . R package version 1.0.4. R Foundation for Statistical Computing."},{"key":"bibr4-2331216520986303","doi-asserted-by":"publisher","DOI":"10.1163\/156856897X00357"},{"key":"bibr5-2331216520986303","doi-asserted-by":"publisher","DOI":"10.1097\/01.mao.0000178146.91139.3c"},{"key":"bibr6-2331216520986303","doi-asserted-by":"publisher","DOI":"10.1044\/2019_JSLHR-H-18-0514"},{"key":"bibr7-2331216520986303","doi-asserted-by":"publisher","DOI":"10.3109\/00206097109072551"},{"key":"bibr8-2331216520986303","doi-asserted-by":"publisher","DOI":"10.1177\/2331216518769996"},{"key":"bibr9-2331216520986303","doi-asserted-by":"publisher","DOI":"10.1007\/s10162-016-0601-9"},{"issue":"3","key":"bibr10-2331216520986303","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1055\/s-0042-1748040","volume":"11","author":"Henry J. 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A. & Meikle, M. B. (2003). Tinnitus: Clinical measurement.\n                      Otolaryngologic Clinics of North America, 36\n                      (2), 293-305.","DOI":"10.1016\/S0030-6665(02)00162-7"},{"key":"bibr32-2331216520986303","unstructured":"Vernon, J. A. (1981). Some observations on residual inhibition. In M. M. Paparella & W. L. Meyerhoff (Eds.),\n                      Sensorineural hearing loss, vertigo and tinnitus\n                      (Ear clinics international) (Vol. 1, pp. 138-144). 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