{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T15:39:27Z","timestamp":1782833967724,"version":"3.54.5"},"reference-count":65,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"DFG Cluster of Excellence","award":["EXC 1077 1 Hearing4all"],"award-info":[{"award-number":["EXC 1077 1 Hearing4all"]}]},{"name":"European Research Council","award":["678120 RobSpear"],"award-info":[{"award-number":["678120 RobSpear"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Trends in Hearing"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Over the past decades, different types of auditory models have been developed to study the functioning of normal and impaired auditory processing. Several models can simulate frequency-dependent sensorineural hearing loss (SNHL) and can in this way be used to develop personalized audio-signal processing for hearing aids. However, to determine individualized SNHL profiles, we rely on indirect and noninvasive markers of cochlear and auditory-nerve (AN) damage. Our progressive knowledge of the functional aspects of different SNHL subtypes stresses the importance of incorporating them into the simulated SNHL profile, but has at the same time complicated the task of accomplishing this on the basis of noninvasive markers. In particular, different auditory-evoked potential (AEP) types can show a different sensitivity to outer-hair-cell (OHC), inner-hair-cell (IHC), or AN damage, but it is not clear which AEP-derived metric is best suited to develop personalized auditory models. This study investigates how simulated and recorded AEPs can be used to derive individual AN- or OHC-damage patterns and personalize auditory processing models. First, we individualized the cochlear model parameters using common methods of frequency-specific OHC-damage quantification, after which we simulated AEPs for different degrees of AN damage. Using a classification technique, we determined the recorded AEP metric that best predicted the simulated individualized cochlear synaptopathy profiles. We cross-validated our method using the data set at hand, but also applied the trained classifier to recorded AEPs from a new cohort to illustrate the generalizability of the method.<\/jats:p>","DOI":"10.1177\/2331216520988406","type":"journal-article","created":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T02:36:32Z","timestamp":1612233392000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Towards Personalized Auditory Models: Predicting Individual Sensorineural Hearing-Loss Profiles From Recorded Human Auditory Physiology"],"prefix":"10.1177","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0081-8243","authenticated-orcid":false,"given":"Sarineh","family":"Keshishzadeh","sequence":"first","affiliation":[{"name":"Hearing Technology @ WAVES, Department of Information Technology, Ghent University, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0115-5288","authenticated-orcid":false,"given":"Markus","family":"Garrett","sequence":"additional","affiliation":[{"name":"Medizinische Physik and Cluster of Excellence Hearing4all, Department of Medical Physics and Acoustics, University of Oldenburg, Oldenburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Verhulst","sequence":"additional","affiliation":[{"name":"Hearing Technology @ WAVES, Department of Information Technology, Ghent University, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,2,1]]},"reference":[{"key":"bibr1-2331216520988406","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2014.01.011"},{"key":"bibr2-2331216520988406","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2014.00026"},{"key":"bibr3-2331216520988406","doi-asserted-by":"publisher","DOI":"10.1121\/1.1460923"},{"key":"bibr4-2331216520988406","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2019.02.016"},{"key":"bibr5-2331216520988406","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.12.041"},{"key":"bibr6-2331216520988406","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2008.05.008"},{"key":"bibr7-2331216520988406","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1977.00780270073012"},{"key":"bibr8-2331216520988406","doi-asserted-by":"publisher","DOI":"10.1121\/1.381816"},{"key":"bibr9-2331216520988406","doi-asserted-by":"publisher","DOI":"10.3109\/01050398709042155"},{"key":"bibr10-2331216520988406","doi-asserted-by":"publisher","DOI":"10.3109\/01050399609047559"},{"key":"bibr11-2331216520988406","doi-asserted-by":"publisher","DOI":"10.1121\/1.1288665"},{"key":"bibr12-2331216520988406","doi-asserted-by":"crossref","unstructured":"Ewert S. D., Kortlang S., Hohmann V. (2013).\n                      A model-based hearing aid: Psychoacoustics, models and algorithms\n                      [Paper presentation]. Meetings on Acoustics ICA2013 (vol. 19, p. 050187). Acoustical Society of America. https:\/\/doi.org\/10.1121\/1.4798816","DOI":"10.1121\/1.4798816"},{"key":"bibr13-2331216520988406","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00164.2013"},{"key":"bibr14-2331216520988406","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2019.07.001"},{"key":"bibr15-2331216520988406","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00730"},{"key":"bibr16-2331216520988406","doi-asserted-by":"crossref","unstructured":"Garrett M., Vasilkov V., Mauermann M., Wilson J. L., Henry K. S., Verhulst S. (2020). Speech-in-noise intelligibility difficulties with age: The role of cochlear synaptopathy.\n                      bioRxiv\n                      . https:\/\/doi.org\/10.1101\/2020.06.09.142950","DOI":"10.1101\/2020.06.09.142950"},{"key":"bibr17-2331216520988406","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2016.00133"},{"key":"bibr18-2331216520988406","doi-asserted-by":"publisher","DOI":"10.1097\/00003446-198503000-00008"},{"key":"bibr19-2331216520988406","doi-asserted-by":"publisher","DOI":"10.1007\/s10162-012-0344-1"},{"key":"bibr20-2331216520988406","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2018.03.008"},{"key":"bibr21-2331216520988406","doi-asserted-by":"publisher","DOI":"10.1121\/1.1387155"},{"key":"bibr22-2331216520988406","doi-asserted-by":"publisher","DOI":"10.1007\/s10162-018-0671-y"},{"key":"bibr23-2331216520988406","doi-asserted-by":"publisher","DOI":"10.3109\/14992020309078343"},{"key":"bibr24-2331216520988406","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00184.2013"},{"key":"bibr25-2331216520988406","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2016.12.010"},{"key":"bibr26-2331216520988406","doi-asserted-by":"publisher","DOI":"10.1121\/1.3518768"},{"key":"bibr27-2331216520988406","doi-asserted-by":"publisher","DOI":"10.1121\/1.2924135"},{"key":"bibr28-2331216520988406","unstructured":"Keshishzadeh S., Verhulst S. (2019).\n                      From derived-band envelope-following responses to individualized models of near-and supra-threshold hearing deficits\n                      [Paper presentation]. Proceedings of the International Symposium on Auditory and Audiological Research (vol. 7, pP. 13\u201320). https:\/\/proceedings.isaar.eu\/index.php\/isaarproc\/article\/view\/2019-02"},{"key":"bibr29-2331216520988406","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2020.107979"},{"key":"bibr30-2331216520988406","doi-asserted-by":"publisher","DOI":"10.1080\/14992020400022561"},{"key":"bibr31-2331216520988406","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2845-09.2009"},{"key":"bibr32-2331216520988406","doi-asserted-by":"publisher","DOI":"10.1121\/1.423054"},{"key":"bibr33-2331216520988406","doi-asserted-by":"publisher","DOI":"10.1121\/1.381736"},{"key":"bibr34-2331216520988406","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0162726"},{"key":"bibr35-2331216520988406","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2013.03.012"},{"key":"bibr36-2331216520988406","doi-asserted-by":"publisher","DOI":"10.1121\/1.2949505"},{"key":"bibr37-2331216520988406","doi-asserted-by":"publisher","DOI":"10.1121\/1.3050304"},{"key":"bibr38-2331216520988406","doi-asserted-by":"crossref","unstructured":"Mauermann M. (2013).\n                      Improving the usability of the distortion product otoacoustic emissions (DPOAE)-sweep method: An alternative artifact rejection and noise-floor estimation\n                      [Paper presentation]. Meetings on Acoustics ICA2013 (vol. 19, p. 050054). Acoustical Society of America.  https:\/\/doi.org\/10.1121\/1.4800902","DOI":"10.1121\/1.4800902"},{"key":"bibr39-2331216520988406","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(89)90101-9"},{"key":"bibr40-2331216520988406","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2016.05.001"},{"key":"bibr41-2331216520988406","unstructured":"Osses A. & Verhulst, S. (2019). Calibration and reference simulations for the auditory periphery model of Verhulst et\u00a0al. 2018 version 1.2.\n                      arXiv preprint arXiv, 1912.10026\n                      ."},{"key":"bibr42-2331216520988406","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3240-17.2018"},{"key":"bibr43-2331216520988406","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2018.12.007"},{"key":"bibr44-2331216520988406","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2018.08.023"},{"key":"bibr45-2331216520988406","doi-asserted-by":"publisher","DOI":"10.1177\/2331216516657466"},{"key":"bibr46-2331216520988406","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2018.04.002"},{"key":"bibr47-2331216520988406","doi-asserted-by":"publisher","DOI":"10.1121\/1.1798354"},{"key":"bibr48-2331216520988406","unstructured":"Rohdenburg T., Hohmann V., Kollmeier B. (2005).\n                      Objective perceptual quality measures for the evaluation of noise reduction schemes\n                      [Paper presentation]. 9th International Workshop on Acoustic Echo and Noise Control (pp. 169\u2013172)."},{"key":"bibr49-2331216520988406","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2156-11.2011"},{"key":"bibr50-2331216520988406","doi-asserted-by":"publisher","DOI":"10.1136\/oem.2004.018143"},{"key":"bibr51-2331216520988406","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1783-13.2013"},{"key":"bibr52-2331216520988406","doi-asserted-by":"publisher","DOI":"10.1007\/s10162-015-0539-3"},{"key":"bibr53-2331216520988406","doi-asserted-by":"publisher","DOI":"10.1097\/AUD.0000000000000107"},{"key":"bibr54-2331216520988406","unstructured":"Trautwein P. (2002, November 8\u201310).\n                      Auditory neuropathy: Diagnosis and case management\n                      [Paper presentation]. 4th ACFOS International Conference (pp. 8\u201310, Paris, France)."},{"key":"bibr55-2331216520988406","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(88)90088-3"},{"key":"bibr56-2331216520988406","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2017.07.003"},{"key":"bibr57-2331216520988406","doi-asserted-by":"crossref","unstructured":"Vasilkov V., Verhulst S. (2019). Towards a differential diagnosis of cochlear synaptopathy and outer-hair-cell deficits in mixed sensorineural hearing loss pathologies.\n                      medRxiv\n                      , 19008680. https:\/\/doi.org\/10.1101\/19008680","DOI":"10.1101\/19008680"},{"key":"bibr58-2331216520988406","doi-asserted-by":"crossref","unstructured":"Vasilkov V., Garrett M., Mauermann M., Verhulst S. (2021). Enhancing the sensitivity of the envelope-following response for cochlear synaptopathy screening in humans: The role of stimulus envelope.\n                      Hearing Research\n                      ,\n                      400\n                      , 108132. https:\/\/doi.org\/10.1016\/j.heares.2020.108132","DOI":"10.1016\/j.heares.2020.108132"},{"key":"bibr59-2331216520988406","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2017.12.018"},{"key":"bibr60-2331216520988406","doi-asserted-by":"publisher","DOI":"10.1121\/1.4763989"},{"key":"bibr61-2331216520988406","doi-asserted-by":"publisher","DOI":"10.1177\/2331216516672186"},{"key":"bibr62-2331216520988406","doi-asserted-by":"publisher","DOI":"10.3109\/00206099609071945"},{"key":"bibr63-2331216520988406","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0937-20.2020"},{"key":"bibr64-2331216520988406","doi-asserted-by":"publisher","DOI":"10.1121\/1.4807498"},{"key":"bibr65-2331216520988406","doi-asserted-by":"publisher","DOI":"10.1121\/1.2225512"}],"container-title":["Trends in Hearing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2331216520988406","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2331216520988406","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2331216520988406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:45:56Z","timestamp":1777596356000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2331216520988406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":65,"alternative-id":["10.1177\/2331216520988406"],"URL":"https:\/\/doi.org\/10.1177\/2331216520988406","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.11.17.387001","asserted-by":"object"}]},"ISSN":["2331-2165","2331-2165"],"issn-type":[{"value":"2331-2165","type":"print"},{"value":"2331-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"article-number":"2331216520988406"}}