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Temporal processing abilities may decline with advancing age in adult CI users. This study investigated the effect of age on the ability to discriminate changes in pulse rate. Twenty CI users aged 23 to 80\u2009years participated in a rate discrimination task. They attempted to discriminate a 35% rate increase from baseline rates of 100, 200, 300, 400, or 500 pulses per second. The stimuli were electrical pulse trains delivered to a single electrode via direct stimulation to an apical (Electrode 20), a middle (Electrode 12), or a basal location (Electrode 4). Electrically evoked compound action potential amplitude growth functions were recorded at each of those electrodes as an estimate of peripheral neural survival. Results showed that temporal pulse rate discrimination performance declined with advancing age at higher stimulation rates (e.g., 500 pulses per second) when compared with lower rates. The age-related changes in temporal pulse rate discrimination at higher stimulation rates persisted after statistical analysis to account for the estimated peripheral contributions from electrically evoked compound action potential amplitude growth functions. These results indicate the potential contributions of central factors to the limitations in temporal pulse rate discrimination ability associated with aging in CI users.<\/jats:p>","DOI":"10.1177\/23312165211007367","type":"journal-article","created":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T11:37:52Z","timestamp":1621856272000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Effect of Chronological Age on Pulse Rate Discrimination in Adult Cochlear-Implant Users"],"prefix":"10.1177","volume":"25","author":[{"given":"Kelly C.","family":"Johnson","sequence":"first","affiliation":[{"name":"Department of Hearing and Speech Sciences, University of Maryland, College Park, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6851-7554","authenticated-orcid":false,"given":"Zilong","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Hearing and Speech, University of Kansas Medical Center, Kansas City, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4284-2738","authenticated-orcid":false,"given":"Maureen J.","family":"Shader","sequence":"additional","affiliation":[{"name":"Department of Hearing and Speech Sciences, University of Maryland, College Park, United States"},{"name":"Bionics Institute, Melbourne, Australia"},{"name":"Department of Medical Bionics, The University of Melbourne, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul G.","family":"Mayo","sequence":"additional","affiliation":[{"name":"Department of Hearing and Speech Sciences, University of Maryland, College Park, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2662-3057","authenticated-orcid":false,"given":"Matthew J.","family":"Goupell","sequence":"additional","affiliation":[{"name":"Department of Hearing and Speech Sciences, University of Maryland, College Park, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,5,24]]},"reference":[{"key":"bibr1-23312165211007367","doi-asserted-by":"publisher","DOI":"10.1121\/1.4799804"},{"key":"bibr2-23312165211007367","doi-asserted-by":"publisher","DOI":"10.1007\/s10162-020-00753-4"},{"key":"bibr3-23312165211007367","doi-asserted-by":"publisher","DOI":"10.1007\/s10162-011-0294-z"},{"key":"bibr4-23312165211007367","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.24639"},{"issue":"7","key":"bibr5-23312165211007367","first-page":"1","volume":"1","author":"Bates D.","year":"2014","journal-title":"R package Version"},{"key":"bibr6-23312165211007367","doi-asserted-by":"publisher","DOI":"10.1007\/s10162-018-00710-2"},{"key":"bibr7-23312165211007367","doi-asserted-by":"publisher","DOI":"10.1177\/2331216516655793"},{"key":"bibr8-23312165211007367","doi-asserted-by":"publisher","DOI":"10.1097\/AUD.0b013e3181cb41aa"},{"key":"bibr9-23312165211007367","doi-asserted-by":"publisher","DOI":"10.1186\/1475-925X-8-40"},{"key":"bibr10-23312165211007367","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000001245"},{"key":"bibr11-23312165211007367","doi-asserted-by":"publisher","DOI":"10.1121\/1.1496766"},{"key":"bibr13-23312165211007367","doi-asserted-by":"publisher","DOI":"10.1121\/1.4934275"},{"key":"bibr14-23312165211007367","doi-asserted-by":"publisher","DOI":"10.1121\/1.3291981"},{"key":"bibr16-23312165211007367","doi-asserted-by":"publisher","DOI":"10.1121\/1.3372711"},{"key":"bibr17-23312165211007367","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610215001982"},{"key":"bibr18-23312165211007367","unstructured":"Centers for Disease Control and Prevention. 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Assessing the Electrode-Neuron Interface with the Electrically Evoked Compound Action Potential, Electrode Position, and Behavioral Thresholds.\n                      Journal of the Association for Research in Otolaryngology : JARO, 17\n                      (3), 237-252. https:\/\/doi.org\/10.1007\/s10162-016-0557-9","DOI":"10.1007\/s10162-016-0557-9"},{"key":"bibr24-23312165211007367","doi-asserted-by":"publisher","DOI":"10.1121\/1.5042082"},{"key":"bibr2511-23312165211007367","doi-asserted-by":"crossref","unstructured":"Gaudrain, E., Deeks, J. M. & Carlyon, R. P. (2017). Temporal Regularity Detection and Rate Discrimination in Cochlear-Implant Listeners.\n                      Journal of the Association for Research in Otolaryngology: JARO, 18\n                      (2), 387-397. https:\/\/doi.org\/10.1007\/s10162-016-0586-4","DOI":"10.1007\/s10162-016-0586-4"},{"key":"bibr25-23312165211007367","doi-asserted-by":"publisher","DOI":"10.1044\/2018_JSLHR-H-ASCC7-18-0133"},{"key":"bibr26-23312165211007367","doi-asserted-by":"publisher","DOI":"10.1121\/1.4835735"},{"key":"bibr27-23312165211007367","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2010.05.005"},{"key":"bibr28-23312165211007367","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-0993-0"},{"key":"bibr29-23312165211007367","doi-asserted-by":"publisher","DOI":"10.4081\/audiores.2011.e4"},{"key":"bibr30-23312165211007367","doi-asserted-by":"publisher","DOI":"10.1097\/AUD.0000000000000447"},{"key":"bibr31-23312165211007367","doi-asserted-by":"publisher","DOI":"10.1121\/1.2981638"},{"key":"bibr32-23312165211007367","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(90)90102-U"},{"key":"bibr33-23312165211007367","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2017.01.008"},{"key":"bibr34-23312165211007367","doi-asserted-by":"publisher","DOI":"10.1121\/1.2035593"},{"key":"bibr36-23312165211007367","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2017.00339"},{"key":"bibr38-23312165211007367","doi-asserted-by":"publisher","DOI":"10.1121\/1.3585848"},{"key":"bibr39-23312165211007367","doi-asserted-by":"publisher","DOI":"10.4324\/9781315650982"},{"key":"bibr40-23312165211007367","volume-title":"Objective measures in cochlear implants","author":"Hughes M. 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N. & Arenberg, J.G. (2020). Electrophysiological estimates of the electrode-neuron interface differ between younger and older listeners with cochlear implants.\n                      Ear Hear\n                      ,\n                      41\n                      (4), 948-960. DOI: 10.1097\/AUD.0000000000000827","DOI":"10.1097\/AUD.0000000000000827"},{"key":"bibr45-23312165211007367","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-017-1181-7"},{"key":"bibr46-23312165211007367","first-page":"656","volume":"26","author":"Jin S. 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J., Gordon-Salant, S. & Goupell, M. J. (2020a). The impact of aging and peripheral neural survival on temporal processing ability in cochlear-implant users: Amplitude modulation detection thresholds.\n                      Trends in Hearing, 24\n                      , 2331216520936160.  https:\/\/doi.org\/10.1177\/2331216520936160","DOI":"10.1177\/2331216520936160"},{"key":"bibr78-23312165211007367","doi-asserted-by":"publisher","DOI":"10.1177\/2331216520956560"},{"key":"bibr79-23312165211007367","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(97)00046-4"},{"key":"bibr80-23312165211007367","doi-asserted-by":"publisher","DOI":"10.1177\/000348948309200105"},{"key":"bibr81-23312165211007367","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2019.07.004"},{"key":"bibr82-23312165211007367","doi-asserted-by":"publisher","DOI":"10.1121\/1.395554"},{"key":"bibr83-23312165211007367","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e3181f24005"},{"key":"bibr84-23312165211007367","doi-asserted-by":"publisher","DOI":"10.1080\/14670100.2016.1240427"},{"key":"bibr85-23312165211007367","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-07-02764.1998"},{"key":"bibr86-23312165211007367","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0140920"},{"key":"bibr87-23312165211007367","doi-asserted-by":"publisher","DOI":"10.1177\/2331216519886688"},{"key":"bibr88-23312165211007367","doi-asserted-by":"publisher","DOI":"10.1001\/archpediatrics.2011.574"},{"key":"bibr89-23312165211007367","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(02)00644-5"},{"key":"bibr90-23312165211007367","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0084631"},{"key":"bibr91-23312165211007367","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2018.10.018"}],"container-title":["Trends in Hearing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/23312165211007367","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/23312165211007367","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/23312165211007367","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:46:01Z","timestamp":1777596361000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/23312165211007367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":91,"alternative-id":["10.1177\/23312165211007367"],"URL":"https:\/\/doi.org\/10.1177\/23312165211007367","relation":{},"ISSN":["2331-2165","2331-2165"],"issn-type":[{"value":"2331-2165","type":"print"},{"value":"2331-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"article-number":"23312165211007367"}}