{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T08:00:59Z","timestamp":1777881659355,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Cochlear Americas"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Trends in Hearing"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>This multi-center study examined the safety and effectiveness of cochlear implantation of children between 9 and 11 months of age. The intended impact was to support practice regarding candidacy assessment and prognostic counseling of pediatric cochlear implant candidates. Data in the clinical chart of children implanted at 9\u201311 months of age with Cochlear Ltd devices at five cochlear implant centers in the United States and Canada were included in analyses. The study included data from two cohorts implanted with one or two Nucleus devices during the periods of January 1, 2012\u2013December 31, 2017 (Cohort 1, n\u2009=\u200983) or between January 1, 2018 and May 15, 2020 (Cohort 2, n\u2009=\u200950). Major adverse events (requiring another procedure\/hospitalization) and minor adverse events (managed with medication alone or underwent an expected course of treatment that did not require surgery or hospitalization) out to 2 years post-implant were monitored and outcomes measured by audiometric thresholds and parent-reports on the IT-MAIS and LittlEARS questionnaires were collected. Results revealed 60 adverse events in 41 children and 227 ears implanted (26%) of which 14 major events occurred in 11 children; all were transitory and resolved. Improved hearing with cochlear implant use was shown in all outcome measures. Findings reveal that the procedure is safe for infants and that they show clear benefits of cochlear implantation including increased audibility and hearing development.<\/jats:p>","DOI":"10.1177\/23312165241261480","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T03:44:18Z","timestamp":1718682258000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Safety and Early Outcomes of Cochlear Implantation of Nucleus Devices in Infants: A Multi-Centre Study"],"prefix":"10.1177","volume":"28","author":[{"given":"Tal","family":"Honigman","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, The Hospital for Sick Children, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon L.","family":"Cushing","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, The Hospital for Sick Children, Toronto, ON, Canada"},{"name":"Department of Otolaryngology-Head & Neck Surgery, University of Toronto, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blake C.","family":"Papsin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, The Hospital for Sick Children, Toronto, ON, Canada"},{"name":"Department of Otolaryngology-Head & Neck Surgery, University of Toronto, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Waltzman","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, New York University Grossman School of Medicine, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Woodard","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\/Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Neumann","sequence":"additional","affiliation":[{"name":"Hearts for Hearing, Oklahoma City, OK, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew B.","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Stanford University, Palo Alto, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2491-3125","authenticated-orcid":false,"given":"Karen A.","family":"Gordon","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head & Neck Surgery, University of Toronto, Toronto, ON, Canada"},{"name":"Department of Communication Disorders, The Hospital for Sick Children, Toronto, ON, Canada"},{"name":"Program in Neuroscience and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,6,18]]},"reference":[{"key":"bibr1-23312165241261480","doi-asserted-by":"publisher","DOI":"10.1097\/AUD.0b013e3182503e47"},{"key":"bibr2-23312165241261480","author":"Cejas I.","journal-title":"JAMA Otolaryngology\u2013Head & Neck Surgery"},{"key":"bibr3-23312165241261480","doi-asserted-by":"publisher","DOI":"10.1080\/14992027.2017.1385865"},{"key":"bibr4-23312165241261480","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2011.01.005"},{"key":"bibr5-23312165241261480","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2009.09.036"},{"key":"bibr6-23312165241261480","doi-asserted-by":"publisher","DOI":"10.1044\/2022_JSLHR-22-00039"},{"key":"bibr7-23312165241261480","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e318214ea88"},{"key":"bibr8-23312165241261480","doi-asserted-by":"publisher","DOI":"10.1177\/23312165211014695"},{"key":"bibr9-23312165241261480","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000000915"},{"key":"bibr10-23312165241261480","doi-asserted-by":"publisher","DOI":"10.1016\/j.anorl.2013.05.005"},{"key":"bibr11-23312165241261480","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2015.06.003"},{"key":"bibr12-23312165241261480","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.130.5.634"},{"key":"bibr13-23312165241261480","doi-asserted-by":"publisher","DOI":"10.1002\/dev.20052"},{"key":"bibr14-23312165241261480","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000149456.75758.4c"},{"key":"bibr15-23312165241261480","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2013.05.021"},{"key":"bibr16-23312165241261480","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e3182814d2c"},{"key":"bibr17-23312165241261480","unstructured":"Lenth R. 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