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The latter has been posited to occur when descending analgesic pathways are attenuated and\/or glutamatergic transmission is facilitated. Additionally, this \u201cpain prone phenotype\u201d can be associated with early life trauma and a suboptimal response to opiates. This article will review the relationships between centralized pain syndromes (ie, fibromyalgia, chronic low back pain), childhood sexual abuse, and opiate misuse. Finally, treatment implications, potentially effecting primary care physicians, will be discussed. <\/jats:p>","DOI":"10.1177\/2333392814567920","type":"journal-article","created":{"date-parts":[[2015,1,13]],"date-time":"2015-01-13T04:41:25Z","timestamp":1421124085000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["A Review of Select Centralized Pain Syndromes"],"prefix":"10.1177","volume":"2","author":[{"given":"David R.","family":"Spiegel","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aparna","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aidan 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