{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T17:41:02Z","timestamp":1777657262319,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Global Pediatric Health"],"published-print":{"date-parts":[[2017,1]]},"abstract":"\n Background<\/jats:italic>\n . In all cases of suspected sexually transmitted infections (STIs), it has been routine practice to screen for syphilis with a blood sample. The incidence of syphilis seems to be lower than that of commonly screened STIs.\n Objective<\/jats:italic>\n . The objective of our study was to determine whether it is cost-effective to screen for syphilis with serological testing in cases of suspected gonorrhea and chlamydia infections.\n Hypothesis<\/jats:italic>\n . Our hypothesis is that it is not cost-effective to screen for syphilis in cases of presumed gonorrhea and chlamydia infections.\n Methods<\/jats:italic>\n . Our study is a New York Medical College institutional review board\u2013approved retrospective study. During the period January 2004 to August 12, 2006, the laboratory work of all patients tested for gonorrhea and chlamydia in our emergency department was reviewed. The charts were reviewed for the following tests: gonorrhea DNA probe, chlamydia DNA probe, and syphilis IgG (immunoglobulin G)\/RPR (rapid plasma reagin). The results of these tests were obtained and analyzed.\n Results<\/jats:italic>\n . The total number of patients screened for gonorrhea and chlamydia during this period was 196. Seventy-eight patients tested positive for gonorrhea and chlamydia. All these 78 patients, tested negative for syphilis. The overall prevalence of positivity for STIs was 39.8% (78\/196). The prevalence of chlamydia alone was 85.9% (67\/78) and gonorrhea alone was 7.69% (6\/78). The prevalence of combined both chlamydia and gonorrhea was 6.4% (5\/78).\n Statistics<\/jats:italic>\n . We used online SILICO 2 \u00d7 4 Fisher exact test. By comparing positive and negative results of serology RPR, GC, and chlamydia trap, the resultant 2-tailed\n P<\/jats:italic>\n value is <.0001, which is statistically significant.\n Conclusions<\/jats:italic>\n . Per our study, the yield of syphilis testing was negligible. It may not be cost-effective to screen for syphilis in cases of STIs such as gonorrhea and chlamydia.\n <\/jats:p>","DOI":"10.1177\/2333794x17719361","type":"journal-article","created":{"date-parts":[[2017,7,25]],"date-time":"2017-07-25T04:47:49Z","timestamp":1500958069000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Screening for Syphilis in Cases of Suspected Gonorrhea and Chlamydia Infections"],"prefix":"10.1177","volume":"4","author":[{"given":"Kumara V.","family":"Nibhanipudi","sequence":"first","affiliation":[{"name":"New York Medical College, Metropolitan Hospital Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"Cody","sequence":"additional","affiliation":[{"name":"New York Medical College, Metropolitan Hospital Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,7,12]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"Behrman RE Kliegman RM Jenson HB eds. Nelson Textbook of Pediatrics. Philadelphia PA: Saunders; 2002."},{"key":"e_1_3_3_3_2","unstructured":"Centers for Disease Control and Prevention. New CDC data show syphilis increasing in men: gonorrhea cases at all time low; chlamydia testing possibly increasing. https:\/\/www.cdc.gov\/media\/pressrel\/r051108.htm. Published November 8 2005. Accessed June 26 2017."},{"key":"e_1_3_3_4_2","unstructured":"US Preventive Services Task Force. Syphilis infection: screening. https:\/\/www.uspreventiveservicestaskforce.org\/Page\/Document\/UpdateSummaryFinal\/syphilis-infection-screening. Published July 2004. Accessed June 26 2017."},{"key":"e_1_3_3_5_2","article-title":"Treatment of uncomplicated gonococcal infections","author":"Swygard H","unstructured":"Swygard H, Sena AC, Cohen MS. Treatment of uncomplicated gonococcal infections. Up to Date. Published May 31, 2008. Accessed June 26, 2017.","journal-title":"Up to Date"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2008.05.001."},{"key":"e_1_3_3_7_2","first-page":"575","article-title":"Trends in primary and secondary syphilis and HIV infections in men who have sex with men\u2014San Francisco and Los Angeles, California, 1998-2002","volume":"53","author":"Centers for Disease Control and Prevention","year":"2004","unstructured":"Centers for Disease Control and Prevention. Trends in primary and secondary syphilis and HIV infections in men who have sex with men\u2014San Francisco and Los Angeles, California, 1998-2002. MMWR Morb Mortal Wkly Rep. 2004;53:575-578.","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_3_3_8_2","volume-title":"Program and abstracts of the Second National Conference on Human Retroviruses and Related Infections: Sheraton Washington Hotel, 29 January-2 February 1995, Washington, DC","author":"National Conference on Human Retroviruses and Related Infections","year":"1995","unstructured":"National Conference on Human Retroviruses and Related Infections. Program and abstracts of the Second National Conference on Human Retroviruses and Related Infections: Sheraton Washington Hotel, 29 January-2 February 1995, Washington, DC. Washington, DC: American Society of Microbiology; 1995."},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2014-051670."},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004711."},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/0956462416636727."},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ucl.2015.06.004."},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2014-051891."},{"key":"e_1_3_3_14_2","unstructured":"Centers for Disease Control and Prevention. Sexually transmitted diseases surveillance 2014. https:\/\/www.cdc.gov\/std\/stats14\/surv-2014-print.pdf. Accessed June 26 2017."},{"key":"e_1_3_3_15_2","unstructured":"Centers for Disease Control and Prevention. Reported cases of sexually transmitted diseases on the rise some at alarming rate. https:\/\/www.cdc.gov\/nchhstp\/newsroom\/2015\/std-surveillance-report-press-release.html. Published November 17 2015. Accessed June 26 2017."}],"container-title":["Global Pediatric Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2333794X17719361","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2333794X17719361","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2333794X17719361","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:08:24Z","timestamp":1777446504000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2333794X17719361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":14,"alternative-id":["10.1177\/2333794X17719361"],"URL":"https:\/\/doi.org\/10.1177\/2333794x17719361","relation":{},"ISSN":["2333-794X","2333-794X"],"issn-type":[{"value":"2333-794X","type":"print"},{"value":"2333-794X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1]]},"article-number":"2333794X17719361"}}