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This was a cross-sectional, liver biopsy validation pilot study of 16 participants evaluating the ability of shear wave elastography, aspartate transaminase to platelet ratio index (APRI), fibrosis index based on the 4 factors, and novel serum biomarkers to stage liver fibrosis in children with chronic hepatitis B or C. There was very high intrasegmental shear wave speed variation in our participants and little correlation with fibrosis. APRI and monocyte chemoattractant protein (MCP-1) were higher in fibrosis stage F2-3 versus F0-1 ( P = .02, P = .06, respectively). Soluble Fas (sFas) was lower in F2-3 versus F0-1 ( P = .046). A logistic regression analysis calculated by (APRI \u00d7 MCP-1)\/sFas demonstrated an area under the receiver operating characteristic curve of 0.92 ( P &lt; .001), suggesting that this combination can differentiate fibrosis stage F0-1 from F2-3 in children with chronic viral hepatitis.<\/jats:p>","DOI":"10.1177\/2333794x20938931","type":"journal-article","created":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T06:54:49Z","timestamp":1596092089000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["A Liver Biopsy Validation Pilot Study of Shear Wave Elastography, APRI, FIB-4, and Novel Serum Biomarkers for Liver Fibrosis Staging in Children With Chronic Viral Hepatitis"],"prefix":"10.1177","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0855-090X","authenticated-orcid":false,"given":"Rebecca","family":"Mercedes","sequence":"first","affiliation":[{"name":"Baylor College of Medicine, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jameisha","family":"Brown","sequence":"additional","affiliation":[{"name":"Texas A&M University System, College Station, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Minard","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia M.","family":"Tsai","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine, Houston, TX, USA"},{"name":"Texas Children\u2019s Hospital, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sridevi","family":"Devaraj","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marthe","family":"Munden","sequence":"additional","affiliation":[{"name":"Wake Forest Baptist Medical Center, Winston-Salem, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Leung","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine, Houston, TX, USA"},{"name":"Texas Children\u2019s Hospital, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,7,30]]},"reference":[{"key":"bibr1-2333794X20938931","doi-asserted-by":"publisher","DOI":"10.1177\/0091270003258669"},{"key":"bibr2-2333794X20938931","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0801644"},{"key":"bibr3-2333794X20938931","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2017.01.007"},{"key":"bibr4-2333794X20938931","unstructured":"Centers for Disease Control and Prevention. 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