{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T04:59:50Z","timestamp":1778216390033,"version":"3.51.4"},"reference-count":44,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Soci\u00e9t\u00e9 des Produits Nestl\u00e9 S.A."}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Global Pediatric Health"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Signs of feeding intolerance are common in formula-fed infants. We evaluated the clinical response to a partially hydrolyzed 100% whey protein formula with high sn-2 palmitate and reduced lactose (FA) and to an alpha-lactalbumin-enriched whey-predominant intact protein formula with full lactose (FB) in healthy full-term infants with parent-reported signs of feeding intolerance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In a double-blind, parallel-group trial in 6 Asian study centers, exclusively formula-fed infants aged 30 to 90\u2009days, whose parents reported fussiness-crying for \u22652\u2009hours\/day plus gassiness and\/or stooling difficulty, and intended to switch formula, were randomly assigned to FA (n\u2009=\u2009130) or FB (n\u2009=\u2009129) for 14\u2009days. Primary endpoint was daily duration of fussiness-crying. Secondary endpoints included gassiness, spitting-up, vomiting, sleep pattern, Infant Gastrointestinal Symptom Questionnaire (IGSQ) Index, infant temperament and maternal anxiety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Mean\u2009\u00b1\u2009SE minutes\/day of fussiness-crying in the 256 analyzed infants (FA, n\u2009=\u2009127 and FB, n\u2009=\u2009129) substantially decreased from baseline to study end in FA (291\u2009\u00b1\u200914 to 140\u2009\u00b1\u20098; \u201352%, P\u2009&lt;\u2009.001), and FB (313\u2009\u00b1\u200914 to 153\u2009\u00b1\u200911, \u201351%, P\u2009&lt;\u2009.001) with no difference between groups. Similarly, gassiness, spitting-up, vomiting and sleep pattern significantly improved by study end for both formulas. Mean\u2009\u00b1\u2009SE IGSQ index scores significantly decreased from baseline to study end (FA: 44.5\u2009\u00b1\u20090.9 to 28.6\u2009\u00b1\u20090.7; FB: 44.5\u2009\u00b1\u20090.8 to 29.0\u2009\u00b1\u20090.7; P\u2009&lt;\u2009.001) with no differences between groups. Infant temperament and maternal anxiety also improved significantly in both groups by study end.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Switching from standard, full-lactose, intact whey\/casein infant formulas to either study formula resulted in an improvement of gastrointestinal symptoms and associated behaviors in infants with signs of feeding intolerance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration:<\/jats:title>\n                    <jats:p>https:\/\/clinicaltrials.gov , NCT02021058<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2333794x20954332","type":"journal-article","created":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T08:38:31Z","timestamp":1601023111000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Clinical Response to Two Formulas in Infants with Parent-Reported Signs of Formula Intolerance: A Multi-Country, Double-Blind, Randomized Trial"],"prefix":"10.1177","volume":"7","author":[{"given":"Boosba","family":"Vivatvakin","sequence":"first","affiliation":[{"name":"Chulalongkorn University, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elvira","family":"Estorninos","sequence":"additional","affiliation":[{"name":"Asian Hospital and Medical Center, Muntinlupa City, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reyin","family":"Lien","sequence":"additional","affiliation":[{"name":"Chang Gung Memorial Hospital, Taoyuan, 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Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1689-1173","authenticated-orcid":false,"given":"Sheri","family":"Volger","sequence":"additional","affiliation":[{"name":"Nestl\u00e9 Product Technology Center \u2013 Nutrition, Soci\u00e9t\u00e9 des Produits Nestl\u00e9 S.A., Vevey, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,9,25]]},"reference":[{"key":"bibr1-2333794X20954332","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2005.01.009"},{"key":"bibr2-2333794X20954332","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000949"},{"key":"bibr3-2333794X20954332","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(02)00752-9"},{"key":"bibr4-2333794X20954332","doi-asserted-by":"crossref","first-page":"248","DOI":"10.3748\/wjg.14.248","volume":"14","author":"Infante Pina D","year":"2008","journal-title":"World J 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