{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T01:11:15Z","timestamp":1780103475081,"version":"3.54.0"},"reference-count":37,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Global Pediatric Health"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>Due to lack of robust data on childhood cystic fibrosis (CF) in Bangladesh we sought to evaluate their clinico-epidemiology. A cross-sectional observation was conducted adopting CF-foundation consensus-panel-diagnostic criteria in 3 tertiary-care-hospitals in Bangladesh from 2000 to 2017. Clinically suspected 95 CF-cases were subjected to sweat-chloride testing using locally-developed a fast, cheap and effective indigenously body-wrapped sweating technique measured by US-Easy Lyte-automated microprocessor-controlled analyzer marking \u226560\u2009mmol\/L as positive. Mean-age of CF-cases at disease-onset was 16.9\u2009\u00b1\u200926.6\u2009months that significantly differed with age-at-diagnosis ( P\u2009&lt;\u2009.02). Pulmonary syndromes included chronic wet cough in 100%, respiratory distress in 90.5%, digital-clubbing in 78%, mucopurulent-sputum in 74%-cases, and crepitation in 82%. Radio-imaging revealed bronchiectasis in 60%, hyperinflation\/peribronchial-thickening in 22% and, pan-sinusitis in 89%-cases. While 37% had history-of malabsorption, high-fecal-fat revealed in 53%-cases. Malnutrition prevailed as severe-underweight in 87%-cases and all CF-cases (100%) had high sweat-chloride (mean\u2009=\u2009118\u2009\u00b1\u200953.34\u2009mmol\/L). Thus, children with pulmonary features coupled with severe malnutrition and associated radio-imaging bronchiectasis should be screened for CF with a fast, cheap and effective sweat test in resource poor settings.<\/jats:p>","DOI":"10.1177\/2333794x20967585","type":"journal-article","created":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T05:42:26Z","timestamp":1604036546000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Cystic Fibrosis Diagnosed Using Indigenously Wrapped Sweating Technique: First Large-Scale Study Reporting Socio-Demographic, Clinical, and Laboratory Features among the Children in Bangladesh A Lower Middle Income Country"],"prefix":"10.1177","volume":"7","author":[{"given":"ARM Luthful","family":"Kabir","sequence":"first","affiliation":[{"name":"Ad-din Women\u2019s Medical College Hospital, Dhaka, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudipta","family":"Roy","sequence":"additional","affiliation":[{"name":"Ad-din Women\u2019s Medical College Hospital, Dhaka, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahat Bin","family":"Habib","sequence":"additional","affiliation":[{"name":"Director General Health Services, Dhaka, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazi Selim","family":"Anwar","sequence":"additional","affiliation":[{"name":"IUHW, Narita, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Abid Hossain","family":"Mollah","sequence":"additional","affiliation":[{"name":"Dhaka Medical College, Dhaka, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruhul","family":"Amin","sequence":"additional","affiliation":[{"name":"Institute of Child Health (BICH), Dhaka, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Al Amin","family":"Mridha","sequence":"additional","affiliation":[{"name":"Shaheed Shuhrawardy Medical College, Dhaka, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasim Uddin","family":"Majumder","sequence":"additional","affiliation":[{"name":"East West Medical College, Dhaka, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Delwar","family":"Hossain","sequence":"additional","affiliation":[{"name":"Institute of Child and Mother Health (ICMH), Dhaka, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazmul","family":"Haque","sequence":"additional","affiliation":[{"name":"Dhaka Medical College, Dhaka, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shakil","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Shaheed Shuhrawardy Medical College, Dhaka, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammod Jobayer","family":"Chisti","sequence":"additional","affiliation":[{"name":"International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,10,30]]},"reference":[{"key":"bibr1-2333794X20967585","doi-asserted-by":"publisher","DOI":"10.1126\/science.2475911"},{"key":"bibr2-2333794X20967585","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2013.188"},{"key":"bibr3-2333794X20967585","author":"WHO genes and human disease","year":"2010","journal-title":"Woo Int"},{"key":"bibr4-2333794X20967585","unstructured":"Sharma GB. 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