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The first hospitalization occurred before 12\u2009months in 38.6% and the average hospital admission per child was 3.92. The mean duration per hospitalization was 5.36\u2009days. The most common diagnosis was vaso-occlusive crisis (36.8%) followed by fever, upper airway infections, bacterial pneumonia and splenic sequestration. Hemoglobin values at admission were between 6 and 7\u2009g\/dL in 22.3%, with 44.2% requiring at least 1 blood transfusion. There are several acute complications of SCD, being vaso-occlusive crisis the most common. Splenic sequestration generally occurs during the first 2\u2009years and is associated with the need of transfusion. They represent a significant burden, with each child spending approximately 3\u2009weeks hospitalized.<\/jats:p>","DOI":"10.1177\/2333794x221141356","type":"journal-article","created":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T05:46:35Z","timestamp":1670478395000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Acute Complications of Sickle Cell Disease in Children Under 5\u2009Years at a Level II Hospital"],"prefix":"10.1177","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4574-7119","authenticated-orcid":false,"given":"Joana","family":"Lage","sequence":"first","affiliation":[{"name":"Hospital Professor Doutor Fernando Fonseca, Amadora, Lisboa, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernardo","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Hospital Professor Doutor Fernando Fonseca, Amadora, Lisboa, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Costa","sequence":"additional","affiliation":[{"name":"Hospital Professor Doutor Fernando Fonseca, Amadora, Lisboa, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00eas Filipa","family":"Mendes","sequence":"additional","affiliation":[{"name":"Hospital Professor Doutor Fernando Fonseca, Amadora, Lisboa, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Hospital Professor Doutor Fernando Fonseca, Amadora, Lisboa, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena Cristina","family":"Loureiro","sequence":"additional","affiliation":[{"name":"Hospital Professor Doutor Fernando Fonseca, Amadora, Lisboa, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,12,8]]},"reference":[{"key":"bibr1-2333794X221141356","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2013.09.006"},{"key":"bibr2-2333794X221141356","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61029-X"},{"key":"bibr3-2333794X221141356","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(92)90073-v.45:893"},{"key":"bibr4-2333794X221141356","doi-asserted-by":"publisher","DOI":"10.1177\/000992288102000501"},{"key":"bibr5-2333794X221141356","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-3476(85)80230-4"},{"key":"bibr6-2333794X221141356","doi-asserted-by":"publisher","DOI":"10.1542\/pir.33-5-195"},{"key":"bibr7-2333794X221141356","first-page":"2336","volume-title":"Nelson Textbook of Pediatrics","author":"DeBaun MR","year":"2016","edition":"20"},{"key":"bibr8-2333794X221141356","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-04-278747"},{"key":"bibr9-2333794X221141356","unstructured":"PORDATA. 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