{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T16:48:24Z","timestamp":1784825304562,"version":"3.55.0"},"reference-count":32,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bladder Cancer"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Neighborhood Deprivation (ND) indices serve as indicators of socioeconomic status and are recognized determinant of survival across multiple cancer types.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the potential effect of ND on urothelial bladder cancer survival outcomes using a California-specific measure, the Healthy Places Index (HPI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We queried our institutional database for patients who underwent radical cystectomy from 2013 to 2019. Patients were categorized into HPI quartiles based on their residential areas, with Q1 representing the most disadvantaged and Q4 the least disadvantaged. Multivariable logistic regression was used to identify predictors of adverse pathological features. Multivariable cox regression was utilized to evaluate the association of HPI with overall survival (OS) and recurrence free survival (RFS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 729 patients were included in our analysis. Belonging to the most disadvantaged quartile (Q1) was associated with higher odds of lymphovascular invasion (HR 1.94,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and extravesical disease (HR 1.87,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001) at presentation, compared to the least deprived quartile (Q4). Survival analyses showed that worse ND was independently associated with worse OS (Q1 vs Q4: HR: 1.76, 95% CI: 1.18\u20132.62,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.006) after adjusting for age, extravesical disease, node-positivity, and lymphovascular invasion. OS was positively associated with the education, economic, and transportation subdomains of HPI in univariable analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Greater ND is associated with adverse pathology on presentation and worse OS following radical cystectomy for UBC. Larger prospective studies are warranted to further assess the influence of social disparities on survival outcomes following RC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/23523735251406621","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T16:26:28Z","timestamp":1765297588000},"source":"Crossref","is-referenced-by-count":2,"title":["Impact of neighborhood deprivation on bladder cancer outcomes: A regional analysis"],"prefix":"10.1177","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1578-4901","authenticated-orcid":false,"given":"Anosh","family":"Dadabhoy","sequence":"first","affiliation":[{"name":"USC\/Norris Comprehensive Cancer Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0878-3559","authenticated-orcid":false,"given":"Chirag","family":"Doshi","sequence":"additional","affiliation":[{"name":"USC\/Norris Comprehensive Cancer Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6574-3919","authenticated-orcid":false,"given":"Mazyar","family":"Zahir","sequence":"additional","affiliation":[{"name":"USC\/Norris Comprehensive Cancer Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farshad","family":"Sheybaee Moghaddam","sequence":"additional","affiliation":[{"name":"USC\/Norris Comprehensive Cancer Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Santos Molina","sequence":"additional","affiliation":[{"name":"USC\/Norris Comprehensive Cancer Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sejal","family":"Mehta","sequence":"additional","affiliation":[{"name":"USC\/Norris Comprehensive Cancer Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika L","family":"Wood","sequence":"additional","affiliation":[{"name":"USC\/Norris Comprehensive Cancer Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leilei","family":"Xia","sequence":"additional","affiliation":[{"name":"USC\/Norris Comprehensive Cancer Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gus","family":"Miranda","sequence":"additional","affiliation":[{"name":"USC\/Norris Comprehensive Cancer Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Cai","sequence":"additional","affiliation":[{"name":"USC\/Norris Comprehensive Cancer Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hooman","family":"Djaladat","sequence":"additional","affiliation":[{"name":"USC\/Norris Comprehensive Cancer Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Schuckman","sequence":"additional","affiliation":[{"name":"USC\/Norris Comprehensive Cancer Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siamak","family":"Daneshmand","sequence":"additional","affiliation":[{"name":"USC\/Norris Comprehensive Cancer Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,12,9]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-008-9256-0"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-019-04435-2"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jncics\/pkad058"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.423"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23567"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s41669-024-00512-8"},{"key":"e_1_3_3_8_2","first-page":"9","article-title":"Introduction of an area deprivation Index measuring patient socioeconomic Status in an integrated health system: implications for population health","volume":"4","author":"Knighton AJ","year":"2017","unstructured":"Knighton AJ, Savitz L, Belnap T, et al. 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