{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T17:16:20Z","timestamp":1792343780042,"version":"4.4.0"},"reference-count":35,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K12CA120780"],"award-info":[{"award-number":["K12CA120780"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32-CA244125"],"award-info":[{"award-number":["T32-CA244125"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bladder Cancer"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Radical cystectomy (RC) with urinary diversion remains the standard of care for muscle invasive bladder cancer. While metabolic acidosis (MA) after RC is common, the relationship between MA, post-operative complications, and the impact of bicarbonate supplementation remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To review the role of bicarbonate therapy for MA following RC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a comprehensive systematic review according to Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines analyzing MA after RC. We included randomized controlled trials and cohort studies that reported metabolic acidosis complications and studies that utilized bicarbonate therapy peri-operatively. Our primary outcome was metabolic acidosis or role of metabolic acidosis as it relates to bicarbonate therapy or post-operative complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty-nine studies were identified to investigate MA in the setting of postoperative complication rates or the role of bicarbonate treatment in peri-operative pathways. 19 studies evaluated the incidence of MA without intervention, 5 studies supplemented bicarbonate therapy for patients meeting specific criteria, and 5 studies utilized a standardized postoperative bicarbonate therapy regimen. The incidence of post-operative metabolic acidosis ranged from 1\u201386% after continent urinary diversion and 1\u201327% after ileal conduit urinary diversion. Post-operative renal function, diabetes, and older age were factors associated with metabolic acidosis. There was lack of uniformity, indications, or consistent outcomes for utilizing postoperative bicarbonate therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There is little uniformity regarding the role of supplemental bicarbonate therapy and its impact on post-operative complications following urinary diversion. Future studies are needed to better evaluate the role MA plays in peri-operative RC pathways.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/23523735261424587","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T15:13:08Z","timestamp":1771254788000},"source":"Crossref","is-referenced-by-count":1,"title":["Systematic review: The role of bicarbonate therapy after urinary diversion"],"prefix":"10.1177","volume":"12","author":[{"given":"Shivani","family":"Desai","sequence":"first","affiliation":[{"name":"University of North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Frisbie","sequence":"additional","affiliation":[{"name":"University of North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Moreton","sequence":"additional","affiliation":[{"name":"University of North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Nielsen","sequence":"additional","affiliation":[{"name":"University of North Carolina"},{"name":"Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3500-8849","authenticated-orcid":false,"given":"Marc","family":"Bjurlin","sequence":"additional","affiliation":[{"name":"University of North Carolina"},{"name":"Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung-Jui","family":"Tan","sequence":"additional","affiliation":[{"name":"University of North Carolina"},{"name":"Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Smith","sequence":"additional","affiliation":[{"name":"University of North Carolina"},{"name":"Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0335-4467","authenticated-orcid":false,"given":"Kathryn H","family":"Gessner","sequence":"additional","affiliation":[{"name":"University of North Carolina"},{"name":"Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA"},{"name":"Department of Genetics, University of North Carolina, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,2,16]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2014.01.097"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/bju.12830"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00240-002-0257-2"},{"key":"e_1_3_3_5_2","article-title":"Risk factors for developing metabolic acidosis after radical cystectomy and ileal neobladder","volume":"11","author":"Kim KH","year":"2016","unstructured":"Kim KH, Yoon HS, Yoon H, et al. 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