{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:50:03Z","timestamp":1785307803037,"version":"3.55.0"},"reference-count":20,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Philanthropic support from Steve Loeser in Memory of Anne Loeser"},{"name":"North Carolina University Cancer Research Fund"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Patient Experience"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:p>Scientific advancements have led to more people living longer with metastatic breast cancer (MBC). Antibody-drug conjugates (ADCs) offer a promising treatment option, but currently approved ADCs are associated with significant side effects that can impact quality of life. Dose reductions may help mitigate these effects, yet little is known about real-world, patient-reported experiences with ADC dosing. We surveyed 170 individuals with MBC who had received ADC treatment to assess initial dosing, dose modifications, and barriers to supportive care. Most respondents (94.1%) began treatment with the recommended dosing frequency and 82.9% with the recommended dose. However, 35.3% reported dose reductions, primarily due to experienced or anticipated side effects. Open-ended responses underscored the burden of side effects: \u201cIf not for low dose, I don\u2019t think I could go on.\u201d Most participants (81.0%) reported oncologist-led efforts to manage side effects, and 73.0% used medications for symptom control. Financial barriers were common, with 43.5% reporting difficulty accessing supportive care. These findings highlight the need for patient-centered dosing strategies and improved access to supportive care.<\/jats:p>","DOI":"10.1177\/23743735261457837","type":"journal-article","created":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T18:04:46Z","timestamp":1780164286000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["A Patient-Led Survey of Antibody Drug Conjugate Usage and Dosing for People Living With Metastatic Breast Cancer"],"prefix":"10.1177","volume":"13","author":[{"given":"Amy","family":"Beumer","sequence":"first","affiliation":[{"name":"Patient Centered Dosing Initiative"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7994-6443","authenticated-orcid":false,"given":"Martha","family":"Carlson","sequence":"additional","affiliation":[{"name":"Patient Centered Dosing Initiative"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abby L.","family":"Arcuri","sequence":"additional","affiliation":[{"name":"Gillings School of Global Public Health, University of North Carolina at Chapel Hill"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Maues","sequence":"additional","affiliation":[{"name":"Patient Centered Dosing Initiative"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice","family":"Cowden","sequence":"additional","affiliation":[{"name":"Patient Centered Dosing Initiative"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Walker","sequence":"additional","affiliation":[{"name":"Patient Centered Dosing Initiative"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Shanahan","sequence":"additional","affiliation":[{"name":"Patient Centered Dosing Initiative"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo Lynn","family":"Collins","sequence":"additional","affiliation":[{"name":"Patient Centered Dosing Initiative"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AJ","family":"Veach","sequence":"additional","affiliation":[{"name":"Patient Centered Dosing Initiative"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hope S.","family":"Rugo","sequence":"additional","affiliation":[{"name":"City of Hope Cancer Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark E.","family":"Burkard","sequence":"additional","affiliation":[{"name":"University of Iowa Holden Comprehensive Cancer Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin M.","family":"Kalinsky","sequence":"additional","affiliation":[{"name":"Emory Winship Comprehensive Cancer Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditya","family":"Bardia","sequence":"additional","affiliation":[{"name":"University of California Los Angeles Jonsson Comprehensive Cancer Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam B.","family":"Lustberg","sequence":"additional","affiliation":[{"name":"Yale Cancer Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2771-9579","authenticated-orcid":false,"given":"Elizabeth Lerner","family":"Papautsky","sequence":"additional","affiliation":[{"name":"Biomedical and Health Information Sciences, College of Applied Health Sciences, University of Illinois Chicago"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9908-910X","authenticated-orcid":false,"given":"Mya L.","family":"Roberson","sequence":"additional","affiliation":[{"name":"Gillings School of Global Public Health, University of North Carolina at Chapel Hill"},{"name":"Lineberger Comprehensive Cancer Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,30]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djac158"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.25881"},{"issue":"12","key":"e_1_3_7_4_2","first-page":"735","article-title":"Re-imagining metastatic breast cancer care delivery: a patient-partnered qualitative study","volume":"31","author":"Roberson ML","year":"2023","unstructured":"Roberson ML, Henricks A, Woods J, et al. 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