{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T22:50:33Z","timestamp":1788821433217,"version":"build-2803163510"},"reference-count":32,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Sage Open Nursing"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Palliative care aims to enhance the quality of life (QoL) of individuals with serious or life-limiting illnesses through holistic physical, psychological, and social support. Nurses play a central role in delivering palliative care; however, the specific contribution of nurse-led interventions to improving patient outcomes remains insufficiently clarified in the literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This systematic review aimed to examine the effectiveness of nurse-led palliative care interventions in improving patient-reported quality of life among adults with advanced or life-limiting illnesses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review was conducted following the PRISMA 2020 guidelines. Six electronic databases were searched to identify empirical studies published between 2020 and 2025 that evaluated nurse-led palliative care interventions. Eligible studies included randomized controlled trials, quasi-experimental studies, and cohort designs that reported patient-reported QoL outcomes. Study selection and data extraction were performed independently by two reviewers. Due to heterogeneity in study designs, intervention characteristics, and outcome measures, the findings were synthesized using a narrative approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty studies met the inclusion criteria and represented diverse health-system contexts and clinical settings. Overall, nurse-led interventions demonstrated positive trends in several QoL domains. Improvements were frequently reported in symptom management, emotional well-being, communication quality, and family engagement. Multi-component and sustained interventions showed more consistent benefits, particularly in community and home-based care settings. Some studies also indicated reductions in healthcare utilization and improved patient\u2013family communication.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Nurse-led palliative care interventions may enhance patient-centered outcomes when implemented as comprehensive and contextually integrated care models. Further research is needed to standardize intervention definitions, evaluate long-term effectiveness, and expand evidence beyond oncology populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/23779608261447464","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T10:53:51Z","timestamp":1777287231000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Effectiveness of Nurse-Led Palliative Care Interventions on Patient Quality of Life: A Systematic Review"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2414-7982","authenticated-orcid":false,"given":"Mohammad","family":"Qtait","sequence":"first","affiliation":[{"name":"Palestine Polytechnic University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nesreen","family":"Alqaissi","sequence":"additional","affiliation":[{"name":"Palestine Polytechnic University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4959-7125","authenticated-orcid":false,"given":"Yousef","family":"Jaradat","sequence":"additional","affiliation":[{"name":"Palestine Polytechnic University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Faisal","family":"AlAli","sequence":"additional","affiliation":[{"name":"Al-Zaytoonah University of Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zenat","family":"Mesk","sequence":"additional","affiliation":[{"name":"Palestine Polytechnic University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,27]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12912-025-02959-4"},{"issue":"3","key":"e_1_3_4_3_1","first-page":"335","article-title":"Effectiveness of nurse-led hospital palliative care programs in Palestine: A quasi-experimental study","volume":"22","author":"Al-Hroub A.","year":"2024","unstructured":"Al-Hroub A., Dwaikat N., Abu-Saad H. (2024). Effectiveness of nurse-led hospital palliative care programs in Palestine: A quasi-experimental study. Palliative & Supportive Care, 22(3), 335\u2013343. https:\/\/doi.org\/10.1017\/S1478951523002112","journal-title":"Palliative & Supportive Care"},{"issue":"15","key":"e_1_3_4_4_1","first-page":"4567","article-title":"Nurse-led telehealth follow-up in chronic disease palliative care: A cohort study from Jordan","volume":"32","author":"Al-Khalidi M.","year":"2023","unstructured":"Al-Khalidi M., Abu-Saleh K., Ahmad R. (2023). Nurse-led telehealth follow-up in chronic disease palliative care: A cohort study from Jordan. Journal of Clinical Nursing, 32(15\u201316), 4567\u20134576. https:\/\/doi.org\/10.1111\/jocn.17188","journal-title":"Journal of Clinical Nursing"},{"issue":"4","key":"e_1_3_4_5_1","first-page":"455","article-title":"Nurse-led family education in neurological palliative care: A randomized controlled trial in Jordan","volume":"54","author":"Al-Qudah M.","year":"2024","unstructured":"Al-Qudah M., Hijazi R., Salem S. (2024). Nurse-led family education in neurological palliative care: A randomized controlled trial in Jordan. NeuroRehabilitation, 54(4), 455\u2013464. https:\/\/doi.org\/10.3233\/NRE-230123","journal-title":"NeuroRehabilitation"},{"issue":"8","key":"e_1_3_4_6_1","first-page":"1234","article-title":"The effectiveness of nurse-led supportive care interventions in oncology: A randomized controlled trial","volume":"25","author":"Ali N.","year":"2022","unstructured":"Ali N., Hudson P., Aranda S. (2022). The effectiveness of nurse-led supportive care interventions in oncology: A randomized controlled trial. Journal of Palliative Medicine, 25(8), 1234\u20131242. https:\/\/doi.org\/10.1089\/jpm.2022.0008","journal-title":"Journal of Palliative Medicine"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.56294\/saludcyt2025543"},{"issue":"2","key":"e_1_3_4_8_1","first-page":"567","article-title":"Nurse-led outpatient palliative care and patient quality of life: Evidence from the UAE","volume":"33","author":"Barakat H.","year":"2025","unstructured":"Barakat H., Al-Mansouri A., Rahman F. (2025). Nurse-led outpatient palliative care and patient quality of life: Evidence from the UAE. Supportive Care in Cancer, 33(2), 567\u2013578. https:\/\/doi.org\/10.1007\/s00520-025-08344-9","journal-title":"Supportive Care in Cancer"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l6890"},{"issue":"2","key":"e_1_3_4_10_1","first-page":"145","article-title":"Nurse-led enhanced supportive care as an early palliative approach: Effects on role functioning and emotional well-being","volume":"23","author":"Choi J.","year":"2025","unstructured":"Choi J., Kim S., Park Y. (2025). Nurse-led enhanced supportive care as an early palliative approach: Effects on role functioning and emotional well-being. Palliative & Supportive Care, 23(2), 145\u2013154. https:\/\/doi.org\/10.1017\/S1478951525001117","journal-title":"Palliative & Supportive Care"},{"issue":"1","key":"e_1_3_4_11_1","first-page":"115","article-title":"Nurse-led supportive counseling and quality of life among patients with chronic illness in Lebanon","volume":"22","author":"Farah N.","year":"2024","unstructured":"Farah N., Karam G., Sleiman R. (2024). Nurse-led supportive counseling and quality of life among patients with chronic illness in Lebanon. Palliative & Supportive Care, 22(1), 115\u2013124. https:\/\/doi.org\/10.1017\/S1478951523000452","journal-title":"Palliative & Supportive Care"},{"key":"e_1_3_4_12_1","first-page":"345","article-title":"Nurse-led palliative rehabilitation for COPD patients: Impact on symptom burden and quality of life","volume":"18","author":"Hassan A. M.","year":"2023","unstructured":"Hassan A. M., Elhadidy A. A., Ibrahim H. (2023). Nurse-led palliative rehabilitation for COPD patients: Impact on symptom burden and quality of life. International Journal of Chronic Obstructive Pulmonary Disease, 18, 345\u2013354. https:\/\/doi.org\/10.2147\/COPD.S385245","journal-title":"International Journal of Chronic Obstructive Pulmonary Disease"},{"issue":"2","key":"e_1_3_4_13_1","first-page":"217","article-title":"Nurse-led advance care planning and palliative interventions: A randomized trial in oncology patients","volume":"37","author":"Haun M. W.","year":"2023","unstructured":"Haun M. W., Estel S., R\u00fccker G., Villalobos M., Thomas M., Hartmann M. (2023). Nurse-led advance care planning and palliative interventions: A randomized trial in oncology patients. Palliative Medicine, 37(2), 217\u2013227. https:\/\/doi.org\/10.1177\/02692163221145578","journal-title":"Palliative Medicine"},{"issue":"2","key":"e_1_3_4_14_1","first-page":"103","article-title":"Position statement: The role of nursing in palliative and hospice care","volume":"25","author":"Health Policy Nursing Association","year":"2023","unstructured":"Health Policy Nursing Association. (2023). Position statement: The role of nursing in palliative and hospice care. Journal of Hospice & Palliative Nursing, 25(2), 103\u2013106. https:\/\/doi.org\/10.1097\/NJH.0000000000001027","journal-title":"Journal of Hospice & Palliative Nursing"},{"issue":"3","key":"e_1_3_4_15_1","first-page":"201","article-title":"Nurse-led home palliative care for renal failure patients in Palestine: A randomized controlled trial","volume":"49","author":"Jaber S.","year":"2023","unstructured":"Jaber S., Qumsieh A. (2023). Nurse-led home palliative care for renal failure patients in Palestine: A randomized controlled trial. Journal of Renal Care, 49(3), 201\u2013209. https:\/\/doi.org\/10.1111\/jorc.12457","journal-title":"Journal of Renal Care"},{"key":"e_1_3_4_16_1","first-page":"104612","article-title":"Exploring the role of nurses in palliative care: A qualitative meta-synthesis","volume":"146","author":"Kim S. Y.","year":"2024","unstructured":"Kim S. Y., Choi J., Park Y. H. (2024). Exploring the role of nurses in palliative care: A qualitative meta-synthesis. International Journal of Nursing Studies, 146, 104612. https:\/\/doi.org\/10.1016\/j.ijnurstu.2023.104612","journal-title":"International Journal of Nursing Studies"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000039817"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.202012-1494OC"},{"issue":"8","key":"e_1_3_4_19_1","first-page":"1234","article-title":"A nurse-led primary palliative care intervention and patient outcomes: A randomized controlled trial","volume":"25","author":"McCorkle R.","year":"2022","unstructured":"McCorkle R., Jeon S., Ercolano E., Schulman-Green D. (2022). A nurse-led primary palliative care intervention and patient outcomes: A randomized controlled trial. Journal of Palliative Medicine, 25(8), 1234\u20131242. https:\/\/doi.org\/10.1089\/jpm.2022.0008","journal-title":"Journal of Palliative Medicine"},{"issue":"5","key":"e_1_3_4_20_1","first-page":"2299","article-title":"Nurse-led symptom monitoring and patient-reported outcomes in oncology: A quasi-experimental study","volume":"32","author":"M\u00fcller C.","year":"2024","unstructured":"M\u00fcller C., Hentschel L., Ernst J. (2024). Nurse-led symptom monitoring and patient-reported outcomes in oncology: A quasi-experimental study. Supportive Care in Cancer, 32(5), 2299\u20132309. https:\/\/doi.org\/10.1007\/s00520-024-07845-1","journal-title":"Supportive Care in Cancer"},{"key":"e_1_3_4_21_1","first-page":"88","article-title":"Home-based nurse-led palliative care for hospice patients in Qatar: A cohort study","volume":"24","author":"Nasser R.","year":"2025","unstructured":"Nasser R., Al-Khaled M., Al-Suwaidi J. (2025). Home-based nurse-led palliative care for hospice patients in Qatar: A cohort study. BMC Palliative Care, 24, 88. https:\/\/doi.org\/10.1186\/s12904-025-01234-5","journal-title":"BMC Palliative Care"},{"key":"e_1_3_4_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_3_4_23_1","unstructured":"Popay J. Roberts H. Sowden A. Petticrew M. Arai L. Rodgers M. Britten N. Duffy S. (2006). Guidance on the conduct of narrative synthesis in systematic reviews. ESRC Methods Programme. 2006. https:\/\/www.scirp.org\/reference\/referencespapers?referenceid=1243156"},{"issue":"7","key":"e_1_3_4_24_1","first-page":"1485","article-title":"Nurse-led telehealth interventions in palliative care: A cohort study in advanced lung disease","volume":"33","author":"Qian Y.","year":"2024","unstructured":"Qian Y., Zhou Y., Fang J. (2024). Nurse-led telehealth interventions in palliative care: A cohort study in advanced lung disease. Journal of Clinical Nursing, 33(7\u20138), 1485\u20131497. https:\/\/doi.org\/10.1111\/jocn.17145","journal-title":"Journal of Clinical Nursing"},{"key":"e_1_3_4_25_1","doi-asserted-by":"publisher","DOI":"10.12968\/ijpn.2024.0060"},{"key":"e_1_3_4_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/nicc.70401"},{"issue":"2","key":"e_1_3_4_27_1","first-page":"567","article-title":"Commentary on nurse-led interventions for dyspnea in advanced lung disease: Insights and future directions","volume":"14","author":"Reinke L. F.","year":"2025","unstructured":"Reinke L. F. (2025). Commentary on nurse-led interventions for dyspnea in advanced lung disease: Insights and future directions. Annals of Palliative Medicine, 14(2), 567\u2013570. https:\/\/doi.org\/10.21037\/apm-24-547","journal-title":"Annals of Palliative Medicine"},{"issue":"5","key":"e_1_3_4_28_1","first-page":"321","article-title":"The PEACH model: Sustainability of nurse-led palliative care programs","volume":"25","author":"Rosa W. E.","year":"2023","unstructured":"Rosa W. E., Coats H., Ferrell B. R., Meghani S. H. (2023). The PEACH model: Sustainability of nurse-led palliative care programs. Journal of Hospice & Palliative Nursing, 25(5), 321\u2013329. https:\/\/doi.org\/10.1097\/NJH.0000000000001213","journal-title":"Journal of Hospice & Palliative Nursing"},{"issue":"9","key":"e_1_3_4_29_1","first-page":"7711","article-title":"Nurse-led education and counseling for oncology patients: A randomized controlled trial in Egypt","volume":"30","author":"Saleh M.","year":"2022","unstructured":"Saleh M., Hassan S., Ali F. (2022). Nurse-led education and counseling for oncology patients: A randomized controlled trial in Egypt. Supportive Care in Cancer, 30(9), 7711\u20137720. https:\/\/doi.org\/10.1007\/s00520-022-07238-1","journal-title":"Supportive Care in Cancer"},{"issue":"3","key":"e_1_3_4_30_1","first-page":"1789","article-title":"Nurse-led home-based palliative care: Effects on quality of life in advanced cancer patients","volume":"14","author":"Tang J.","year":"2025","unstructured":"Tang J., Lee H., Nguyen T. (2025). Nurse-led home-based palliative care: Effects on quality of life in advanced cancer patients. Annals of Palliative Medicine, 14(3), 1789\u20131801. https:\/\/doi.org\/10.21037\/apm-24-299","journal-title":"Annals of Palliative Medicine"},{"issue":"3","key":"e_1_3_4_31_1","first-page":"188","article-title":"Nurse-led telehealth in home-based palliative care for older adults: Outcomes on quality of life and utilization","volume":"31","author":"Thompson E.","year":"2025","unstructured":"Thompson E., Zhou L. (2025). Nurse-led telehealth in home-based palliative care for older adults: Outcomes on quality of life and utilization. Journal of Telemedicine and Telecare, 31(3), 188\u2013196. https:\/\/doi.org\/10.1177\/1357633X24528212","journal-title":"Journal of Telemedicine and Telecare"},{"issue":"8","key":"e_1_3_4_32_1","first-page":"1281","article-title":"Tele-palliative care led by nurses for advanced cancer and heart failure: A randomized trial","volume":"36","author":"White C.","year":"2022","unstructured":"White C., MacDonald R., Smith K. (2022). Tele-palliative care led by nurses for advanced cancer and heart failure: A randomized trial. Palliative Medicine, 36(8), 1281\u20131290. https:\/\/doi.org\/10.1177\/02692163221098456","journal-title":"Palliative Medicine"},{"key":"e_1_3_4_33_1","unstructured":"World Health Organization. (2022). Palliative care. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/palliative-care"}],"container-title":["Sage Open Nursing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/23779608261447464","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/23779608261447464","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/23779608261447464","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:16:56Z","timestamp":1777465016000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/23779608261447464"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":32,"alternative-id":["10.1177\/23779608261447464"],"URL":"https:\/\/doi.org\/10.1177\/23779608261447464","relation":{},"ISSN":["2377-9608","2377-9608"],"issn-type":[{"value":"2377-9608","type":"print"},{"value":"2377-9608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"article-number":"23779608261447464"}}