{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T10:53:10Z","timestamp":1777805590562,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:00:00Z","timestamp":1728432000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R03 DE028636"],"award-info":[{"award-number":["R03 DE028636"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["JDR Clinical &amp; Translational Research"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Obesity is associated with increased periodontal disease prevalence and incidence. This retrospective cohort study examined whether body mass index (BMI) is an effect modifier of periodontal treatment outcomes in patients attending an urban dental school clinic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Data were extracted from electronic health records of 344 patients at a large urban dental school clinic who had at least 1 tooth with a probing pocket depth (PD) \u22655 mm at baseline and who subsequently received nonsurgical periodontal treatment. BMI was computed from self-reported weight and height and categorized as obese (\u226530 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ), overweight (25\u201329.9 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ), or healthy (18\u201324.9 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ). The primary treatment outcome of interest was defined as having no teeth with PD \u22655 mm in a quadrant on follow-up after nonsurgical periodontal therapy. That outcome was considered to represent treatment success in this study. Secondary outcomes included changes in mean PD and clinical attachment loss (CAL). Analyses included 879 treated quadrants among 344 patients (185 males, 159 females; mean age 49 \u00b1 12 y at baseline; mean posttreatment follow-up of 6 \u00b1 2 mo). Clinical outcomes in patients who were overweight or obese were compared to healthy-weight patients using generalized linear models for binary or continuous outcomes, accounting for clustering within patients. Covariates were age, gender, tobacco use, history of diabetes, insurance type, and number of baseline sites \u22655 mm.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Obesity was associated with a significantly lower likelihood of successful nonsurgical treatment (odds ratio = 0.47; 95% confidence interval, 0.25\u20130.88) than healthy weight. Being overweight was not associated with treatment success. Posttreatment reductions in the percentage of sites with pockets \u22655 mm and CAL \u22655 mm were greater in patients with healthy weight as compared to those either overweight or obese. However, posttreatment changes in mean PD and CAL did not differ among the BMI groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Obesity adversely modifies the effectiveness of nonsurgical periodontal treatment among dental school clinic patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Knowledge Transfer Statement:<\/jats:title>\n                    <jats:p>The results of this study may be used by dental providers to better understand and manage periodontal therapy in patients with obesity. Furthermore, patients will be better informed about their therapeutic options and outcome success.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/23800844241276863","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T08:58:03Z","timestamp":1728550683000},"page":"324-332","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect Modification by Obesity on Nonsurgical Periodontal Treatment"],"prefix":"10.1177","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7529-2501","authenticated-orcid":false,"given":"E.","family":"Kaye","sequence":"first","affiliation":[{"name":"Department of Health Policy and Health Services Research, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"McDonough","sequence":"additional","affiliation":[{"name":"Department of Health Policy and Health Services Research, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Singhal","sequence":"additional","affiliation":[{"name":"Department of Community Dentistry and Behavioral Science, University of Florida College of Dentistry, Gainesville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.I.","family":"Garcia","sequence":"additional","affiliation":[{"name":"Department of Health Policy and Health Services Research, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Jurasic","sequence":"additional","affiliation":[{"name":"Department of General Dentistry, Director of the Center for Clinical Research, and Department of Health Policy and Health Services Research, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,10,9]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-016-1793-4"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.110646"},{"issue":"3","key":"e_1_3_2_4_1","first-page":"309","article-title":"Effect of periodontal treatment on serum C-reactive protein level in obese and normal-weight women affected with chronic periodontitis","volume":"33","author":"Al-Zahrani MS","year":"2012","unstructured":"Al-Zahrani MS, Alghamdi HS. 2012. Effect of periodontal treatment on serum C-reactive protein level in obese and normal-weight women affected with chronic periodontitis. Saudi Med J. 33(3):309\u2013314.","journal-title":"Saudi Med J"},{"key":"e_1_3_2_5_1","unstructured":"American Dental Association. 2021. CDT 2021: current dental terminology. 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