{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T05:14:22Z","timestamp":1778044462546,"version":"3.51.4"},"reference-count":41,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T00:00:00Z","timestamp":1747008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100008530","name":"european regional development fund","doi-asserted-by":"publisher","award":["1.1.1.2\/VIAA\/3\/19\/543, Contract No 9.-14.5\/27"],"award-info":[{"award-number":["1.1.1.2\/VIAA\/3\/19\/543, Contract No 9.-14.5\/27"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005375","name":"latvijas zin\u0101tnes padome","doi-asserted-by":"publisher","award":["No. lzp-2022\/1-0047"],"award-info":[{"award-number":["No. lzp-2022\/1-0047"]}],"id":[{"id":"10.13039\/501100005375","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Postdoc Latvia","award":["1.1.1.2\/VIAA\/3\/19\/543, contract no 9.-14.5\/27"],"award-info":[{"award-number":["1.1.1.2\/VIAA\/3\/19\/543, contract no 9.-14.5\/27"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["JDR Clinical &amp; Translational Research"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Analyze the benefit\u2013cost analysis of noninvasive early childhood caries (ECC) management in Latvian preschoolers versus placebo, from a health care perspective, over 12 mo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Randomized, blinded, placebo-controlled trial (September 2020\u2013August 2022) at Riga Stradins University, Latvia. A factorial trial was conducted with 3 interventions (placebo, silver diamine fluoride [SDF], Tiefenfluorid) and 2 recall intervals (none: 1 and 6 mo: 2), all including behavioral modification. The 6 strategies were placebo (P1, P2), SDF (SDF1, SDF2), and Tiefenfluorid (TF1, TF2). Probabilistic sensitivity analysis was calculated from the health care perspective. Costs associated with each ECC management program and associated treatments were identified and measured. Incremental benefit\u2013cost ratios (IBCRs) were calculated to determine the margin by which each program was more beneficial than P1 (comparator). The primary outcome measure used for economic evaluation was health care complications averted, defined as teeth with pulp involvement due to dental caries. The economic costs associated with health care complications averted were quantified in monetary terms as benefits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>All alternative strategies were more effective than the comparator in averting health care complications and dental caries lesions. Over 12 mo, SDF2, TF2, and P2 were dominant interventions, yielding an IBCR of \u22120.98, \u22120.80, and \u22120.70, respectively. SDF1 and TF1 had an IBCR of 2.95 and 10.67, respectively, rending these interventions economically beneficial but with lower return on investment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      Biannual SDF applications (SDF2) were the most cost-effective for ECC, significantly outperforming Tiefenfluorid\n                      <jats:sup>\u00ae<\/jats:sup>\n                      (TF2) and placebo (P2). TF2 and P2 slightly improved over placebo (P1) due to additional behavioral modification and counseling. Implementing SDF2 in Latvia would likely reduce health care complications and costs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Knowledge Transfer Statement:<\/jats:title>\n                    <jats:p>This study compared 5 noninvasive early childhood caries management strategies with a placebo \u201cno treatment\u201d group over a 12-mo period. The primary outcome measure was health care complications averted, quantified in monetary terms. The results showed that the 6-monthly applications of SDF and fluoride varnish demonstrated cost savings compared with the placebo group. The study recommends implementing SDF and fluoride varnish into routine clinical practice to reduce health care complications and associated costs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/23800844251332888","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T07:43:27Z","timestamp":1747035807000},"page":"195-203","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Benefit\u2013Cost Analysis of Noninvasive Early Childhood Caries Interventions among Latvian Children"],"prefix":"10.1177","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5967-956X","authenticated-orcid":false,"given":"I.","family":"Maldupa","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry and Oral Health, Riga Stradins University, Riga, Latvia"},{"name":"Riga Stradins University Institute of Stomatology, Ltd"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0684-2025","authenticated-orcid":false,"given":"S.E.","family":"Uribe","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Oral Health, Riga Stradins University, Riga, Latvia"},{"name":"Baltic Biomaterials Centre of Excellence, Headquarters at Riga Technical University, Riga, Latvia"},{"name":"Department of Conservative Dentistry and Periodontology, LMU University Hospital, LMU Munich, Germany"},{"name":"Riga Stradins University Institute of Stomatology, Ltd"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8723-5464","authenticated-orcid":false,"given":"O.","family":"S\u013cepcova","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Oral Health, Riga Stradins University, Riga, Latvia"},{"name":"Riga Stradins University Institute of Stomatology, Ltd"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6422-9061","authenticated-orcid":false,"given":"E.","family":"Senakola","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Oral Health, Riga Stradins University, Riga, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1843-0423","authenticated-orcid":false,"given":"A.","family":"Brinkmane","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Oral Health, Riga Stradins University, Riga, Latvia"},{"name":"Riga Stradins University Institute of Stomatology, Ltd"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9986-7629","authenticated-orcid":false,"given":"T.M.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Deakin Health Economics, School of Health and Social Development, Institute for Health Transformation Deakin University, Burwood, VIC, Australia"},{"name":"Health Economics Group School of Public Health and Prevention Medicine, Medicine, Nursing and Health Sciences, Monash University, Melbourne, VIC, Australia"},{"name":"Dental Health Services Victora, Carlton, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9984-0012","authenticated-orcid":false,"given":"N.","family":"Innes","sequence":"additional","affiliation":[{"name":"School of Dentistry, College of Biomedical and Life Sciences, Cardiff University, Cardiff, Wales, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3061-843X","authenticated-orcid":false,"given":"R.","family":"Mari\u00f1o","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Oral Health, Riga Stradins University, Riga, Latvia"},{"name":"Center for Research in Epidemiology, Economics and Oral Public Health (CIEESPO), University de La Frontera, Temuco, Chile"},{"name":"University of Melbourne, Melbourne, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,5,12]]},"reference":[{"key":"e_1_3_2_2_1","unstructured":"American Academy of Pediatric Dentistry. 2024. 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