{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:35:35Z","timestamp":1792064135169,"version":"4.4.0"},"reference-count":40,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100004368","name":"colgate-palmolive company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004368","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["JDR Clinical &amp; Translational Research"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Dental caries remains a significant oral health burden globally. Scientific evidence has demonstrated the dose-dependent anticaries action of fluoride; however, more effective, comprehensive, and alternative prevention strategies are required.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A 2-y, phase 3, randomized controlled trial based on a double-blind, 3-arm, parallel-group design was conducted from April 15, 2019, through March 12, 2022 across 3 centers in China. Six thousand children aged 10 to 14 y with \u22652 active caries lesions were assigned 1 of 3 study dentifrices: 8.0% arginine, 1.5% arginine, and 0.32% sodium fluoride (NaF). The primary efficacy outcomes were incremental DMFS (decayed, missing, and filled surfaces) and DMFT (decayed, missing, and filled teeth) caries indices scores after 2 y of product use. The secondary efficacy outcomes were the incremental caries indices scores after 1 y and 6 mo of product use. Noninferiority was achieved if the 95% CI of the mean difference in scores was below the noninferiority margin of 0.2545 after 2 y, 1 y, and 6 mo of product use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>After 2 y, the 8.0% arginine\u2013containing dentifrice demonstrated a statistically significant reduction of 26.0% in DMFS scores (\u22120.16; 95% CI, \u22120.22 to \u22120.10; P &lt; .001) and 25.3% in DMFT scores (\u22120.17; 95% CI, \u22120.24 to \u22120.11; P &lt; .001) versus control. No statistical difference was measured between the 1.5% arginine\u2013containing dentifrice and control in DMFS (\u22120.01; 95% CI, \u22120.07 to 0.05; P = .819) and DMFT (\u22120.01; 95% CI, \u22120.07 to 0.05; P = .739).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Dentifrice containing 8.0% arginine showed a statistically significant reduction in caries incidence versus the NaF control, while the 1.5% arginine dentifrice showed equivalence to the NaF control regarding caries reduction. This clinical study confirms that arginine dentifrices are effective alternatives to fluoride in providing anticaries protection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Knowledge Transfer Statement:<\/jats:title>\n                    <jats:p>This study demonstrates that arginine is an efficacious anticaries agent at the examined doses of 1.5% and 8%. Clinicians and consumers can consider this a new caries preventive agent providing choice to people seeking fluoride-free alternatives. Policy makers could leverage these findings to guide oral health initiatives and inform regulations on dentifrice composition, promoting broader access to effective caries prevention methods.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/23800844251361471","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T17:01:33Z","timestamp":1755018093000},"page":"204-214","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Arginine Dentifrices and Childhood Caries Prevention: A Randomized Clinical Trial"],"prefix":"10.1177","volume":"11","author":[{"given":"W.","family":"Yin","sequence":"first","affiliation":[{"name":"Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Zhou","sequence":"additional","affiliation":[{"name":"Chongqing Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.-Z.","family":"Huang","sequence":"additional","affiliation":[{"name":"Xi\u2019an Jiaotong University, Xi\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Sun","sequence":"additional","affiliation":[{"name":"Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Zhong","sequence":"additional","affiliation":[{"name":"Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Yang","sequence":"additional","affiliation":[{"name":"Chongqing Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Li","sequence":"additional","affiliation":[{"name":"Chongqing Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Xi\u2019an Jiaotong University, Xi\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Xi\u2019an Jiaotong University, Xi\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Hu","sequence":"additional","affiliation":[{"name":"Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.R.","family":"Mateo","sequence":"additional","affiliation":[{"name":"LRM Statistical Consulting (Mateo), West Orange, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Gao","sequence":"additional","affiliation":[{"name":"Rutherfoord Consulting, Stirling, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Lim","sequence":"additional","affiliation":[{"name":"Kornberg School of Dentistry, Temple University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.I.","family":"Ismail","sequence":"additional","affiliation":[{"name":"Kornberg School of Dentistry, Temple University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Zimmerman","sequence":"additional","affiliation":[{"name":"Colgate-Palmolive Company, Piscataway, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2224-2174","authenticated-orcid":false,"given":"B.","family":"Garcia-Godoy","sequence":"additional","affiliation":[{"name":"Colgate-Palmolive Company, Piscataway, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ryan","sequence":"additional","affiliation":[{"name":"Colgate-Palmolive Company, Piscataway, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.-P.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Colgate-Palmolive Company, Piscataway, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,8,12]]},"reference":[{"issue":"3","key":"e_1_3_3_2_1","first-page":"63","article-title":"The inhibitory effect of an arginine bicarbonate\/calcium carbonate CaviStat-containing dentifrice on the development of dental caries in Venezuelan school children","volume":"16","author":"Acevedo AM","year":"2005","unstructured":"Acevedo AM, Machado C, Rivera LE, Wolff M, Kleinberg I. 2005. 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