{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T04:34:57Z","timestamp":1777264497816,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100013414","name":"Conseil R\u00e9gional des Pays de la Loire","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013414","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-20-COV8-0002-01"],"award-info":[{"award-number":["ANR-20-COV8-0002-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-22-CE36-0009-01"],"award-info":[{"award-number":["ANR-22-CE36-0009-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["MDM Policy &amp; Practice"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    <jats:bold>Background.<\/jats:bold>\n                    Because of the COVID-19 pandemic, we realize that kidney transplantation (KT) suspension may become necessary. Although the impact of KT moratoriums on the mortality of candidates for KT has been reported, health-related quality of life (HRQoL) was usually not considered. For crisis preparedness, we aimed to include quality-adjusted life-years (QALYs) in the balance.\n                    <jats:bold>Methods.<\/jats:bold>\n                    We estimated 1) the health-state evolution of the French end-stage renal disease population using a semi-Markovian approach (76,980 French patients who began dialysis or were registered on the waitlist for KT between 2011 and 2019), 2) the post-KT evolution of HRQoL using a linear mixed-effects model (4,819 EQ-5D questionnaires from 2,835 French KT recipients), and 3) the HRQoL conversion for dialyzed patients according to Li\u2019s model.\n                    <jats:bold>Results.<\/jats:bold>\n                    For patients registered on the active waitlist at the beginning of the moratorium, we predicted a loss of 0.96 life-months in perfect health for a 7-mo moratorium (95% confidence interval [0.11, 1.78]). This loss was smaller for patients who become active candidates after a moratorium decision. Regardless, we reported higher losses of QALYs for patients younger than 60 y than for older patients, for every considered moratorium duration.\n                    <jats:bold>Conclusions.<\/jats:bold>\n                    KT moratoriums can be sustainable regarding both quantity and quality of life, provided they do not exceed a prolonged period. In case of future crisis with a long reduction of KT activity, we reported that priority may be proposed to the younger patients.\n                  <\/jats:p>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:list list-type=\"bullet\">\n                      <jats:list-item>\n                        <jats:p>Our results provide arguments supporting the decision of suspending kidney transplantation activity in case of future crises, provided that the moratorium duration does not exceed a few months.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>We report that patients active on the waitlist at the beginning of the moratorium lose the most quality-adjusted life-years due to the suspension, particularly candidates younger than 60\u2009y. Hence, if another crisis occurs with the possibility of maintaining only small kidney transplantation activity, giving priority to younger patients active on the list may be justified.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Considering quality-adjusted life-years rather than raw survival time results in a more complete assessment of the effect of suspending kidney transplantation in patients with end-stage renal disease by taking their quality of life into account.<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:sec>","DOI":"10.1177\/23814683261440974","type":"journal-article","created":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T04:24:36Z","timestamp":1777091076000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Crisis Preparedness by Simulating Quality-Adjusted Life-Year Loss in Patients with End-Stage Renal Disease due to Kidney Transplantation Suspensions"],"prefix":"10.1177","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1654-2253","authenticated-orcid":false,"given":"Vincent","family":"Bonnemains","sequence":"first","affiliation":[{"name":"INSERM UMR 1246 - SPHERE, Universit\u00e9 de Nantes, Universit\u00e9 de Tours, Nantes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florent","family":"Le Borgne","sequence":"additional","affiliation":[{"name":"Data Factory &amp; Analytics Department, Institut de Canc\u00e9rologie de l'Ouest, F-44805 Nantes-Angers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Etienne","family":"Dantan","sequence":"additional","affiliation":[{"name":"INSERM UMR 1246 - SPHERE, Universit\u00e9 de Nantes, Universit\u00e9 de Tours, Nantes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myriam","family":"Pastural","sequence":"additional","affiliation":[{"name":"Agence de la biom\u00e9decine, Saint-Denis La Plaine, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magali","family":"Giral","sequence":"additional","affiliation":[{"name":"CRTI UMR 1064, INSERM, Universit\u00e9 de Nantes; ITUN, Centre Hospitalier Universitaire de Nantes; Nantes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9cile","family":"Couchoud","sequence":"additional","affiliation":[{"name":"Agence de la biom\u00e9decine, Saint-Denis La Plaine, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohann","family":"Foucher","sequence":"additional","affiliation":[{"name":"INSERM, CIC-1402, Centre Hospitalier Universitaire de Poitiers, Universit\u00e9 de Poitiers, Poitiers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfaa261"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(21)00200-0"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16117"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000004369"},{"key":"e_1_3_3_6_2","article-title":"Panic in the pandemic: when should kidney transplant programs close?","volume":"6","author":"Vinson AJ","year":"2021","unstructured":"Vinson AJ, Kiberd BA, Tennankore KK. Panic in the pandemic: when should kidney transplant programs close? Kidney Int Rep. 2021;6:1232\u201341.","journal-title":"Kidney Int Rep"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16190"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2020.03.022"},{"key":"e_1_3_3_9_2","volume-title":"Transplantation","volume":"101","author":"Tong A","year":"2017","unstructured":"Tong A, Gill J, Budde K, et al. Toward establishing core outcome domains for trials in kidney transplantation: report of the standardized outcomes in nephrology-kidney transplantation consensus workshops. 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