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Xanthine oxidase inhibition for improvement of long-term outcomes following ischaemic stroke and transient ischaemic attack (XILO-FIST) aims to assess the effect of allopurinol treatment on white matter hyperintensity progression and blood pressure after stroke. This paper describes the XILO-FIST protocol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>XILO-FIST is a multicentre randomised double-blind, placebo-controlled, parallel group clinical trial funded by the British Heart Foundation and the Stroke Association. The trial has been adopted by the Scottish Stroke Research Network and the UK Clinical Research Network. The trial is registered in clinicaltrials.gov (registration number NCT02122718). XILO-FIST will randomise 464 participants, aged greater than 50 years, with ischaemic stroke within the past month, on a 1:1 basis, to two years treatment with allopurinol 300 mg twice daily or placebo. Participants will undergo brain magnetic resonance imaging, cognitive assessment, ambulatory blood pressure monitoring and blood sampling at baseline and after two years treatment. The primary outcome will be white matter hyperintensity progression, measured using the Rotterdam progression scale. Secondary outcomes will include change in white matter hyperintensity volume, mean day-time systolic blood pressure and measures of cognitive function. Up to 100 will undergo additional cardiac magnetic resonance imaging in a sub-study of left ventricular mass.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>If white matter hyperintensity progression is reduced, allopurinol could be an effective preventative treatment for patients with ischaemic stroke and clinical endpoint studies would be needed. If allopurinol reduces blood pressure after stroke, then it could be used to help patients reach blood pressure targets.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2396987318771426","type":"journal-article","created":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T08:22:07Z","timestamp":1524039727000},"page":"281-290","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":29,"title":["Xanthine oxidase inhibition for the improvement of long-term outcomes following ischaemic stroke and transient ischaemic attack (XILO-FIST) \u2013 Protocol for a randomised double blind placebo-controlled clinical trial"],"prefix":"10.1093","volume":"3","author":[{"given":"Jesse","family":"Dawson","sequence":"first","affiliation":[{"name":"Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary & Life Sciences, Queen Elizabeth University Hospital, University of Glasgow, Glasgow, UK 1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niall","family":"Broomfield","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary & Life Sciences, Queen Elizabeth University Hospital, University of Glasgow, Glasgow, UK 1"},{"name":"Stroke Psychology, West Glasgow Ambulatory Care Hospital, Scotland, UK 2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishna","family":"Dani","sequence":"additional","affiliation":[{"name":"Department of Neurology, Institute of Neurological Sciences Glasgow, Queen Elizabeth University Hospital, Glasgow, UK 3"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A","family":"Dickie","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary & Life Sciences, Queen Elizabeth University Hospital, University of Glasgow, Glasgow, UK 1"},{"name":"DD Analytics Cubed Ltd, Bishopton, UK 4"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Doney","sequence":"additional","affiliation":[{"name":"Medicine Monitoring Unit (MEMO), School of Medicine, University of Dundee. 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