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We investigated whether long-term mortality, recurrent stroke and MI risks differ in people with versus without lacunar\/SVD ischaemic stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>We included first-ever strokes from a hospital-based stroke cohort study recruited in 2002\u20132005. We compared risks of death, recurrent stroke and MI during follow-up among lacunar\/SVD versus other ischaemic stroke subtypes using Cox regression, adjusting for confounding factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 812 participants, 283 with lacunar\/SVD ischaemic stroke and 529 with other stroke. During a median of 9.2\u00a0years (interquartile range 3.1\u201311.8), there were 519 deaths, 181 recurrent strokes and 79 MIs. Lacunar\/SVD stroke was associated with lower mortality (adjusted HR 0.79, 95% CI 0.65 to 0.95), largely due to markedly lower all-cause mortality in the first year. From one year onwards this difference attenuated, with all-cause mortality only slightly and not statistically significantly lower in the lacunar\/SVD group (0.86, 95% CI 0.70 to 1.05). There was no clear difference in risk of recurrent stroke (HR 0.84, 95% CI 0.61\u20131.15) or MI (HR 0.83, 95% CI 0.52\u20131.34).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Long-term risks of all-cause mortality, recurrent stroke and MI are similar, or only slightly lower, in patients with lacunar\/SVD as compared to other ischaemic stroke. Patients and physicians should be as vigilant in optimising short- and long-term secondary prevention of vascular events in lacunar\/SVD as for other stroke types.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/23969873211062019","type":"journal-article","created":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T02:43:25Z","timestamp":1640918605000},"page":"57-65","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Long-term mortality and recurrent vascular events in lacunar versus non-lacunar ischaemic stroke: A cohort study"],"prefix":"10.1093","volume":"7","author":[{"given":"Suzanne","family":"Portegijs","sequence":"first","affiliation":[{"name":"Usher Institute, University of Edinburgh, Edinburgh, Scotland 1"},{"name":"Vrije Universiteit Amsterdam, Amsterdam, the Netherlands 2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariel 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