{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T11:02:51Z","timestamp":1769079771255,"version":"3.49.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T00:00:00Z","timestamp":1765584000000},"content-version":"vor","delay-in-days":1291,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["10430012010014"],"award-info":[{"award-number":["10430012010014"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002996","name":"Hartstichting","doi-asserted-by":"publisher","award":["10430012010014"],"award-info":[{"award-number":["10430012010014"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["10430012010014"],"award-info":[{"award-number":["10430012010014"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002996","name":"Hartstichting","doi-asserted-by":"publisher","award":["10430012010014"],"award-info":[{"award-number":["10430012010014"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,6,1]]},"abstract":"<jats:title>\u2003<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>COVID-19 is often complicated by thrombo-embolic events including ischemic stroke. The underlying mechanisms of COVID-19-associated ischemic stroke, the incidence and risk factors of silent cerebral ischemia, and the long-term functional outcome in these patients are currently unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods:<\/jats:title>\n                    <jats:p>CORONavirus and Ischemic Stroke (CORONIS) is a multicentre prospective cohort study investigating the prevalence, risk factors and long-term incidence of (silent) cerebral ischemia, and the long-term functional outcome among patients with COVID-19. We aim to include 200 adult patients hospitalized with COVID-19 without symptomatic ischemic stroke to investigate the prevalence of silent cerebral ischemia compared with 60 (matched) controls with MRI. In addition, we will identify potential risk factors and\/or causes of cerebral ischemia in COVID-19 patients with (n\u2009=\u200970) or without symptomatic stroke (n\u2009=\u2009200) by means of blood sampling, cardiac workup and brain MRI. We will measure functional outcome and cognitive function after 3 and 12\u2009months with standardized questionnaires in all patients with COVID-19. Finally, the long-term incidence of (new) silent cerebral ischemia in patients with COVID-19 will be assessed with follow up MRI (n\u2009=\u2009120).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Summary:<\/jats:title>\n                    <jats:p>The CORONIS study is designed to add further insight into the prevalence, long-term incidence and risk factors of cerebral ischemia, and the long-term functional outcome in hospitalized adult patients with COVID-19.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/23969873221092538","type":"journal-article","created":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T02:05:36Z","timestamp":1649297136000},"page":"180-187","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Prevalence, risk factors, and long-term outcomes of cerebral ischemia in hospitalized COVID-19 patients \u2013 study rationale and protocol of the CORONIS study: A multicentre prospective cohort study"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2814-8368","authenticated-orcid":false,"given":"Theresa J","family":"van Lith","sequence":"first","affiliation":[{"name":"Department of Neurology, Donders Center for Medical Neuroscience, Radboud University Medical Center, Nijmegen, The Netherlands 1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wouter M","family":"Sluis","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, Brain Center, University Medical Center Utrecht, Utrecht, The Netherlands 2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi T","family":"Wijers","sequence":"additional","affiliation":[{"name":"Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands 3"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5921-639X","authenticated-orcid":false,"given":"Frederick JA","family":"Meijer","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands 4"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Kamphuis-van Ulzen","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands 4"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeroen","family":"de Bresser","sequence":"additional","affiliation":[{"name":"Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands 5"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan Willem","family":"Dankbaar","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, University Medical Center, Utrecht University, Utrecht, The Netherlands 6"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederik MA","family":"van den Heuvel","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands 7"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M Louisa","family":"Antoni","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart and Lung Centre, Leiden University Medical Centre, Leiden, The Netherlands 8"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catharina M","family":"Mulders-Manders","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherland 9"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quirijn","family":"de Mast","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands 10"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank L","family":"van de Veerdonk","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands 10"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9961-0754","authenticated-orcid":false,"given":"Frederikus A","family":"Klok","sequence":"additional","affiliation":[{"name":"Department of Medicine \u2013 Thrombosis and Hemostasis, Leiden University Medical Centre, Leiden, The Netherlands 11"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anil M","family":"Tuladhar","sequence":"additional","affiliation":[{"name":"Department of Neurology, Donders Center for Medical Neuroscience, Radboud University Medical Center, Nijmegen, The Netherlands 1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne C","family":"Cannegieter","sequence":"additional","affiliation":[{"name":"Department of Medicine \u2013 Thrombosis and Hemostasis, Leiden University Medical Centre, Leiden, The Netherlands 11"},{"name":"Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands 12"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marieke JH","family":"Wermer","sequence":"additional","affiliation":[{"name":"Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands 3"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9891-2136","authenticated-orcid":false,"given":"H Bart","family":"van der Worp","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, Brain Center, University Medical Center Utrecht, Utrecht, The Netherlands 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