{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T04:11:47Z","timestamp":1769141507267,"version":"3.49.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T00:00:00Z","timestamp":1765584000000},"content-version":"vor","delay-in-days":1018,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Previous medical history strongly contributes to the genesis of intracranial aneurysms (IA). A possible impact of regular medication on the occurrence of abdominal aortic aneurysms has been reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>To evaluate the value of regular medication on the risk of development and rupture of IA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Data on medication use and related comorbidities were obtained from the institutional IA registry. A 1:1 age- and sex-matched patient sample was collected from the population-based Heinz Nixdorf Recall Study with individuals from the same area.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In the analysis comparing IA cohort (n\u2009=\u20091960) with the matched normal population (n\u2009=\u20091960), the use of statins (adjusted odds ratio, 1.34 [95% confidence interval 1.02\u20131.78]), antidiabetics (1.46 [1.08\u20131.99]), and calcium channel blockers (1.49 [1.11\u20132.00]) was independently associated with higher risk of IA, whereas uricostatics (0.23 [0.14\u20130.38]), aspirin (0.23 [0.13\u20130.43]), beta-blockers (0.51 [0.40\u20130.66]), and angiotensin-converting enzyme inhibitors (0.38 [0.27\u20130.53]) were related to lower risk of IA. In the multivariable analysis within the IA cohort (n\u2009=\u20092446), SAH patients showed higher drug exposure with thiazide diuretics (2.11 [1.59\u20132.80]), but lower prevalence of remaining antihypertensive medication\u2014beta-blockers (0.38 [0.30\u20130.48]), calcium channel blockers (0.63 [0.48\u20130.83]), angiotensin-converting enzyme inhibitors (0.56 [0.44\u20130.72]), and angiotensin-1 receptor blockers (0.33 [0.24\u20130.45]). Patients with ruptured IA were less likely to be treated with statins (0.62 [0.47\u20130.81]), thyroid hormones (0.62 [0.48\u20130.79]), and aspirin (0.55 [0.41\u20130.75]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Regular medication might impact the risks related to the development and rupture of IA. Further clinical trials are required to clarify the effect of regular medication on IA genesis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/23969873221129080","type":"journal-article","created":{"date-parts":[[2022,10,8]],"date-time":"2022-10-08T02:40:42Z","timestamp":1665196842000},"page":"251-258","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Regular medication as a risk factor for intracranial aneurysms: A comparative case\u2013control study"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8356-6629","authenticated-orcid":false,"given":"Ramazan","family":"Jabbarli","sequence":"first","affiliation":[{"name":"Department of Neurosurgery and Spine Surgery, University Hospital Essen, Essen, Germany 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