{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:29:48Z","timestamp":1793039388441,"version":"4.5.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T00:00:00Z","timestamp":1765584000000},"content-version":"vor","delay-in-days":1018,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Endovascular thrombectomy (EVT) increases the chance of good functional outcome after ischemic stroke caused by a large vessel occlusion, but the risk of death in the first 90\u2009days is still considerable. We assessed the causes, timing and risk factors of death after EVT to aid future studies aiming to reduce mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods:<\/jats:title>\n                    <jats:p>We used data from the MR CLEAN Registry, a prospective, multicenter, observational cohort study of patients treated with EVT in the Netherlands between March 2014, and November 2017. We assessed causes and timing of death and risk factors for death in the first 90\u2009days after treatment. Causes and timing of death were determined by reviewing serious adverse event forms, discharge letters, or other written clinical information. Risk factors for death were determined with multivariable logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of 3180 patients treated with EVT, 863 (27.1%) died in the first 90\u2009days. The most common causes of death were pneumonia (215 patients, 26.2%), intracranial hemorrhage (142 patients, 17.3%), withdrawal of life-sustaining treatment because of the initial stroke (110 patients, 13.4%) and space-occupying edema (101 patients, 12.3%). In total, 448 patients (52% of all deaths) died in the first week, with intracranial hemorrhage as most frequent cause. The strongest risk factors for death were hyperglycemia and functional dependency before the stroke and severe neurological deficit at 24\u201348\u2009h after treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion and conclusion:<\/jats:title>\n                    <jats:p>When EVT fails to decrease the initial neurological deficit, strategies to prevent complications like pneumonia and intracranial hemorrhage after EVT could improve survival, as these are often the cause of death.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/23969873221143210","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T05:12:18Z","timestamp":1670994738000},"page":"215-223","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Timing and causes of death after endovascular thrombectomy in patients with acute ischemic stroke"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3057-2010","authenticated-orcid":false,"given":"Wouter M","family":"Sluis","sequence":"first","affiliation":[{"name":"Department of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wouter H","family":"Hinsenveld","sequence":"additional","affiliation":[{"name":"Department of Neurology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert-Jan B","family":"Goldhoorn","sequence":"additional","affiliation":[{"name":"Department of Neurology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianne H","family":"Potters","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnetha AE","family":"Bruggeman","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anouk","family":"van der Hoorn","sequence":"additional","affiliation":[{"name":"Department of Radiology, Medical Imaging Center (MIC), University Medical Center Groningen, Groningen, The Netherlands 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph CJ","family":"Bot","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Location VUmc, Amsterdam, The Netherlands 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J","family":"van Oostenbrugge","sequence":"additional","affiliation":[{"name":"Department of Neurology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hester F","family":"Lingsma","sequence":"additional","affiliation":[{"name":"Public Health Department, Erasmus MC University Medical Center, Rotterdam, The Netherlands 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeannette","family":"Hofmeijer","sequence":"additional","affiliation":[{"name":"Department of Neurology, Rijnstate Hospital, Arnhem, and Department of Clinical Neurophysiology, University of Twente, Enschede, The Netherlands 7"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1631-7056","authenticated-orcid":false,"given":"Wim H","family":"van Zwam","sequence":"additional","affiliation":[{"name":"Department of Radiology, Maastricht University Medical Center, Maastricht, The Netherlands 8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"BLM Majoie","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9891-2136","authenticated-orcid":false,"given":"H","family":"Bart van der Worp","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the MR CLEAN Registry Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,3,1]]},"reference":[{"key":"2026012113112934900_bibr1-23969873221143210","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1056\/NEJMoa1414905","article-title":"Randomized assessment of rapid endovascular treatment of ischemic stroke","volume":"372","author":"Goyal","year":"2015","journal-title":"N Engl J Med"},{"key":"2026012113112934900_bibr2-23969873221143210","doi-asserted-by":"crossref","first-page":"e014425","DOI":"10.1161\/JAHA.119.014425","article-title":"Mortality risk in acute ischemic stroke patients with large vessel occlusion treated with mechanical thrombectomy","volume":"8","author":"Katsanos","year":"2019","journal-title":"J Am Heart 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