{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T12:31:09Z","timestamp":1772109069434,"version":"3.50.1"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Hydrocephalus after aneurysmal subarachnoid haemorrhage (aSAH) is a common complication which may lead to insertion of a ventriculoperitoneal shunt (VPS). Our aim is to evaluate a possible influence of specific clinical and biochemical factors on VPS dependency with special emphasis on hyperglycaemia on admission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods:<\/jats:title>\n                    <jats:p>Retrospective analysis of a monocentric database of aSAH patients. Using univariable and multivariable logistic regression analysis we evaluated factors influencing VPS dependency, with a special focus on hyperglycaemia on blood sample within 24\u2009h of admission, dichotomised at 126\u2009mg\/dl. Factors evaluated in the univariable analysis were age, sex, known diabetes, Hunt and Hess grade, Barrow Neurological Institute scale, treatment modality, extra-ventricular drain (EVD) insertion, complications (rebleeding, vasospasm, infarction, decompressive craniectomy, ventriculitis), outcome variables and laboratory parameters (glucose, C-reactive protein, procalcitonin).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We included 510 consecutive patients treated with acute aSAH requiring a VPS (mean age 58.2\u2009years, 66% were female). An EVD was inserted in 387 (75.9%) patients. In the univariable analysis, VPS dependency was associated with hyperglycaemia on admission (OR 2.56, 95%CI 1.58\u20134.14, p\u2009&amp;lt;\u20090.001). In the multivariable regression analysis after stepwise backward regression, factors associated with VPS dependency were hyperglycaemia &amp;gt;126\u2009mg\/dl on admission (OR 1.93, 95%CI 1.13\u20133.30, p\u2009=\u20090.02), ventriculitis (OR 2.33, 95%CI 1.33\u20134.04, p\u2009=\u20090.003), Hunt and Hess grade (overall p-value 0.02) and decompressive craniectomy (OR 2.68, 95%CI 1.55\u20134.64, p\u2009&amp;lt;\u20090.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Hyperglycaemia on admission was associated with an increased probability of VPS placement. If confirmed, this finding might facilitate treatment of these patients by accelerating insertion of a permanent draining system.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/23969873221147087","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T02:16:42Z","timestamp":1672280202000},"page":"301-308","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["VPS dependency after aneurysmal subarachnoid haemorrhage and influence of admission hyperglycaemia"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9004-2540","authenticated-orcid":false,"given":"Isabel Charlotte","family":"Hostettler","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany 1"},{"name":"Department of Neurosurgery, Cantonal Hospital St. Gallen, St. Gallen, Switzerland 2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Lange","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany 1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Schwendinger","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany 1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gareth","family":"Ambler","sequence":"additional","affiliation":[{"name":"Department of Statistical Science, University College London, London, UK 3"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8662-8891","authenticated-orcid":false,"given":"Theresa","family":"Hirle","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany 1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samira","family":"Frangoulis","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany 1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4042-2999","authenticated-orcid":false,"given":"Dominik","family":"Trost","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany 4"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Gempt","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany 1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kornelia","family":"Kreiser","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany 4"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany 1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christof","family":"Winter","sequence":"additional","affiliation":[{"name":"Institute of Clinical Chemistry and Pathobiochemistry, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany 5"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Wostrack","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany 1"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,3,1]]},"reference":[{"key":"2026012113113783300_bibr1-23969873221147087","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1159\/000346087","article-title":"European Stroke Organization. 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