{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T03:57:44Z","timestamp":1784779064544,"version":"3.55.0"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T00:00:00Z","timestamp":1673568000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100004362","name":"Schweizerische Herzstiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004362","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Stroke Journal"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>There is little data on the safety and efficacy of endovascular treatment (EVT) in comparison with intravenous thrombolysis (IVT) in acute ischemic stroke due to isolated posterior cerebral artery occlusion (IPCAO). We aimed to investigate the functional and safety outcomes of stroke patients with acute IPCAO treated with EVT (with or without prior bridging IVT) compared to IVT alone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We did a multicenter retrospective analysis of data from the Swiss Stroke Registry. The primary endpoint was overall functional outcome at 3\u2009months in patients undergoing EVT alone or as part of bridging, compared with IVT alone (shift analysis). Safety endpoints were mortality and symptomatic intracranial hemorrhage. EVT and IVT patients were matched 1:1 using propensity scores. Differences in outcomes were examined using ordinal and logistic regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings:<\/jats:title>\n                    <jats:p>\n                      Out of 17,968 patients, 268 met the inclusion criteria and 136 were matched by propensity scores. The overall functional outcome at 3\u2009months was comparable between the two groups (EVT vs IVT as reference category: OR\u2009=\u20091.42 for higher mRS, 95% CI\u2009=\u20090.78\u20132.57,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.254). The proportion of patients independent at 3\u2009months was 63.2% in EVT and 72.1% in IVT (OR\u2009=\u20090.67, 95% CI\u2009=\u20090.32\u20131.37,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.272). Symptomatic intracranial hemorrhages were overall rare and present only in the IVT group (IVT\u2009=\u20095.9% vs EVT\u2009=\u20090%). Mortality at 3\u2009months was also similar between the two groups (IVT\u2009=\u20090% vs EVT\u2009=\u20091.5%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In this multicenter nested analysis, EVT and IVT in patients with acute ischemic stroke due to IPCAO were associated with similar overall good functional outcome and safety. Randomized studies are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/23969873221150125","type":"journal-article","created":{"date-parts":[[2023,1,14]],"date-time":"2023-01-14T01:39:50Z","timestamp":1673660390000},"page":"575-580","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":29,"title":["Endovascular therapy outcome in isolated posterior cerebral artery occlusion strokes: A multicenter analysis of the Swiss Stroke Registry"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0295-0571","authenticated-orcid":false,"given":"F","family":"Maulucci","sequence":"first","affiliation":[{"name":"Stroke Centre, Neurology Department, Neurocentre of Southern Switzerland, EOC, Lugano, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Disanto","sequence":"additional","affiliation":[{"name":"Stroke Centre, Neurology Department, Neurocentre of Southern Switzerland, EOC, Lugano, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Bianco","sequence":"additional","affiliation":[{"name":"Stroke Centre, Neurology Department, Neurocentre of Southern Switzerland, EOC, Lugano, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Pileggi","sequence":"additional","affiliation":[{"name":"Stroke Centre, Interventional and Diagnostic Neuroradiology, Neurocentre of Southern Switzerland, EOC, Lugano, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0521-4051","authenticated-orcid":false,"given":"U","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Bern, Bern, Switzerland"},{"name":"Department of Neurology and Stroke Centre, University Hospital Basel, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Padlina","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Bern, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Strambo","sequence":"additional","affiliation":[{"name":"Lausanne University Hospital, Stroke Centre, Neurology Service, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Michel","sequence":"additional","affiliation":[{"name":"Lausanne University Hospital, Stroke Centre, Neurology Service, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1569-6376","authenticated-orcid":false,"given":"T","family":"Kahles","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kantonsspital Aarau, Aarau, 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Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JB","family":"Escribano Paredes","sequence":"additional","affiliation":[{"name":"Department of Neurology, H\u00f4pitaux Universitaires de Gen\u00e8ve, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Carrera","sequence":"additional","affiliation":[{"name":"Department of Neurology, H\u00f4pitaux Universitaires de Gen\u00e8ve, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Nyffeler","sequence":"additional","affiliation":[{"name":"Luzerner Kantonsspital, Centre of Neurology and Neurorehabilitation, Luzern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Bolognese","sequence":"additional","affiliation":[{"name":"Luzerner Kantonsspital, Centre of Neurology and Neurorehabilitation, Luzern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4369-7023","authenticated-orcid":false,"given":"S","family":"Wegener","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsspital Z\u00fcrich, Neurology, Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Luft","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsspital Z\u00fcrich, Neurology, Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Schelosky","sequence":"additional","affiliation":[{"name":"Kantonsspital M\u00fcnsterlingen, Division of Neurology, M\u00fcnsterlingen, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Medlin","sequence":"additional","affiliation":[{"name":"Stroke Unit, Division of Neurology, HFR Fribourg, Fribourg, 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