{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T14:01:23Z","timestamp":1783951283909,"version":"3.55.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,3,18]],"date-time":"2023-03-18T00:00:00Z","timestamp":1679097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100007131","name":"Changzhou Sci&Tech Program","doi-asserted-by":"publisher","award":["CJ20210084 and CJ20220093"],"award-info":[{"award-number":["CJ20210084 and CJ20220093"]}],"id":[{"id":"10.13039\/501100007131","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Young Talent Development Plan of Changzhou Health Commission","award":["CZQM2022001"],"award-info":[{"award-number":["CZQM2022001"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Stroke Journal"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background and purpose:<\/jats:title>\n                    <jats:p>To evaluate the association of genetic liability to migraine with functional outcome after ischemic stroke using Mendelian randomization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Genetic proxies for migraine were obtained from the largest genome-wide association study meta-analysis of 102,084 migraine cases and 771,257 controls. Genetic associations with functional outcome after ischemic stroke were obtained from the Genetics of Ischemic Stroke Functional Outcome network study (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u20096021). Poor functional outcome after ischemic stroke was defined as a score of 3\u20136 on the modified Rankin scale at 3\u2009months (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u20092280). The inverse-variance weighted method was used to estimate the association of genetic liability to migraine with functional outcome, and we performed sensitivity analyses to assess the robustness of results.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Genetic liability to migraine was associated with poor functional outcome after ischemic stroke (odds ratio of poor functional outcome per doubling in migraine odds 1.22, 95% confidence interval 1.02\u20131.45,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.031). This association remained directionally consistent across sensitivity analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This study provides genetic support that migraine is associated with poor functional outcome after ischemic stroke. These findings warrant further follow-up and, if replicated, may have clinical implications for post-stroke recovery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/23969873231164728","type":"journal-article","created":{"date-parts":[[2023,3,18]],"date-time":"2023-03-18T08:07:01Z","timestamp":1679126821000},"page":"517-521","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Genetic liability to migraine and functional outcome after ischemic stroke"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9890-8900","authenticated-orcid":false,"given":"Mengmeng","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurology, The Third Affiliated Hospital of Soochow University, Changzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iyas","family":"Daghlas","sequence":"additional","affiliation":[{"name":"Department of 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