{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T10:33:19Z","timestamp":1775644399938,"version":"3.50.1"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Taiwan National Science and Technology Council","award":["NSTC 111-2628-B-002-044"],"award-info":[{"award-number":["NSTC 111-2628-B-002-044"]}]},{"name":"Taiwan National Science and Technology Council","award":["NSTC-112-2923-B-002-001-MY3"],"award-info":[{"award-number":["NSTC-112-2923-B-002-001-MY3"]}]},{"name":"Taiwan National Science and Technology Council","award":["NSTC 111-2628-B-002-044"],"award-info":[{"award-number":["NSTC 111-2628-B-002-044"]}]},{"name":"Taiwan National Science and Technology Council","award":["NSTC-112-2923-B-002-001-MY3"],"award-info":[{"award-number":["NSTC-112-2923-B-002-001-MY3"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Acute blood pressure (BP) reduction is the first-line treatment for acute spontaneous intracerebral hemorrhage (ICH); however, recent research suggests that intensive BP reduction along with cerebral small vessel disease (cSVD) is a risk factor for remote DWI lesions (RDWILs). We aimed to delineate the interplay between cSVD and BP reduction therapy on the risk of RDWILs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We enrolled 303 patients who underwent brain magnetic resonance imaging within 7\u2009days after acute spontaneous ICH. RDWILs were categorized as occurring in borderzone (BZ) or non-BZ areas. We examined the effect of cSVD, acute BP reduction, and their interaction on RDWILs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>RDWILs were observed in 34 (11%) patients (59.8\u2009\u00b1\u200910.3-years-old, 24% male). RDWILs were associated with a larger acute weighted average mean arterial pressure (MAP) reduction in the initial 24\u2009h after ICH onset and a higher total cerebral microbleed (CMB) count. Intensive MAP changes (odds ratio (OR) per 10\u2009mmHg 1.76, 95% confidence interval (CI) 1.03\u20133.20), total CMBs burden (OR per 10 CMBs 1.21, 95% CI 1.08\u20131.39), and presence of lobar CMBs (OR 7.33, 95% CI 1.59\u201355.6) were risk factors for RDWILs at BZ, but not at non-BZ. Furthermore, a significant interaction was observed between lobar CMBs and MAP reduction on increased risk of RDWILs at BZ (p\u2009=\u20090.030).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>cSVD modulates the effect of acute BP reduction on the risk of RDWILs. Patients with extensive microangiopathy have a higher risk of developing cerebral ischemic changes in BZ during unstable hemodynamic status.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/23969873231170989","type":"journal-article","created":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T01:13:57Z","timestamp":1682039637000},"page":"828-835","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Interaction between cerebral small vessel disease, blood pressure, and remote ischemic lesions in acute spontaneous intracerebral hemorrhage"],"prefix":"10.1093","volume":"8","author":[{"given":"Szu-Ju","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Neurology, National Taiwan University Hospital Bei-Hu Branch, Taipei 1"},{"name":"Department of Neurology, National Taiwan University Hospital, Taipei 2"},{"name":"Graduate Institute of Clinical Medicine, National Taiwan University 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