{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T13:38:54Z","timestamp":1771594734661,"version":"3.50.1"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["POCI-01-0145-FEDER-031674 (PTDC\/MEC-NEU\/31674\/2017"],"award-info":[{"award-number":["POCI-01-0145-FEDER-031674 (PTDC\/MEC-NEU\/31674\/2017"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["POCI-01-0145-FEDER-031674 (PTDC\/MEC-NEU\/31674\/2017"],"award-info":[{"award-number":["POCI-01-0145-FEDER-031674 (PTDC\/MEC-NEU\/31674\/2017"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To determine the cancer incidence after the first-ever cerebrovascular event (CVE) and compare it to the cancer incidence in the population from the same region.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We evaluated 1069 patients with a first-ever CVE (Ischaemic or haemorrhagic stroke and Transient Ischaemic Attack) from a prospective population registry of stroke and transient focal neurological attacks, diagnosed between 2009 and 2011. We conducted a structured search to identify cancer-related variables and case-fatality for a period of 8\u2009years following CVE. Cancer incidence in CVE patients was compared to the North Region Cancer Registry (RORENO).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We found that 90\/1069 (8.4%) CVE patients developed cancer after a first-ever CVE. Overall cancer annual incidence rate was higher after a CVE (820\/100,000, 95%CI: 619\u20131020) than in general population (513\/100,000, 95%CI: 508\u2013518). In the 45\u201354 age group cancer incidence post-CVE was 3.2-fold (RR, 95%CI: 1.6\u20136.4) higher compared to the general population, decreasing gradually in older age-groups. Median time between CVE and cancer was 3.2\u2009years (IQR\u2009=\u20091.4\u20135.2). Lower respiratory tract and colorectal were the most frequent cancer types. In univariable models, male sex (sHR\u2009=\u20091.78, 95%CI: 1.17\u20132.72, p\u2009=\u20090.007), tobacco use (sHR\u2009=\u20092.04, 95%CI: 1.31\u20133.18, p\u2009=\u20090.002) and peripheral artery disease (sHR\u2009=\u20092.37, 95%CI: 1.10\u20135.13, p\u2009=\u20090.028) were associated to higher cancer risk after CVE. After adjustment, tobacco use (sHR\u2009=\u20091.84, 95%CI: 1.08\u20133.14, p\u2009=\u20090.026) remained associated to a higher risk of cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>At the population level, patients presenting a first-ever CVE have higher cancer incidence, that is particularly prominent in younger age-groups. Higher cancer incidence, delayed cancer diagnosis and increased mortality post-CVE warrants further research on long-term cancer surveillance in first-ever CVE survivors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/23969873231181628","type":"journal-article","created":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T03:00:15Z","timestamp":1686798015000},"page":"792-801","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["The crosstalk between Stroke and Cancer: Incidence of cancer after a first-ever cerebrovascular event in a population-based study"],"prefix":"10.1093","volume":"8","author":[{"given":"Catarina Guedes","family":"Vaz","sequence":"first","affiliation":[{"name":"Servi\u00e7o de Neurologia, Hospital Santo Ant\u00f3nio \u2013 Centro Hospitalar Universit\u00e1rio de Santo Ant\u00f3nio (HSA-CHUdSA), Porto, Portugal 1"},{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar \u2013 Universidade do Porto (ICBAS-UP), Porto, Portugal 2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9ssica","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Grupo de Epidemiologia do Cancro, Centro de Investiga\u00e7\u00e3o do Instituto Portugu\u00eas de Oncologia do Porto, Instituto Portugu\u00eas de Oncologia do Porto, Porto, Portugal 3"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diogo","family":"Pereira","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Neurologia, Hospital Santo Ant\u00f3nio \u2013 Centro Hospitalar Universit\u00e1rio de Santo Ant\u00f3nio (HSA-CHUdSA), Porto, Portugal 1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilda","family":"Matos","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Neurologia, Unidade Local de Sa\u00fade do Nordeste \u2013 Mirandela, Mirandela, Portugal 4"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Oliveira","sequence":"additional","affiliation":[{"name":"i3S \u2013 Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, Porto, Portugal 5"},{"name":"Ipatimup \u2013 Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal 6"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Jos\u00e9","family":"Bento","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar \u2013 Universidade do Porto (ICBAS-UP), Porto, Portugal 2"},{"name":"Grupo de Epidemiologia do Cancro, Centro de Investiga\u00e7\u00e3o do Instituto Portugu\u00eas de Oncologia do Porto, Instituto Portugu\u00eas de Oncologia do Porto, Porto, Portugal 3"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar \u2013 Universidade do Porto (ICBAS-UP), Porto, Portugal 2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Correia","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Neurologia, Hospital Santo Ant\u00f3nio \u2013 Centro Hospitalar Universit\u00e1rio de Santo Ant\u00f3nio (HSA-CHUdSA), Porto, Portugal 1"},{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar \u2013 Universidade do Porto (ICBAS-UP), Porto, Portugal 2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8140-3471","authenticated-orcid":false,"given":"Luis F","family":"Maia","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Neurologia, Hospital Santo Ant\u00f3nio \u2013 Centro Hospitalar Universit\u00e1rio de Santo Ant\u00f3nio (HSA-CHUdSA), Porto, Portugal 1"},{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar \u2013 Universidade do Porto (ICBAS-UP), Porto, Portugal 2"},{"name":"i3S \u2013 Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, Porto, Portugal 5"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,9,1]]},"reference":[{"key":"2026012113094696900_bibr1-23969873231181628","unstructured":"World Health Organization. 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