{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T02:46:43Z","timestamp":1788922003731,"version":"build-2803163510"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:00:00Z","timestamp":1761177600000},"content-version":"vor","delay-in-days":692,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Restricted retinal diffusion (RDR) has recently been recognized as a frequent finding on standard diffusion-weighted imaging (DWI) in central retinal artery occlusion (CRAO). However, data on early DWI signal evolution are missing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods:<\/jats:title>\n                    <jats:p>Consecutive CRAO patients with DWI performed within 24\u2009h after onset of visual impairment were included in a bicentric, retrospective cross-sectional study. Two blinded neuroradiologists assessed randomized DWI scans for the presence of retinal ischemia. RDR detection rates, false positive ratings, and interrater agreement were evaluated for predefined time groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Sixty eight CRAO patients (68.4\u2009\u00b1\u200916.8\u2009years; 25 female) with 72 DWI scans (76.4% 3\u2009T, 23.6% 1.5\u2009T) were included. Mean time-delay between onset of CRAO and DWI acquisition was 13.4\u2009\u00b1\u20097.0\u2009h. Overall RDR detection rates ranged from 52.8% to 62.5% with false positive ratings in 4.2%\u20138.3% of cases. RDR detection rates were higher in DWI performed 12\u201324\u2009h after onset, when compared with DWI acquired within the first 12\u2009h (79.5%vs 39.3%, p\u2009&amp;lt;\u20090.001). The share of false positive ratings was highest for DWI performed within the first 6\u2009h of symptom onset (up to 14.3%). Interrater reliability was \u201cmoderate\u201d for DWI performed within the first 18\u2009h (\u03ba\u2009=\u20090.57\u20130.58), but improved for DWI acquired between 18 and 24\u2009h (\u03ba\u2009=\u20090.94).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>DWI-based detection of retinal ischemia in early CRAO is likely to be time-dependent with superior diagnostic accuracy for DWI performed 12\u201324\u2009h after onset of visual impairment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/23969873231190716","type":"journal-article","created":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T00:54:05Z","timestamp":1690937645000},"page":"974-981","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Diffusion-weighted magnetic resonance imaging in early central retinal artery 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