{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:03:27Z","timestamp":1792800207683,"version":"4.5.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 81400979 and 81870931"],"award-info":[{"award-number":["No. 81400979 and 81870931"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"SanHang Program of the Naval Medical University"},{"name":"Climbing\u2019 program of Changhai Hospital","id":[{"id":"https:\/\/ror.org\/02bjs0p66","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 81400979 and 81870931"],"award-info":[{"award-number":["No. 81400979 and 81870931"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"SanHang Program of the Naval Medical University"},{"name":"Climbing\u2019 program of Changhai Hospital","id":[{"id":"https:\/\/ror.org\/02bjs0p66","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Observational studies suggest that different classes of antihypertensive drugs may have different effects on the occurrence of intracranial aneurysms (IA) and subarachnoid hemorrhage (SAH). However, the reported results in previous studies are inconsistent, and randomized data are absent. We performed a two-sample Mendelian randomization (MR) analysis to study the causal effects of genetically determined blood pressure (BP) and genetic proxies for antihypertensive drug classes on the risk of IA and SAH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods:<\/jats:title>\n                    <jats:p>Genetic instruments and outcome data were obtained from independent genome-wide association studies (GWAS) or published data, which were exclusively restricted to European ancestry. Causal relationships were identified using inverse-variance weighted MR analyses and a series of statistical sensitivity analyses. The FinnGen consortium was used for repeated analysis to verify results obtained from the above GWAS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Two-sample MR analysis showed that genetically determined Systolic BP, Dystolic BP, and Pulse Pressure were related to a higher risk of IA and SAH. Based on identified single nucleotide polymorphisms (SNPs) that influence the effect of calcium channel blockers (CCB, 42 SNPs), beta-blockers (BB, 8 SNPs), angiotensin-converting enzyme inhibitors (ACEI, 2 SNPs), angiotensin receptor blockers (ARB, 1 SNPs), and thiazides (5 SNPs), genetically determined effect of CCBs was associated with a higher risk of IA (OR, 1.07 [95% CI, 1.03\u20131.10], p\u2009=\u20095.02\u2009\u00d7\u200910\u22125) and SAH (OR, 1.06 [95% CI, 1.03\u20131.09], p\u2009=\u20091.84\u2009\u00d7\u200910\u22123). No associations were found between other antihypertensive drugs and the risk of IA or SAH. The effect of CCBs on SAH was confirmed in FinnGenconsortium samples (OR, 1.04 [95% CI, 1.00\u20131.08], p\u2009=\u20090.042).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion and conclusion:<\/jats:title>\n                    <jats:p>This MR analysis supports the role of elevated blood pressure in the occurrence of intracranial aneurysms and subarachnoid hemorrhage. However, genetic proxies for calcium channel blockers were associated with an increased risk of intracranial aneurysms and subarachnoid hemorrhage. Further studies are required to confirm these findings and investigate the underlying mechanisms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/23969873231204420","type":"journal-article","created":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T08:35:13Z","timestamp":1696581313000},"page":"244-250","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Genetically determined blood pressure, antihypertensive medications, and risk of intracranial aneurysms and aneurysmal subarachnoid hemorrhage: A Mendelian randomization study"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3533-6521","authenticated-orcid":false,"given":"Hanchen","family":"Liu","sequence":"first","affiliation":[{"name":"Neurovascular Center, Naval Medical University Changhai Hospital, Shanghai, China 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqin","family":"Zuo","sequence":"additional","affiliation":[{"name":"Huamu Community Center of Pudong, Shanghai, China 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ospel","family":"Johanna","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Hospital Basel, Basel, Switzerland 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Neurovascular Center, Naval Medical University Changhai Hospital, Shanghai, China 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Yang","sequence":"additional","affiliation":[{"name":"Neurovascular Center, Naval Medical University Changhai Hospital, Shanghai, China 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixing","family":"Chen","sequence":"additional","affiliation":[{"name":"Luoping People\u2019s Hospital, Yun\u2019nan, China 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Li","sequence":"additional","affiliation":[{"name":"Neurovascular Center, Naval Medical University Changhai Hospital, Shanghai, China 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolei","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Data Science, Fudan University, Shanghai, China 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Neurovascular Center, Naval Medical University Changhai Hospital, Shanghai, China 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianmin","family":"Liu","sequence":"additional","affiliation":[{"name":"Neurovascular Center, Naval Medical University Changhai Hospital, Shanghai, China 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