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Patients with known cardiac or arterial embolic sources were excluded. Lacunes, microbleeds, white matter hyperintensities and enlarged perivascular spaces at baseline were assessed in a brain MRI and included in a cSVD score. A follow-up MRI was obtained 2\u2009years later and assessed for the appearance of new lacunes or microbleeds. We constructed both unadjusted and adjusted models, and subsequently selected the optimal models based on the area under the curve (AUC) of the predicted probabilities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Ninety-two patients (mean age 67.04\u2009years, 69.6% men) were evaluated and 25 had new lacunes or microbleeds during follow-up. There was a strong correlation between 24-h PWV and age (r\u2009=\u20090.942, p\u2009&amp;lt;\u20090.001). cSVD was associated with new lacunes or microbleeds when adjusted by age, 24-h PWV, NT-proBNP and hypercholesterolemia (OR 2.453, CI95% 1.381\u20134.358). The models exhibiting the highest discrimination, as indicated by their area under the curve (AUC) values, were as follows: 1 (AUC 0.854) \u2013 Age, cSVD score, 24-h PWV, Hypercholesterolemia; 2 (AUC 0.852) \u2013 cSVD score, 24-h PWV, Hypercholesterolemia; and 3 (AUC 0.843) \u2013 Age, cSVD score, Hypercholesterolemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>cSVD score is a stronger predictor for cSVD progression than age or hemodynamic parameters in patients with a RSSI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/23969873231207764","type":"journal-article","created":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T06:52:41Z","timestamp":1698130361000},"page":"251-258","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Relationship of arterial stiffness and baseline vascular burden with new lacunes and microbleeds: A longitudinal cohort study"],"prefix":"10.1093","volume":"9","author":[{"given":"Luis","family":"Mena","sequence":"first","affiliation":[{"name":"Neurology Department, Complex Hospitalari Universitari Mois\u00e8s Broggi, Sant Joan Desp\u00ed, Spain 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Jos\u00e9","family":"Mengual","sequence":"additional","affiliation":[{"name":"Neurology Department, Complex Hospitalari Universitari Mois\u00e8s Broggi, Sant Joan Desp\u00ed, Spain 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia Mar\u00eda","family":"Garc\u00eda-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Neurology Department, Complex Hospitalari Universitari Mois\u00e8s Broggi, Sant Joan Desp\u00ed, Spain 1"},{"name":"Bellvitge Biomedical Research Institute (IDIBELL), L\u2019Hospitalet de Llobregat, Spain 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4851-1224","authenticated-orcid":false,"given":"Carla","family":"Avellaneda-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Neurology Department, Complex Hospitalari Universitari Mois\u00e8s Broggi, Sant Joan Desp\u00ed, Spain 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria \u00c0ngels","family":"Font","sequence":"additional","affiliation":[{"name":"Neurology Department, Complex Hospitalari Universitari Mois\u00e8s Broggi, Sant Joan Desp\u00ed, Spain 1"},{"name":"Bellvitge Biomedical Research Institute (IDIBELL), L\u2019Hospitalet de Llobregat, Spain 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Montull","sequence":"additional","affiliation":[{"name":"Bellvitge Biomedical Research Institute (IDIBELL), L\u2019Hospitalet de Llobregat, Spain 2"},{"name":"Radiology Department, Complex Hospitalari Universitari Mois\u00e8s Broggi, Sant Joan Desp\u00ed, Spain 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Castrillo","sequence":"additional","affiliation":[{"name":"Bellvitge Biomedical Research Institute (IDIBELL), L\u2019Hospitalet de Llobregat, Spain 2"},{"name":"Radiology Department, Complex Hospitalari Universitari Mois\u00e8s Broggi, Sant Joan Desp\u00ed, Spain 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Blanch","sequence":"additional","affiliation":[{"name":"Bellvitge Biomedical Research Institute (IDIBELL), L\u2019Hospitalet de Llobregat, Spain 2"},{"name":"Cardiology Department, Complex Hospitalari Universitari Mois\u00e8s Broggi, Sant Joan Desp\u00ed, Spain 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pere","family":"Castellanos","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Complex Hospitalari Universitari Mois\u00e8s Broggi, Sant Joan Desp\u00ed, Spain 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