{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T07:13:23Z","timestamp":1788246803959,"version":"build-2803163510"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T00:00:00Z","timestamp":1765584000000},"content-version":"vor","delay-in-days":652,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2018-02527"],"award-info":[{"award-number":["2018-02527"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2019-00193"],"award-info":[{"award-number":["2019-00193"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005754","name":"Sahlgrenska Universitetssjukhuset","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005754","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","award":["2021-0345,"],"award-info":[{"award-number":["2021-0345,"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","award":["2021-0702"],"award-info":[{"award-number":["2021-0702"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007212","name":"V\u00e4stra G\u00f6talandsregionen","doi-asserted-by":"publisher","award":["ALFGBG-966211"],"award-info":[{"award-number":["ALFGBG-966211"]}],"id":[{"id":"10.13039\/100007212","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2018-02527"],"award-info":[{"award-number":["2018-02527"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2019-00193"],"award-info":[{"award-number":["2019-00193"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005754","name":"Sahlgrenska Universitetssjukhuset","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005754","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","award":["2021-0345,"],"award-info":[{"award-number":["2021-0345,"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","award":["2021-0702"],"award-info":[{"award-number":["2021-0702"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007212","name":"V\u00e4stra G\u00f6talandsregionen","doi-asserted-by":"publisher","award":["ALFGBG-966211"],"award-info":[{"award-number":["ALFGBG-966211"]}],"id":[{"id":"10.13039\/100007212","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Long-term risk-factor control and secondary prevention are not well characterized in patients with a first transient ischemic attack (TIA). With baseline levels as reference, we compared primary-care data on blood pressure (BP), low-density lipoprotein cholesterol (LDL-C), smoking, and use of antihypertensives, statins and antiplatelet treatment\/oral anticoagulation (APT\/OAC) during 5\u2009years after a first TIA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods:<\/jats:title>\n                    <jats:p>Patients in QregPV, a Swedish primary-care register for the Region of V\u00e4stra G\u00f6taland, with a first TIA discharge diagnosis from wards proficient in stroke care 2010 to 2012 were identified and followed up to 5\u2009years. BP, LDL-C, smoking, use of antihypertensives, statins, APT\/OAC, and achievement of target levels were calculated. We used logistic mixed-effect models to analyze the effect of follow-up over time on risk-factor control and secondary prevention treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We identified 942 patients without prior cerebrovascular disease who had a first TIA. Compared to baseline, the first year of follow-up was associated with improvements in concomitant attainment of BP &amp;lt;140\/90\u2009mmHg, LDL-C\u2009&amp;lt;\u20092.6\u2009mmol\/L and non-smoking, which rose from 20% to 33% (OR 2.08, 95% CI 1.38\u20133.13), but then stagnated in years 2\u20135. In the first year of follow-up, 47% of patients had complete secondary prevention treatment (antihypertensives, APT\/OAC and statin), but continued follow-up was associated with a yearly decrease in secondary prevention treatment (OR 0.94, 95% CI 0.94\u20130.98).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Risk-factor control was inadequate, leaving considerable potential for improved secondary prevention treatment after a first TIA in Swedish patients followed up to 5\u2009years.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/23969873231215629","type":"journal-article","created":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T07:09:48Z","timestamp":1701328188000},"page":"154-161","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Long-term risk-factor control and secondary prevention are insufficient after first TIA: Results from QregPV"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7771-7216","authenticated-orcid":false,"given":"Johan-Emil","family":"Bager","sequence":"first","affiliation":[{"name":"Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden 1"},{"name":"Department of Emergency Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina","family":"Jood","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience, Institute of Neurosciences and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden 3"},{"name":"Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Nordanstig","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience, Institute of Neurosciences and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1419-8460","authenticated-orcid":false,"given":"Tobias","family":"Andersson","sequence":"additional","affiliation":[{"name":"Primary Health Care, School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden 5"},{"name":"Regionh\u00e4lsan R&D Centre, Skaraborg Primary Care, Sk\u00f6vde, Sweden 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonatan","family":"N\u00e5tman","sequence":"additional","affiliation":[{"name":"Centre of Registers V\u00e4stra G\u00f6taland, Gothenburg, Sweden 7"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Hjerpe","sequence":"additional","affiliation":[{"name":"Primary Health Care, School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden 5"},{"name":"Regionh\u00e4lsan R&D Centre, Skaraborg Primary Care, Sk\u00f6vde, Sweden 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Rosengren","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden 1"},{"name":"Sahlgrenska University Hospital\/\u00d6stra, Gothenburg, Sweden 8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Mourtzinis","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden 1"},{"name":"Department of Medicine and Emergency M\u00f6lndal, Sahlgrenska University Hospital, Gothenburg, Sweden 9"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,3,1]]},"reference":[{"key":"2026012113095482000_bibr1-23969873231215629","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1056\/NEJMc1808913","article-title":"Five-year risk of stroke after TIA or minor ischemic stroke","volume":"379","author":"Amarenco","year":"2018","journal-title":"N Engl J Med"},{"key":"2026012113095482000_bibr2-23969873231215629","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1212\/WNL.0000000000012781","article-title":"Global Epidemiology of stroke and access to acute ischemic stroke interventions","volume":"97","author":"Saini","year":"2021","journal-title":"Neurology"},{"key":"2026012113095482000_bibr3-23969873231215629","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1177\/2396987319883160","article-title":"Economic burden of stroke across Europe: a population-based cost analysis","volume":"5","author":"Luengo-Fernandez","year":"2020","journal-title":"Eur Stroke J"},{"key":"2026012113095482000_bibr4-23969873231215629","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/S1474-4422(16)30073-4","article-title":"Global burden of stroke and risk factors in 188 countries, during 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013","volume":"15","author":"Feigin","year":"2016","journal-title":"Lancet Neurol"},{"key":"2026012113095482000_bibr5-23969873231215629","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/S0140-6736(16)30506-2","article-title":"Global and regional effects of potentially modifiable risk factors associated with acute stroke in 32 countries (INTERSTROKE): a case-control study","volume":"388","author":"O'Donnell","year":"2016","journal-title":"Lancet"},{"key":"2026012113095482000_bibr6-23969873231215629","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1161\/STR.0000000000000024","article-title":"Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline for healthcare professionals from the American Heart Association\/American Stroke Association","volume":"45","author":"Kernan","year":"2014","journal-title":"Stroke"},{"key":"2026012113095482000_bibr7-23969873231215629","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1161\/STROKEAHA.106.475525","article-title":"Combining multiple approaches for the secondary prevention of vascular events after stroke: a quantitative modeling study","volume":"38","author":"Hackam","year":"2007","journal-title":"Stroke"},{"key":"2026012113095482000_bibr8-23969873231215629","article-title":"Yearly report from Riksstroke","volume-title":"The Swedish Stroke Register","author":"Norrving","year":"2020"},{"key":"2026012113095482000_bibr9-23969873231215629","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/s12875-020-01211-z","article-title":"Blood pressure control in patients with a previous stroke\/transient ischaemic attack in primary care in Ireland: a cross sectional study","volume":"21","author":"Doogue","year":"2020","journal-title":"BMC Fam Pract"},{"key":"2026012113095482000_bibr10-23969873231215629","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1161\/01.STR.0000017877.62543.14","article-title":"How well are hypertension, hyperlipidemia, diabetes, and smoking managed after a stroke or transient ischemic attack?","volume":"33","author":"Mouradian","year":"2002","journal-title":"Stroke"},{"key":"2026012113095482000_bibr11-23969873231215629","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12883-017-0796-3","article-title":"Management, prognosis and predictors of unfavourable outcomes in patients newly hospitalized for transient ischemic attack: a real-world investigation from Italy","volume":"17","author":"Corrao","year":"2017","journal-title":"BMC Neurol"},{"key":"2026012113095482000_bibr12-23969873231215629","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1093\/eurjpc\/zwab087","article-title":"Trends in blood pressure, blood lipids, and smoking from 259 753 patients with hypertension in a Swedish primary care register: results from QregPV","volume":"29","author":"Bager","year":"2022","journal-title":"Eur J Prev Cardiol"},{"key":"2026012113095482000_bibr13-23969873231215629","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.1600-0404.2010.01402.x","article-title":"Validation of the Swedish inpatient and cause-of-death registers in the context of stroke","volume":"123","author":"Appelros","year":"2011","journal-title":"Acta Neurol Scand"},{"key":"2026012113095482000_bibr14-23969873231215629","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1159\/000437266","article-title":"Validation of diagnoses of transient ischemic attack in the Swedish Stroke Register (Riksstroke) TIA-Module","volume":"45","author":"Buchwald","year":"2015","journal-title":"Neuroepidemiology"},{"key":"2026012113095482000_bibr15-23969873231215629","first-page":"1073","article-title":"Navigating the wild west of medication adherence reporting in specialty pharmacy","volume":"25","author":"Canfield","year":"2019","journal-title":"J Manag Care Spec Pharm"},{"key":"2026012113095482000_bibr16-23969873231215629","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1093\/eurheartj\/eht151","article-title":"2013 ESH\/ESC guidelines for the management of arterial hypertension: the Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)","volume":"34","author":"Mancia","year":"2013","journal-title":"Eur Heart J"},{"key":"2026012113095482000_bibr17-23969873231215629","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1093\/eurheartj\/ehs092","article-title":"European guidelines on cardiovascular disease prevention in clinical practice (version 2012). The Fifth Joint Task Force of the European Society of Cardiology and other societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts)","volume":"33","author":"Perk","year":"2012","journal-title":"Eur Heart J"},{"key":"2026012113095482000_bibr18-23969873231215629","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.amjhyper.2005.08.016","article-title":"Effect of terminal digit preference on blood pressure measurement and treatment in primary care","volume":"19","author":"Nietert","year":"2006","journal-title":"Am J Hypertens"},{"key":"2026012113095482000_bibr19-23969873231215629","volume-title":"R: A language and environment for statistical computing","author":"R Core Team","year":"2020"},{"key":"2026012113095482000_bibr20-23969873231215629","volume-title":"RStudio: Integrated Development for R","author":"RStudio Team","year":"2021"},{"key":"2026012113095482000_bibr21-23969873231215629","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1001\/jama.2016.7050","article-title":"Intensive vs standard blood pressure control and cardiovascular disease outcomes in adults aged \u2a7e75 years","volume":"315","author":"Williamson","year":"2016","journal-title":"JAMA"},{"key":"2026012113095482000_bibr22-23969873231215629","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1177\/2396987320975724","article-title":"Prescription of blood pressure lowering treatment after intracerebral haemorrhage: Prospective, population-based cohort study","volume":"6","author":"Bonello","year":"2021","journal-title":"Eur Stroke J"},{"key":"2026012113095482000_bibr23-23969873231215629","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1186\/s12875-018-0872-9","article-title":"Stroke follow-up in primary care: a prospective cohort study on guideline adherence","volume":"19","author":"Pedersen","year":"2018","journal-title":"BMC Fam Pract"},{"key":"2026012113095482000_bibr24-23969873231215629","doi-asserted-by":"crossref","DOI":"10.3399\/bjgp15X687373","article-title":"Gps' perspectives on secondary cardiovascular prevention in older age: a focus group study in the Netherlands","volume":"65","author":"van Peet","year":"2015","journal-title":"Br J Gen Pract"}],"container-title":["European Stroke Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/23969873231215629","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/23969873231215629","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/esj\/article-pdf\/9\/1\/154\/64653295\/23969873231215629.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/esj\/article-pdf\/9\/1\/154\/64653295\/23969873231215629.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T18:10:54Z","timestamp":1769019054000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/esj\/article\/9\/1\/154\/8269022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,1]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,3,1]]}},"URL":"https:\/\/doi.org\/10.1177\/23969873231215629","relation":{},"ISSN":["2396-9873","2396-9881"],"issn-type":[{"value":"2396-9873","type":"print"},{"value":"2396-9881","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,3,1]]},"published":{"date-parts":[[2024,3,1]]}}}