{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:38:41Z","timestamp":1791941921476,"version":"4.3.4"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000098","name":"NIH Clinical Center","doi-asserted-by":"publisher","award":["K23NS118056"],"award-info":[{"award-number":["K23NS118056"]}],"id":[{"id":"10.13039\/100000098","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000862","name":"Doris Duke Charitable Foundation","doi-asserted-by":"publisher","award":["2020097"],"award-info":[{"award-number":["2020097"]}],"id":[{"id":"10.13039\/100000862","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000098","name":"NIH Clinical Center","doi-asserted-by":"publisher","award":["K23NS118056"],"award-info":[{"award-number":["K23NS118056"]}],"id":[{"id":"10.13039\/100000098","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000862","name":"Doris Duke Charitable Foundation","doi-asserted-by":"publisher","award":["2020097"],"award-info":[{"award-number":["2020097"]}],"id":[{"id":"10.13039\/100000862","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Perihematomal edema (PHE) represents secondary brain injury and a potential treatment target in intracerebral hemorrhage (ICH). However, studies differ on optimal PHE volume metrics as prognostic factor(s) after spontaneous, non-traumatic ICH. This study examines associations of baseline and 24-h PHE shape features with 3-month outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods:<\/jats:title>\n                    <jats:p>We included 796 patients from a multicentric trial dataset and manually segmented ICH and PHE on baseline and follow-up CTs, extracting 14 shape features. We explored the association of baseline, follow-up, difference (baseline\/follow-up) and temporal rate (difference\/time gap) of PHE shape changes with 3-month modified Rankin Score (mRS) \u2013 using Spearman correlation. Then, using multivariable analysis, we determined if PHE shape features independently predict outcome adjusting for patients\u2019 age, sex, NIH stroke scale (NIHSS), Glasgow Coma Scale (GCS), and hematoma volume.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Baseline PHE maximum diameters across various planes, main axes, volume, surface, and sphericity correlated with 3-month mRS adjusting for multiple comparisons. The 24-h difference and temporal change rates of these features had significant association with outcome \u2013 but not the 24-h absolute values. In multivariable regression, baseline PHE shape sphericity (OR\u2009=\u20092.04, CI\u2009=\u20091.71\u20132.43) and volume (OR\u2009=\u20090.99, CI\u2009=\u20090. 98\u20131.0), alongside admission NIHSS (OR\u2009=\u20090.86, CI\u2009=\u20090.83\u20130.88), hematoma volume (OR\u2009=\u20090.99, CI\u2009=\u20090. 99\u20131.0), and age (OR\u2009=\u20090.96, CI\u2009=\u20090.95\u20130.97) were independent predictors of favorable outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In acute ICH patients, PHE shape sphericity at baseline emerged as an independent prognostic factor, with a less spherical (more irregular) shape associated with worse outcome. The PHE shape features absolute values over the first 24\u2009h provide no added prognostic value to baseline metrics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/23969873231223814","type":"journal-article","created":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T05:34:58Z","timestamp":1704432898000},"page":"383-390","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Peri-hematomal edema shape features related to 3-month outcome in acute supratentorial intracerebral hemorrhage"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1913-0603","authenticated-orcid":false,"given":"Fiona","family":"Dierksen","sequence":"first","affiliation":[{"name":"Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA 1"},{"name":"Department of Neurology, Georg-August University G\u00f6ttingen, G\u00f6ttingen, Germany 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anh T","family":"Tran","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tal","family":"Zeevi","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6988-8878","authenticated-orcid":false,"given":"Ilko L","family":"Maier","sequence":"additional","affiliation":[{"name":"Department of Neurology, Georg-August University G\u00f6ttingen, G\u00f6ttingen, Germany 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan I","family":"Qureshi","sequence":"additional","affiliation":[{"name":"Zeenat Qureshi Stroke Institute and Department of Neurology, University of Missouri, Columbia, MO, USA 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pina C","family":"Sanelli","sequence":"additional","affiliation":[{"name":"Department of Feinstein Institute for Medical Research, Manhasset, NY, USA 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J","family":"Werring","sequence":"additional","affiliation":[{"name":"Stroke Research Centre, University College London, Queen Square Institute of Neurology, London, UK 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Malhotra","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido J","family":"Falcone","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yale School of Medicine, New Haven, CT, USA 6"},{"name":"Center for Brain & Mind Health, Yale School of Medicine, New Haven, CT, USA 7"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin N","family":"Sheth","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yale School of Medicine, New Haven, CT, USA 6"},{"name":"Center for Brain & Mind Health, Yale School of Medicine, New Haven, CT, USA 7"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyedmehdi","family":"Payabvash","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yale School of Medicine, New Haven, CT, USA 6"},{"name":"Center for Brain & Mind Health, Yale School of Medicine, New Haven, CT, USA 7"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,6,1]]},"reference":[{"key":"2026012113094021100_bibr1-23969873231223814","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1161\/STROKEAHA.115.009185","article-title":"Blend sign on computed tomography: novel and reliable predictor for early hematoma growth in patients with intracerebral hemorrhage","volume":"46","author":"Li","year":"2015","journal-title":"Stroke"},{"key":"2026012113094021100_bibr2-23969873231223814","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1136\/jnnp-2012-303160","article-title":"Volume-dependent effect of perihaematomal oedema on outcome for spontaneous intracerebral haemorrhages","volume":"84","author":"Appelboom","year":"2013","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2026012113094021100_bibr3-23969873231223814","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1136\/jnnp-2016-313653","article-title":"Rate of perihaematomal oedema expansion is associated with poor clinical outcomes in intracerebral haemorrhage","volume":"87","author":"Murthy","year":"2016","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2026012113094021100_bibr4-23969873231223814","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1161\/STROKEAHA.110.590646","article-title":"Natural history of perihematomal edema after intracerebral hemorrhage measured by serial magnetic resonance imaging","volume":"42","author":"Venkatasubramanian","year":"2011","journal-title":"Stroke"},{"key":"2026012113094021100_bibr5-23969873231223814","first-page":"22","article-title":"Artificial intelligence-driven radiomics study in cancer: the role of feature engineering and modeling","volume":"10","author":"Zhang","year":"2023","journal-title":"Mil Med Res"},{"key":"2026012113094021100_bibr6-23969873231223814","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1056\/NEJMoa1603460","article-title":"Intensive blood-pressure lowering in patients with acute cerebral hemorrhage","volume":"375","author":"Qureshi","year":"2016","journal-title":"N Engl J Med"},{"key":"2026012113094021100_bibr7-23969873231223814","doi-asserted-by":"crossref","first-page":"e104","DOI":"10.1158\/0008-5472.CAN-17-0339","article-title":"Computational radiomics system to decode the radiographic phenotype","volume":"77","author":"van Griethuysen","year":"2017","journal-title":"Cancer Res"},{"key":"2026012113094021100_bibr8-23969873231223814","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1177\/17474930211050749","article-title":"The coronal plane maximum diameter of deep intracerebral hemorrhage predicts functional outcome more accurately than hematoma volume","volume":"17","author":"Haider","year":"2022","journal-title":"Int J Stroke"},{"key":"2026012113094021100_bibr9-23969873231223814","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.1111\/ene.15000","article-title":"Admission computed tomography radiomic signatures outperform hematoma volume in predicting baseline clinical severity and functional outcome in the ATACH-2 trial intracerebral hemorrhage population","volume":"28","author":"Haider","year":"2021","journal-title":"Eur J Neurol"},{"key":"2026012113094021100_bibr10-23969873231223814","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2023.1225342","article-title":"Radiomic markers of intracerebral hemorrhage expansion on non-contrast CT: independent validation and comparison with visual markers","volume":"17","author":"Haider","year":"2023","journal-title":"Front Neurosci"},{"key":"2026012113094021100_bibr11-23969873231223814","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1111\/j.1468-1331.2011.03395.x","article-title":"Semi-automatic volumetric assessment of perihemorrhagic edema with computed tomography","volume":"18","author":"Volbers","year":"2011","journal-title":"Eur J Neurol"},{"key":"2026012113094021100_bibr12-23969873231223814","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1161\/STROKEAHA.113.003194","article-title":"Cerebral perfusion and blood pressure do not affect perihematoma edema growth in acute intracerebral hemorrhage","volume":"45","author":"McCourt","year":"2014","journal-title":"Stroke"},{"key":"2026012113094021100_bibr13-23969873231223814","first-page":"196","article-title":"A Hounsfield value-based approach for automatic recognition of brain haemorrhage","volume":"3","author":"Phan","year":"2019","journal-title":"J Inf Telecommun"},{"key":"2026012113094021100_bibr14-23969873231223814","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.3174\/ajnr.A4393","article-title":"Early quantification of hematoma Hounsfield Units on noncontrast CT in acute intraventricular hemorrhage predicts ventricular clearance after intraventricular thrombolysis","volume":"36","author":"Kornbluth","year":"2015","journal-title":"Am J Neuroradiol"},{"key":"2026012113094021100_bibr15-23969873231223814","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1177\/23969873231157884","article-title":"The association between perihaematomal oedema and functional outcome after spontaneous intracerebral haemorrhage: a systematic review and meta-analysis","volume":"8","author":"Cliteur","year":"2023","journal-title":"Eur Stroke J"},{"key":"2026012113094021100_bibr16-23969873231223814","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000005167","article-title":"Peak perihemorrhagic edema correlates with functional outcome in intracerebral hemorrhage","volume":"90","author":"Volbers","year":"2018","journal-title":"Neurology"},{"key":"2026012113094021100_bibr17-23969873231223814","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1161\/STROKEAHA.114.007154","article-title":"Prognostic significance of perihematomal edema in acute intracerebral hemorrhage: pooled analysis from the intensive blood pressure reduction in acute cerebral hemorrhage trial studies","volume":"46","author":"Yang","year":"2015","journal-title":"Stroke"},{"key":"2026012113094021100_bibr18-23969873231223814","doi-asserted-by":"crossref","first-page":"4329","DOI":"10.1038\/s41598-019-40437-5","article-title":"The complexity of tumor shape, spiculatedness, correlates with tumor radiomic shape features","volume":"9","author":"Limkin","year":"2019","journal-title":"Sci Rep"},{"key":"2026012113094021100_bibr19-23969873231223814","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1002\/jnr.24372","article-title":"Perihematomal edema: implications for intracerebral hemorrhage research and therapeutic advances","volume":"98","author":"Selim","year":"2020","journal-title":"J Neurosci Res"},{"key":"2026012113094021100_bibr20-23969873231223814","article-title":"The clinical effect of deferoxamine mesylate on edema after intracerebral hemorrhage","volume":"10","author":"Yu","year":"2015","journal-title":"PLoS One"},{"key":"2026012113094021100_bibr21-23969873231223814","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1111\/ene.12140","article-title":"Effects of celecoxib on hematoma and edema volumes in primary intracerebral hemorrhage: a multicenter randomized controlled trial","volume":"20","author":"Lee","year":"2013","journal-title":"Eur J Neurol"},{"key":"2026012113094021100_bibr22-23969873231223814","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2022.101666","article-title":"Efficacy and safety of glibenclamide therapy after intracerebral haemorrhage (GATE-ICH): a multicentre, prospective, randomised, controlled, open-label, blinded-endpoint, phase 2 clinical trial","volume":"53","author":"Zhao","year":"2022","journal-title":"eClinicalMedicine"},{"key":"2026012113094021100_bibr23-23969873231223814","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/cpdd.795","article-title":"First-in-Human studies of MW01-6-189WH, a Brain-Penetrant, antineuroinflammatory small-molecule drug candidate: Phase 1 safety, tolerability, pharmacokinetic, and pharmacodynamic studies in healthy adult volunteers","volume":"10","author":"Van Eldik","year":"2021","journal-title":"Clin Pharmacol Drug Dev"},{"key":"2026012113094021100_bibr24-23969873231223814","first-page":"2022","article-title":"Biomarker and Edema Attenuation in IntraCerebral Hemorrhage (BEACH)","author":"Magid-Bernstein","journal-title":"Clinical Trial, Yale School of Medicine"},{"key":"2026012113094021100_bibr25-23969873231223814","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0215952","article-title":"Glibenclamide, a Sur1-Trpm4 antagonist, does not improve outcome after collagenase-induced intracerebral hemorrhage","volume":"14","author":"Wilkinson","year":"2019","journal-title":"PLoS One"},{"key":"2026012113094021100_bibr26-23969873231223814","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1161\/STROKEAHA.119.027657","article-title":"Deep learning for automated measurement of hemorrhage and perihematomal edema in supratentorial intracerebral hemorrhage","volume":"51","author":"Dhar","year":"2020","journal-title":"Stroke"},{"key":"2026012113094021100_bibr27-23969873231223814","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s12028-022-01512-4","article-title":"Perihematomal edema and clinical outcome after intracerebral hemorrhage: a systematic review and meta-analysis","volume":"37","author":"Marchina","year":"2022","journal-title":"Neurocrit Care"},{"key":"2026012113094021100_bibr28-23969873231223814","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1177\/2396987319848203","article-title":"Oedema extension distance in intracerebral haemorrhage: association with baseline characteristics and long-term outcome","volume":"4","author":"Hurford","year":"2019","journal-title":"Eur Stroke J"},{"key":"2026012113094021100_bibr29-23969873231223814","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1097\/CCM.0000000000001553","article-title":"Rate of perihematomal edema expansion predicts outcome after intracerebral hemorrhage","volume":"44","author":"Urday","year":"2016","journal-title":"Crit Care Med"}],"container-title":["European Stroke Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/23969873231223814","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/23969873231223814","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/esj\/article-pdf\/9\/2\/383\/64648850\/23969873231223814.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/esj\/article-pdf\/9\/2\/383\/64648850\/23969873231223814.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T18:10:30Z","timestamp":1769019030000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/esj\/article\/9\/2\/383\/8269003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,1]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,6,1]]}},"URL":"https:\/\/doi.org\/10.1177\/23969873231223814","relation":{},"ISSN":["2396-9873","2396-9881"],"issn-type":[{"value":"2396-9873","type":"print"},{"value":"2396-9881","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,6,1]]},"published":{"date-parts":[[2024,6,1]]}}}