{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:04:26Z","timestamp":1791893066930,"version":"4.3.4"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Stroke remains a major health concern globally, with oral anticoagulants widely prescribed for stroke prevention. The efficacy and safety of mechanical thrombectomy (MT) in anticoagulated patients with distal medium vessel occlusions (DMVO) are not well understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This retrospective analysis involved 1282 acute ischemic stroke (AIS) patients who underwent MT in 37 centers across North America, Asia, and Europe from September 2017 to July 2023. Data on demographics, clinical presentation, treatment specifics, and outcomes were collected. The primary outcomes were functional outcomes at 90\u2009days post-MT, measured by modified Rankin Scale (mRS) scores. Secondary outcomes included reperfusion rates, mortality, and hemorrhagic complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of the patients, 223 (34%) were on anticoagulation therapy. Anticoagulated patients were older (median age 78 vs 74\u2009years; p\u2009&amp;lt;\u20090.001) and had a higher prevalence of atrial fibrillation (77% vs 26%; p\u2009&amp;lt;\u20090.001). Their baseline National Institutes of Health Stroke Scale (NIHSS) scores were also higher (median 12 vs 9; p\u2009=\u20090.002). Before propensity score matching (PSM), anticoagulated patients had similar rates of favorable 90-day outcomes (mRS 0\u20131: 30% vs 37%, p\u2009=\u20090.1; mRS 0\u20132: 47% vs 50%, p\u2009=\u20090.41) but higher mortality (26% vs 17%, p\u2009=\u20090.008). After PSM, there were no significant differences in outcomes between the two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Anticoagulated patients undergoing MT for AIS due to DMVO did not show significant differences in 90-day mRS outcomes, reperfusion, or hemorrhage compared to non-anticoagulated patients after adjustment for covariates.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/23969873241249295","type":"journal-article","created":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T07:10:22Z","timestamp":1715325022000},"page":"896-906","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":34,"title":["Outcomes of mechanical thrombectomy in anticoagulated patients with acute distal and medium vessel stroke"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5208-8425","authenticated-orcid":false,"given":"Hamza","family":"Salim","sequence":"first","affiliation":[{"name":"Department of Radiology, Division of Neuroradiology, Johns Hopkins Medical Center, Baltimore, MD, USA 1"},{"name":"Neuroendovascular Program, Massachusetts General Hospital & Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4910-6090","authenticated-orcid":false,"given":"Basel","family":"Musmar","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Thomas Jefferson University, Philadelphia, PA, USA 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nimer","family":"Adeeb","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Interventional Neuroradiology, Louisiana State University, LA, USA 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Yedavalli","sequence":"additional","affiliation":[{"name":"Department of Radiology, Division of Neuroradiology, Johns Hopkins Medical Center, Baltimore, MD, USA 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7577-1887","authenticated-orcid":false,"given":"Dhairya","family":"Lakhani","sequence":"additional","affiliation":[{"name":"Department of Radiology, Division of Neuroradiology, Johns Hopkins Medical Center, Baltimore, MD, USA 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahibjot Singh","family":"Grewal","sequence":"additional","affiliation":[{"name":"Neurovascular Centre, Divisions of Therapeutic Neuroradiology and Neurosurgery, St. Michael Hospital, University of Toronto, Toronto, ON, Canada 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kareem","family":"El Naamani","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Thomas Jefferson University, Philadelphia, PA, USA 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Henninger","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA, USA 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sri Hari","family":"Sundararajan","sequence":"additional","affiliation":[{"name":"Department of Endovascular Neurosurgery and Neuroradiology NJMS, Newark, NJ, USA 7"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Luisa","family":"K\u00fchn","sequence":"additional","affiliation":[{"name":"Division of Neurointerventional Radiology, Department of Radiology, University of Massachusetts Medical Center, Worcester, MA, USA 8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Khalife","sequence":"additional","affiliation":[{"name":"Cooper Neurological Institute, Cooper University Hospital, Cooper Medical School of Rowen University, Camden, NJ, USA 9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherief","family":"Ghozy","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery & Radiology, Mayo Clinic, Rochester, MN, USA 10"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1316-0383","authenticated-orcid":false,"given":"Luca","family":"Scarcia","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Henri Mondor Hospital, Creteil, France 11"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin YQ","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 12"},{"name":"Division of Neurology, Department of Medicine, National University Hospital, Singapore 13"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2958-3484","authenticated-orcid":false,"given":"Robert W","family":"Regenhardt","sequence":"additional","affiliation":[{"name":"Neuroendovascular Program, Massachusetts General Hospital & Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy J","family":"Heit","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology, Stanford Medical Center, Palo Alto, CA, USA 14"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole M","family":"Cancelliere","sequence":"additional","affiliation":[{"name":"Neurovascular Centre, Divisions of Therapeutic Neuroradiology and Neurosurgery, St. Michael Hospital, University of Toronto, Toronto, ON, Canada 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua D","family":"Bernstock","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston MA, USA 15"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aymeric","family":"Rouchaud","sequence":"additional","affiliation":[{"name":"Neuroradiology Department, Dupuytren, University Hospital of Limoges, Universit\u00e9 de Limoges, Limoges, France 16"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8533-7478","authenticated-orcid":false,"given":"Jens","family":"Fiehler","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany 17"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Sheth","sequence":"additional","affiliation":[{"name":"Department of Neurology, UTHealth McGovern Medical School, Houston, TX, USA 18"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajit S","family":"Puri","sequence":"additional","affiliation":[{"name":"Division of Neurointerventional Radiology, Department of Radiology, University of Massachusetts Medical Center, Worcester, MA, USA 8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Dyzmann","sequence":"additional","affiliation":[{"name":"Neuroradiology Department, Sana Kliniken, L\u00fcbeck GmbH, L\u00fcbeck, Germany 19"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Colasurdo","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology, Oregon Health and Science University, Portland, OR, USA 20"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Barreau","sequence":"additional","affiliation":[{"name":"Interventional Neuroradiology Department, Bordeaux University Hospital, Bordeaux, France 21"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Renieri","sequence":"additional","affiliation":[{"name":"Interventistica Neurovascolare, Ospedale Careggi di Firenze, Florence, Italy 22"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Pedro","family":"Filipe","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology, Centro Hospitalar Universit\u00e1rio do Porto, Porto, Portugal 23"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Harker","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Cincinnati Medical Center, Cincinnati, OH, USA 24"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6375-8466","authenticated-orcid":false,"given":"R\u0103zvan Alexandru","family":"Radu","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Gui de Chauliac Hospital, Montpellier University Medical Center, France 25"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Abdalkader","sequence":"additional","affiliation":[{"name":"Departments of Radiology & Neurology, Boston Medical Center, Boston, MA, USA 26"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7468-137X","authenticated-orcid":false,"given":"Piers","family":"Klein","sequence":"additional","affiliation":[{"name":"Departments of Radiology & Neurology, Boston Medical Center, Boston, MA, USA 26"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas R","family":"Marotta","sequence":"additional","affiliation":[{"name":"Neurovascular Centre, Divisions of Therapeutic Neuroradiology and Neurosurgery, St. Michael Hospital, University of Toronto, Toronto, ON, Canada 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Spears","sequence":"additional","affiliation":[{"name":"Neurovascular Centre, Divisions of Therapeutic Neuroradiology and Neurosurgery, St. Michael Hospital, University of Toronto, Toronto, ON, Canada 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5108-6719","authenticated-orcid":false,"given":"Takahiro","family":"Ota","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan 27"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashkan","family":"Mowla","sequence":"additional","affiliation":[{"name":"Division of Stroke and Endovascular Neurosurgery, 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