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Secondary clinical efficacy outcomes include normalized change in National Institutes of Health Stroke Scale score from baseline to day 1, cognitive outcome at 90\u2009days, and health-related quality of life at 90\u2009days. Safety outcomes include all serious adverse events, symptomatic intracranial hemorrhage within 24\u2009h, and all-cause mortality up to 90\u2009days. Secondary imaging outcomes include successful reperfusion at end of EVT procedure and recanalization of target artery at 24\u2009h.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>DISTAL will inform physicians whether EVT in addition to BMT in people with AIS due to a MDVO is more efficacious than BMT alone.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/23969873241250212","type":"journal-article","created":{"date-parts":[[2024,5,4]],"date-time":"2024-05-04T00:34:58Z","timestamp":1714782898000},"page":"1083-1092","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":38,"title":["EnDovascular therapy plus best medical treatment (BMT) versus BMT alone for medIum distal veSsel occlusion sTroke (DISTAL): An international, multicentre, randomized-controlled, two-arm, assessor-blinded 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