{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:24:34Z","timestamp":1790706274790,"version":"4.1.0"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Medium vessel occlusion (MeVO) strokes, particularly affecting the M2 segment of the middle cerebral artery, represent a critical proportion of acute ischemic strokes, posing significant challenges in management and outcome prediction. The efficacy of mechanical thrombectomy (MT) in MeVO stroke may warrant reliable predictors of functional outcomes. This study aimed to investigate the prognostic value of follow-up infarct volume (FIV) for predicting 90-day functional outcomes in MeVO stroke patients undergoing MT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This multicenter, retrospective cohort study analyzed data from the Multicenter Analysis of primary Distal medium vessel occlusions: effect of Mechanical Thrombectomy (MAD-MT) registry, covering patients with acute ischemic stroke due to M2 segment occlusion treated with MT. We examined the relationship between 90-day functional outcomes, measured by the modified Rankin Scale (mRS), and follow-up infarct volume (FIV), assessed through CT or MRI within 12\u201336\u2009h post-MT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Among 130 participants, specific FIV thresholds were identified with high specificity and sensitivity for predicting outcomes. A FIV\u2009\u2a7d5\u2009ml was highly specific for predicting favorable and excellent outcomes. The optimal cut-off for both prognostications was identified at\u2009\u2a7d15\u2009ml by the Youden Index, with significant reductions in the likelihood of favorable outcomes observed above a 40\u2009ml threshold. Receiver Operator Curve (ROC) analyses confirmed FIV as a superior predictor of functional outcomes compared to traditional recanalization scores, such as final modified thrombolysis in cerebral infarction score (mTICI). Multivariable analysis further highlighted the inverse relationship between FIV and positive functional outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>FIV within 36\u2009h post-MT serves as a potent predictor of 90-day functional outcomes in patients with M2 segment MeVO strokes. Establishing FIV thresholds may aid in the prognostication of stroke outcomes, suggesting a role for FIV in guiding post intervention treatment decisions and informing clinical practice. Future research should focus on validating these findings across diverse patient populations and exploring the integration of FIV measurements with other clinical and imaging markers to enhance outcome prediction accuracy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/23969873241275531","type":"journal-article","created":{"date-parts":[[2024,9,14]],"date-time":"2024-09-14T00:31:29Z","timestamp":1726273889000},"page":"431-441","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Predictive value of follow-up infarct volume on functional outcomes in middle cerebral artery M2 segment vessel occlusion stroke treated with mechanical thrombectomy"],"prefix":"10.1093","volume":"10","author":[{"given":"Vivek","family":"Yedavalli","sequence":"first","affiliation":[{"name":"Department of Radiology, Division of Neuroradiology, Johns Hopkins Medical Center, Baltimore, MD, USA 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5208-8425","authenticated-orcid":false,"given":"Hamza Adel","family":"Salim","sequence":"additional","affiliation":[{"name":"Department of Radiology, Division of Neuroradiology, Johns Hopkins Medical Center, Baltimore, MD, USA 1"},{"name":"Neuroendovascular Program, Massachusetts General Hospital & Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA 2"},{"name":"Department of Neuroradiology, MD Anderson Medical Center, Houston, TX, USA 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4910-6090","authenticated-orcid":false,"given":"Basel","family":"Musmar","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Interventional Neuroradiology, Louisiana State University, LA, USA 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nimer","family":"Adeeb","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Interventional Neuroradiology, Louisiana State University, LA, USA 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kareem","family":"El Naamani","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Thomas Jefferson University, Philadelphia, PA, USA 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Henninger","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA, USA 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sri Hari","family":"Sundararajan","sequence":"additional","affiliation":[{"name":"Department of Endovascular Neurosurgery and Neuroradiology, NJMS, Newark, NJ, USA 7"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Luisa","family":"K\u00fchn","sequence":"additional","affiliation":[{"name":"Division of Neurointerventional Radiology, Department of Radiology, University of Massachusetts Medical Center, Worcester, MA, USA 8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Khalife","sequence":"additional","affiliation":[{"name":"Cooper Neurological Institute, Cooper University Hospital, Cooper Medical School of Rowen University, Camden, NJ, USA 9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherief","family":"Ghozy","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery & Radiology, Mayo Clinic, Rochester, MN, USA 10"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1316-0383","authenticated-orcid":false,"given":"Luca","family":"Scarcia","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Henri Mondor Hospital, Creteil, France 11"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin YQ","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 12"},{"name":"Division of Neurology, Department of Medicine, National University Hospital, Singapore 13"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2958-3484","authenticated-orcid":false,"given":"Robert W","family":"Regenhardt","sequence":"additional","affiliation":[{"name":"Neuroendovascular Program, Massachusetts General Hospital & Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy J","family":"Heit","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology, Stanford Medical Center, Palo Alto, CA, USA 14"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole M","family":"Cancelliere","sequence":"additional","affiliation":[{"name":"Divisions of Therapeutic Neuroradiology and Neurosurgery, Neurovascular Centre, St. Michael Hospital, University of Toronto, Toronto, ON, Canada 15"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua D","family":"Bernstock","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA 16"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aymeric","family":"Rouchaud","sequence":"additional","affiliation":[{"name":"Neuroradiology Department, University Hospital of Limoges, Dupuytren, Universit\u00e9 de Limoges, XLIM CNRS, UMR, France 17"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8533-7478","authenticated-orcid":false,"given":"Jens","family":"Fiehler","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery & Radiology, Mayo Clinic, Rochester, MN, USA 10"},{"name":"Department of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany 18"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Sheth","sequence":"additional","affiliation":[{"name":"Department of Neurology, UTHealth McGovern Medical School, Houston, TX, USA 19"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajit S","family":"Puri","sequence":"additional","affiliation":[{"name":"Division of Neurointerventional Radiology, Department of Radiology, University of Massachusetts Medical Center, Worcester, MA, USA 8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Dyzmann","sequence":"additional","affiliation":[{"name":"Neuroradiology Department, Sana Kliniken, L\u00fcbeck GmbH, L\u00fcbeck, Germany 20"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Colasurdo","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology, Oregon Health and Science University, Portland, OR, USA 21"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Barreau","sequence":"additional","affiliation":[{"name":"Interventional Neuroradiology Department, Bordeaux University Hospital, Bordeaux, France 22"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Renieri","sequence":"additional","affiliation":[{"name":"Interventistica Neurovascolare, Ospedale Careggi di Firenze, Florence, Italy 23"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Pedro","family":"Filipe","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology, Centro Hospitalar Universit\u00e1rio do Porto, Porto, Portugal 24"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Harker","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Cincinnati Medical Center, Cincinnati, OH, USA 25"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6375-8466","authenticated-orcid":false,"given":"R\u0103zvan Alexandru","family":"Radu","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Gui de Chauliac Hospital, Montpellier University Medical Center, France 26"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Abdalkader","sequence":"additional","affiliation":[{"name":"Departments of Radiology & Neurology, Boston Medical Center, Boston, MA, USA 27"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7468-137X","authenticated-orcid":false,"given":"Piers","family":"Klein","sequence":"additional","affiliation":[{"name":"Departments of Radiology & Neurology, Boston Medical Center, Boston, MA, USA 27"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas R","family":"Marotta","sequence":"additional","affiliation":[{"name":"Divisions of Therapeutic Neuroradiology and Neurosurgery, Neurovascular Centre, St. Michael Hospital, University of Toronto, Toronto, ON, Canada 15"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Spears","sequence":"additional","affiliation":[{"name":"Divisions of Therapeutic Neuroradiology and Neurosurgery, Neurovascular Centre, St. Michael Hospital, University of Toronto, Toronto, ON, Canada 15"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5108-6719","authenticated-orcid":false,"given":"Takahiro","family":"Ota","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan 28"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashkan","family":"Mowla","sequence":"additional","affiliation":[{"name":"Division of Stroke and Endovascular Neurosurgery, Department of Neurological Surgery, Keck School of Medicine, University of Southern California (USC), Los Angeles, CA, USA 29"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8965-2413","authenticated-orcid":false,"given":"Pascal","family":"Jabbour","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Thomas Jefferson University, Philadelphia, PA, USA 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arundhati","family":"Biswas","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Westchester Medical Center at New York Medical College, Valhalla, NY, USA 30"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Claren\u00e7on","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Paris, France 31"},{"name":"GRC BioFast., Sorbonne University, Paris VI, France 32"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E","family":"Siegler","sequence":"additional","affiliation":[{"name":"Cooper Neurological Institute, Cooper University Hospital, Cooper Medical School of Rowen University, Camden, NJ, USA 9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2810-1685","authenticated-orcid":false,"given":"Thanh N","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Departments of Radiology & Neurology, Boston Medical Center, Boston, MA, USA 27"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Varela","sequence":"additional","affiliation":[{"name":"Department of Neurology, Centro Hospitalar Universit\u00e1rio do Porto, Porto, Portugal 33"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Baker","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery and Montefiore-Einstein Cerebrovascular Research Lab, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA 34"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8325-2382","authenticated-orcid":false,"given":"Muhammed Amir","family":"Essibayi","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery and Montefiore-Einstein Cerebrovascular Research Lab, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA 34"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Altschul","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery and Montefiore-Einstein Cerebrovascular Research Lab, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA 34"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8277-6317","authenticated-orcid":false,"given":"Nestor R","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, USA 35"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5075-704X","authenticated-orcid":false,"given":"Markus A","family":"M\u00f6hlenbruch","sequence":"additional","affiliation":[{"name":"Sektion Vaskul\u00e4re und Interventionelle Neuroradiologie, Universit\u00e4tsklinikum Heidelberg, Heidelberg, Germany 36"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Costalat","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Gui de Chauliac Hospital, Montpellier University Medical Center, France 26"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Gory","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology, Nancy University Hospital, Nancy, France 37"},{"name":"INSERM U1254, IADI, Universit\u00e9 de Lorraine, Vandoeuvre-les-Nancy, France 38"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian Paul","family":"Stracke","sequence":"additional","affiliation":[{"name":"Department of Radiology, Interventional Neuroradiology Section, University Medical Center M\u00fcnster, M\u00fcnster, Germany 39"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Ali","family":"Aziz-Sultan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA 16"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantin","family":"Hecker","sequence":"additional","affiliation":[{"name":"Departments of Neurology & Neurosurgery, Christian Doppler Clinic, Paracelsus Medical University Salzburg, Salzburg, Austria 40"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamza","family":"Shaikh","sequence":"additional","affiliation":[{"name":"Cooper Neurological Institute, Cooper University Hospital, Cooper Medical School of Rowen University, Camden, NJ, USA 9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5109-8736","authenticated-orcid":false,"given":"David S","family":"Liebeskind","sequence":"additional","affiliation":[{"name":"Department of Neurology, UCLA Stroke Center, UCLA, Los Angeles, CA, USA 41"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Pedicelli","sequence":"additional","affiliation":[{"name":"UOSA Neuroradiologia Interventistica, Fondazione Policlinico Universitario A. Gemelli IRCCS Roma, Roma, Italy 42"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8080-3916","authenticated-orcid":false,"given":"Andrea M","family":"Alexandre","sequence":"additional","affiliation":[{"name":"UOSA Neuroradiologia Interventistica, Fondazione Policlinico Universitario A. Gemelli IRCCS Roma, Roma, Italy 42"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Illario","family":"Tancredi","sequence":"additional","affiliation":[{"name":"Department of Neurology, H\u00f4pital Civil Marie Curie, Charleroi, Belgium 43"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias D","family":"Faizy","sequence":"additional","affiliation":[{"name":"Department of Radiology, Neuroendovascular Program, University Medical Center M\u00fcnster, Germany 44"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwah","family":"Kalsoum","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Henri Mondor Hospital, Creteil, France 11"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Lubicz","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology, Erasme University Hospital, Brussels, Belgium 45"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aman B","family":"Patel","sequence":"additional","affiliation":[{"name":"Neuroendovascular Program, Massachusetts General Hospital & Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitor Mendes","family":"Pereira","sequence":"additional","affiliation":[{"name":"Divisions of Therapeutic Neuroradiology and Neurosurgery, Neurovascular Centre, St. Michael Hospital, University of Toronto, Toronto, ON, Canada 15"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrien","family":"Guenego","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology, Erasme University Hospital, Brussels, Belgium 45"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam A","family":"Dmytriw","sequence":"additional","affiliation":[{"name":"Neuroendovascular Program, Massachusetts General Hospital & Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA 2"},{"name":"Divisions of Therapeutic Neuroradiology and Neurosurgery, Neurovascular Centre, St. Michael Hospital, University of Toronto, Toronto, ON, Canada 15"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the MAD MT Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,6,1]]},"reference":[{"key":"2026012113081960900_bibr1-23969873241275531","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1136\/neurintsurg-2021-017321","article-title":"A review of endovascular treatment for medium vessel occlusion stroke","volume":"13","author":"Ospel","year":"2021","journal-title":"J Neurointerv Surg"},{"key":"2026012113081960900_bibr2-23969873241275531","doi-asserted-by":"crossref","first-page":"2872","DOI":"10.1161\/STROKEAHA.120.028956","article-title":"Distal Thrombectomy Summit Group. 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