{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:09:12Z","timestamp":1787242152877,"version":"build-2736575974"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016545","name":"Roche Diagnostics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016545","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002491","name":"Bristol-Myers Squibb","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016545","name":"Roche Diagnostics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016545","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002491","name":"Bristol-Myers Squibb","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>ARCADIA compared apixaban to aspirin for secondary stroke prevention in patients with cryptogenic stroke and atrial cardiopathy. One possible explanation for the neutral result is that biomarkers used did not optimally identify atrial cardiopathy. We examined the relationship between biomarker levels and subsequent detection of AF, the hallmark of atrial cardiopathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Patients were randomized if they met criteria for atrial cardiopathy, defined as P-wave terminal force\u2009&amp;gt;5000\u2009\u03bcV*ms in ECG lead V1 (PTFV1), NT-proBNP\u2009&amp;gt;250\u2009pg\/mL, or left atrial diameter index (LADI) \u2a7e3\u2009cm\/m2. For this analysis, the outcome was AF detected per routine care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of 3745 patients who consented to screening for atrial cardiopathy, 254 were subsequently diagnosed with AF; 96 before they could be randomized and 158 after randomization. In unadjusted analyses, ln(NT-proBNP) (RR per SD, 1.99; 95% CI, 1.85\u20132.13), PTFV1 (RR per SD, 1.15; 95% CI, 1.03\u20131.28) and LADI (RR per SD, 1.34; 95% CI, 1.20\u20131.50) were associated with AF. In a model containing all 3 biomarkers, demographics, and AF risk factors, age (RR per 10\u2009years, 1.24; 95% CI, 1.09\u20131.41), ln(NT-proBNP) (RR per SD, 1.88; 95% CI, 1.67\u20132.11) and LADI (RR per SD, 1.25; 95% CI, 1.14\u20131.37) were associated with AF. These three variables together had a c-statistic of 0.82 (95% CI, 0.79\u20130.85) but only modest calibration. Discrimination was attenuated in sensitivity analyses of patients eligible for randomization who may have been more closely followed for AF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Biomarkers used to identify atrial cardiopathy in ARCADIA were moderately predictive of subsequent AF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/23969873241276358","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T06:35:43Z","timestamp":1724999743000},"page":"495-501","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Atrial cardiopathy biomarkers and atrial fibrillation in the ARCADIA 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4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WT","family":"Longstreth","sequence":"additional","affiliation":[{"name":"Neurology, University of Washington, Seattle, WA, USA 5"},{"name":"Medicine, University of Washington, Seattle, WA, USA 6"},{"name":"Epidemiology, University of Washington, Seattle, WA, USA 7"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Plummer","sequence":"additional","affiliation":[{"name":"Department of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA 8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebeca","family":"Aragon Garcia","sequence":"additional","affiliation":[{"name":"Department of Neurology, Columbia University, New York, NY, USA 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph P","family":"Broderick","sequence":"additional","affiliation":[{"name":"Department of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA 8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Pauls","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, USA 9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan J","family":"Elm","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, USA 9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadi","family":"Nahab","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Pediatrics, Emory University, Atlanta, GA, USA 10"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L Scott","family":"Janis","sequence":"additional","affiliation":[{"name":"National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, 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