{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T07:15:05Z","timestamp":1779002105534,"version":"3.51.4"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Bando Ricerca Corrente"},{"name":"Bando Ricerca Corrente"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Data on safety and efficacy of endovascular thrombectomy (EVT) for acute ischemic stroke in older patients are limited and controversial, and people aged 80 or older were under-represented in randomized trials. Our aim was to assess EVT effect for ischemic stroke patients aged\u2009\u2a7e80 at a nationwide level.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods:<\/jats:title>\n                    <jats:p>The cohort included stroke patients undergoing EVT from the Italian Registry of Endovascular Treatment in Acute Stroke (IRETAS). Patients were a priori divided into younger and older groups (&amp;lt;80 vs\u2009\u2a7e80). Primary outcome was good functional outcome (modified Rankin scale, mRS, 0\u20132 at 90\u2009days). Secondary outcomes were symptomatic intracranial hemorrhage (sICH), successful reperfusion, EVT abortion. Propensity score matching (PSM) was performed between age groups for baseline features, functional status, stroke severity and neuroradiological features. Logistic regression was implemented to test the weight of age group on the predefined outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Overall, 5872 individuals (1:1 matching, n\u2009=\u20092936 aged\u2009\u2a7e80 vs n\u2009=\u20092936\u2009&amp;lt;\u200980) were matched from 13,922 records. In\u2009\u2a7e80 group 34.1% had good functional outcome, vs 51.2% in\u2009&amp;lt;80 group (absolute difference\u2009=\u2009\u221217.1%, p\u2009&amp;lt;\u20090.001), with a 4.4% excess in EVT abortion. Age \u2a7e80 was a negative independent predictor of good functional outcome (aOR\u2009=\u20090.4, 95% CI\u2009=\u20090.3\u20130.5), but had no impact on sICH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion and conclusion:<\/jats:title>\n                    <jats:p>Age \u2a7e80\u2009years represents a consistent predictor of worse functional outcome, independently from successful reperfusion and sICH. Cost-effectiveness studies are needed for tailored and implement sustainable care, and research should focus on strategies to improve functional outcome in older age patient groups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/23969873241299335","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T08:18:42Z","timestamp":1732090722000},"page":"371-378","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Stroke thrombectomy in the elderly: A propensity score matched study on a nationwide real-world registry"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8009-8543","authenticated-orcid":false,"given":"Michele","family":"Romoli","sequence":"first","affiliation":[{"name":"Neurology and Stroke Unit, Department of Neurosciences, Bufalini Hospital, Cesena, Italy 1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludovica","family":"Migliaccio","sequence":"additional","affiliation":[{"name":"IRCCS Istituto delle Scienze Neurologiche di Bologna, UOC Neurologia e Rete Stroke Metropolitana, Bologna, Italy 2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9855-8894","authenticated-orcid":false,"given":"Valentina","family":"Saia","sequence":"additional","affiliation":[{"name":"Neurology and Stroke Unit, Santa Corona Hospital, Pietra Ligure (SV), Italy 3"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Pracucci","sequence":"additional","affiliation":[{"name":"Universita degli Studi di Firenze, Florence, Italy 4"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Cirillo","sequence":"additional","affiliation":[{"name":"IRCCS Istituto delle Scienze Neurologiche di Bologna, UOC Neuroradiologia, Bologna, Italy 5"},{"name":"Dipartimento di Scienze Biomediche e Neuromotorie (DIBINEM), Universit\u00e0 di Bologna, Bologna, Italy 6"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Forlivesi","sequence":"additional","affiliation":[{"name":"IRCCS Istituto delle Scienze Neurologiche di Bologna, UOC Neurologia e Rete Stroke Metropolitana, Bologna, Italy 2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Romano","sequence":"additional","affiliation":[{"name":"Neuroradiology Unit, AOU S Giovanni di Dio e Ruggi di Aragona, Salerno, Italy 7"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4099-8875","authenticated-orcid":false,"given":"Ilaria","family":"Casetta","sequence":"additional","affiliation":[{"name":"Neurology Unit, University Hospital Arcispedale S. Anna, Ferrara, Italy 8"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Fainardi","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Biomediche, Sperimentali e Cliniche, Neuroradiologia, Universit\u00e0 degli Studi di Firenze, Ospedale Universitario Careggi, Firenze, Italy 9"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Sallustio","sequence":"additional","affiliation":[{"name":"Unit\u00e1 di Trattamento Neurovascolare, ospedale dei Castelli-ASL6, Roma, Italy 10"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Limbucci","sequence":"additional","affiliation":[{"name":"Interventional Neurovascular Unit, Careggi University Hospital, Florence, Italy 11"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Nencini","sequence":"additional","affiliation":[{"name":"Stroke Unit, Azienda Ospedaliero Univarsitaria Careggi, Firenze, Italy 12"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerio","family":"Da Ros","sequence":"additional","affiliation":[{"name":"Dipartimento di Biomedicina e Prevenzione -uosd radiologia interventistica, Tor Vergata, Rome, Italy 13"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Diomedi","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy 14"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Vallone","sequence":"additional","affiliation":[{"name":"UO Neuroradiologia, Ospedale Civile di Baggiovara - AOU di Modena, Modena, Italy 15"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Bigliardi","sequence":"additional","affiliation":[{"name":"Neurologia-Stroke Unit, Ospedale Civile di Baggiovara - AOU di Modena, Modena, Italy 16"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio Lucio","family":"Vinci","sequence":"additional","affiliation":[{"name":"Neuroradiology Unit - Department of Biomedical, Dental, Morphological and Functional Imaging Sciences - University of Messina, Italy 17"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolino","family":"La Spina","sequence":"additional","affiliation":[{"name":"UOSD Stroke Unit, AOU \u201cG. 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