{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:54:52Z","timestamp":1789779292739,"version":"4.0.1"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"National Key Research and Development Program of China"},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82071468"],"award-info":[{"award-number":["82071468"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82271507"],"award-info":[{"award-number":["82271507"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82071468"],"award-info":[{"award-number":["82071468"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82271507"],"award-info":[{"award-number":["82271507"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Accurate diagnosis of cerebral amyloid angiopathy (CAA) in surviving patients is indispensable for making treatment decisions and conducting clinical trials. We aimed to evaluate the diagnostic value and clinical utility of the simplified Edinburgh computed tomography (CT) criteria for CAA-related hemorrhage in Chinese patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We analyzed 212 patients with lobar hemorrhage who underwent brain CT and magnetic resonance imaging (MRI) from a multicentre cohort. Using the Boston criteria version 2.0 (v2.0) as the gold standard, we assessed the application value of the simplified Edinburgh CT criteria, and investigated whether the Edinburgh CT criteria predict patient outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Patients with probable CAA accounted for 36.6% according to the Boston criteria v2.0. The Edinburgh CT criteria indicated an area under the receiver operating characteristic curves (AUC) of 0.735 for the diagnosis of probable CAA, and it performed better when there was a high-risk threshold of CAA in the decision curve analysis. Patients with a high risk of CAA based on the Edinburgh CT criteria had poorer outcomes at 90-day after adjusting for confounding factors (p\u2009=\u20090.034). Finger-like projections in the Edinburgh CT criteria were associated with lobar microbleeds, cortical superficial siderosis, and multispot white matter hyperintensity according to the Boston criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Taking the Boston criteria v2.0 as the gold standard, the Edinburgh CT criteria demonstrated good diagnostic value and predicted outcomes well at 90-day in Chinese patients with lobar hemorrhage. Further studies with larger sample sizes are required to confirm these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/23969873241309513","type":"journal-article","created":{"date-parts":[[2025,1,19]],"date-time":"2025-01-19T09:30:27Z","timestamp":1737279027000},"page":"1373-1382","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical diagnosis of cerebral amyloid angiopathy related hemorrhage in China: Simplified Edinburgh criteria and Boston criteria version 2.0"],"prefix":"10.1093","volume":"10","author":[{"given":"Mengke","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiwen","family":"Che","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing ShiJiTan hospital, Capital Medical University, Beijing, China 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengbei","family":"Hou","sequence":"additional","affiliation":[{"name":"Center for Evidence-Based Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyue","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Henan Province People\u2019s Hospital, Henan, China 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sen","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Medical Records, Henan Province People\u2019s Hospital, Henan, China 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengqi","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Neurology, People\u2019s Hospital of Zhengzhou, Henan, China 7"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Kan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailiang","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Fengtai You`anmen Hospital, Beijing, China 8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianmin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Fengtai You`anmen Hospital, Beijing, China 9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiliang","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Fengtai You`anmen Hospital, Beijing, China 9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijie","family":"Li","sequence":"additional","affiliation":[{"name":"Emergency Department, Xuanwu Hospital, Capital Medical University, Beijing, China 10"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changhong","family":"Ren","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hypoxia Conditioning Translational Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China 11"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbo","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Fengtai You`anmen Hospital, Beijing, China 9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanjie","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0293-2744","authenticated-orcid":false,"given":"Xunming","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China 12"},{"name":"Beijing Institute 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