{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T03:36:07Z","timestamp":1783568167719,"version":"3.55.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100013263","name":"Nasjonalforeningen for Folkehelsen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013263","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019902","name":"Fakultet for medisin og helsevitenskap, Norges Teknisk-Naturvitenskapelige Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019902","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Stroke Journal"],"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Long-term adherence to secondary prevention after ischemic stroke remains unclear. This study aimed to evaluate medication adherence, attainment of vascular treatment targets, and clinical characteristics that influence target achievement 3\u2009years post-stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods:<\/jats:title>\n                    <jats:p>\n                      We included 665 home-dwelling ischemic stroke patients from the Norwegian Cognitive Impairment After Stroke study, admitted between May 2015 and March 2017 (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u2009431 were followed for 3\u2009years). Medication adherence was assessed using the 4-item Morisky Medication Adherence Scale, medication persistence, and guideline-based treatment targets: blood pressure (BP)\u2009&lt;\u2009140\/90\u2009mmHg, LDL cholesterol (LDL-C)\u2009&lt;\u20092.0\u2009mmol\/L, and hemoglobin A1c (HbA1c)\u2009\u2a7d\u200953\u2009mmol\/mol.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>At discharge, prescription rates were 97% for antithrombotics, 67% for antihypertensives, 88% for lipid-lowering drugs (LLD), and 10% for antidiabetics. Three years later, persistence rates were 97%, 91%, 83%, and 94%, respectively, with 73% reporting high medication adherence. Target achievement rates were 42% for BP, 47% for LDL-C, and 75% for HbA1c among diabetic patients. Younger age was associated with better BP control (OR 0.974 per year, 95% CI\u20090.957\u20130.992). Women had poorer LDL-C control (OR 0.55, 95% CI\u20090.33\u20130.91). More LLD (OR 1.25, 95% CI\u20091.14\u20131.37) and higher comorbidity (OR 1.26, 95% CI\u20091.10\u20131.44) were associated with improved LDL-C control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Control of risk factors remained unsatisfactory 3\u2009years after ischemic stroke, despite relatively high persistence and adherence rates. Improved focus on implementing optimal secondary prevention for Norwegian stroke patients is necessary.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/23969873251329210","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T03:17:17Z","timestamp":1750821437000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Three-year adherence to secondary prevention and vascular risk control after ischemic stroke"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6552-7839","authenticated-orcid":false,"given":"Erlend","family":"Fagerli","sequence":"first","affiliation":[{"name":"Department of Circulation and Medical Imaging, NTNU \u2013 Norwegian University of Science and Technology, Trondheim, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanne","family":"Ellekj\u00e6r","sequence":"additional","affiliation":[{"name":"Department of Neuromedicine and Movement Science, NTNU \u2013 Norwegian University of Science and Technology, Trondheim, Norway"},{"name":"Stroke Unit, Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olav","family":"Spigset","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway"},{"name":"Department of Clinical and Molecular Medicine, NTNU \u2013 Norwegian University of Science and Technology, Trondheim, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingvild","family":"Saltvedt","sequence":"additional","affiliation":[{"name":"Department of Neuromedicine and Movement Science, NTNU \u2013 Norwegian University of Science and Technology, Trondheim, Norway"},{"name":"Department of Geriatric Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8623-7911","authenticated-orcid":false,"given":"Mari Nordb\u00f8","family":"Gynnild","sequence":"additional","affiliation":[{"name":"Department of Circulation and Medical Imaging, NTNU \u2013 Norwegian University of Science and Technology, Trondheim, Norway"},{"name":"Stroke Unit, Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway"},{"name":"Clinic of Cardiology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,6,5]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.602615"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.007267"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.106.475525"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurjpc\/zwab050"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/2047487314546825"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-016-0387-z"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13161"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra050100"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/23969873231215629"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-018-1198-x"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.09.010"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-198601000-00007"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/109019819001700303"},{"key":"e_1_3_4_15_2","unstructured":"Helsedirektoratet. Norwegian guideline for treatment and rehabilitation in stroke Updated 2017. 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Norwegian Stroke Registry: Annual report 2023. Norwegian Stroke Registry; 2024. 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