{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T12:56:20Z","timestamp":1769086580242,"version":"3.49.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Patients with ischemic stroke or transient ischemic attack (TIA) and cancer face unique risks of recurrent ischemic events and bleeding. It is unclear whether this increased risk is present even in patients with minor ischemic stroke or transient ischemic attack (TIA) receiving dual antiplatelet therapy (DAPT). This study aimed to evaluate the impact of cancer on the short-term outcomes after DAPT in patients with non-cardioembolic minor ischemic stroke or high-risk TIA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods:<\/jats:title>\n                    <jats:p>This was a secondary analysis of the prospective multicentric READAPT study (NCT05476081), including patients with non-cardioembolic minor ischemic stroke (NIHSS\u2009\u2a7d\u20095) or high-risk TIA (ABCD2 \u2a7e4) who initiated DAPT within 48\u2009h of symptom onset. The primary effectiveness outcome was the 90-day risk of new ischemic stroke or other vascular events (TIA, myocardial infarction, death due to vascular causes). Secondary outcomes included 90-day mRS score distribution and all-cause mortality. The primary safety outcome was the 90-day risk of any bleeding, with secondary safety outcomes including 24-h hemorrhagic transformation. We used Inverse Probability Weighting to compare outcomes between patients with and without cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>From 2278 patients in the READAPT study cohort, we included 1561 patients (mean age 70.3\u2009\u00b1\u200911.7\u2009years; 65.4% males), of whom 206 (13.2%) had cancer, categorized as either active (27.7%) or in remission (72.3%). After weighting, overall cancer patients had a higher risk of 90-day new ischemic stroke or other vascular events (weighted HR 1.78, 95% CI 1.20\u20132.63, p\u2009=\u20090.004) and worse 90-day mRS score distribution (OR 1.24, 95% CI 1.10\u20131.41, p\u2009&amp;lt;\u20090.001) compared to patients without cancer. The 90-day risk of bleeding did not differ between cancer and no-cancer groups overall. When analyzing cancer subgroups, patients with active cancer had significantly higher risk of 90-day ischemic stroke or other vascular (weighted HR 2.75, 95% CI 1.70\u20134.45, p\u2009&amp;lt;\u20090.001) and any bleeding (weighted HR 2.51, 95% CI 1.27\u20134.97, p\u2009=\u20090.008) events compared to no-cancer patients. In contrast, patients with cancer in remission had comparable risks to those without cancer. Furthermore, hematological malignancies were associated with a substantially higher risk of 90-day new ischemic stroke or other vascular events compared to solid tumors (weighted HR 8.15, 95% CI 5.06\u201313.14, p\u2009&amp;lt;\u20090.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Patients with minor ischemic stroke or high-risk TIA and active cancer have increased risk of ischemic and bleeding events after DAPT. Conversely, patients with cancer in remission have similar outcomes compared to those with no cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/23969873251333282","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T06:05:44Z","timestamp":1745388344000},"page":"1489-1501","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness and safety of dual antiplatelet therapy in patients with minor ischemic stroke or transient ischemic attack and cancer: A secondary analysis of the READAPT study"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0321-7155","authenticated-orcid":false,"given":"Matteo","family":"Foschi","sequence":"first","affiliation":[{"name":"Department of Biotechnological and Applied Clinical Sciences, University of L\u2019Aquila, L\u2019Aquila, Italy 1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8059-6427","authenticated-orcid":false,"given":"Federico","family":"De Santis","sequence":"additional","affiliation":[{"name":"Department of Biotechnological and Applied Clinical Sciences, University of L\u2019Aquila, L\u2019Aquila, Italy 1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4349-3322","authenticated-orcid":false,"given":"Lucio","family":"D\u2019Anna","sequence":"additional","affiliation":[{"name":"Department of Brain Sciences, Imperial College London, London, UK; Department of Stroke and Neuroscience, Charing Cross Hospital, Imperial College London NHS Healthcare Trust, London, UK 2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8009-8543","authenticated-orcid":false,"given":"Michele","family":"Romoli","sequence":"additional","affiliation":[{"name":"Stroke Unit, Maurizio Bufalini Hospital, Cesena, Italy 3"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiziana","family":"Tassinari","sequence":"additional","affiliation":[{"name":"Department of Neurology, Santa Corona Hospital, Pietra Ligure, Italy 4"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9855-8894","authenticated-orcid":false,"given":"Valentina","family":"Saia","sequence":"additional","affiliation":[{"name":"Department of Neurology, Santa Corona Hospital, Pietra Ligure, Italy 4"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Cenciarelli","sequence":"additional","affiliation":[{"name":"Department of Neurology, Citt\u00e0 di Castello Hospital, Citt\u00e0 di Castello, Italy 5"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Bedetti","sequence":"additional","affiliation":[{"name":"Department of Neurology, Citt\u00e0 di Castello Hospital, Citt\u00e0 di Castello, Italy 5"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Padiglioni","sequence":"additional","affiliation":[{"name":"Department of Neurology, Citt\u00e0 di Castello Hospital, Citt\u00e0 di Castello, Italy 5"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Censori","sequence":"additional","affiliation":[{"name":"Department of Neurology, ASST Ospedale Maggiore di Crema, Crema, Italy 6"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Puglisi","sequence":"additional","affiliation":[{"name":"Department of Neurology, ASST Ospedale Maggiore di Crema, Crema, Italy 6"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa","family":"Vinciguerra","sequence":"additional","affiliation":[{"name":"Department of Neurology, ASST Ospedale Maggiore di Crema, Crema, Italy 6"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Guarino","sequence":"additional","affiliation":[{"name":"IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy 7"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Barone","sequence":"additional","affiliation":[{"name":"IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy 7"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7530-818X","authenticated-orcid":false,"given":"Marialuisa","family":"Zedde","sequence":"additional","affiliation":[{"name":"Neurology Unit, Stroke Unit, AUSL-IRCCS di Reggio Emilia, Reggio Emilia, Italy 8"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaria","family":"Grisendi","sequence":"additional","affiliation":[{"name":"Neurology Unit, Stroke Unit, AUSL-IRCCS di Reggio Emilia, Reggio Emilia, Italy 8"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Diomedi","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine, Tor Vergata University, Rome, Italy 9"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Rosaria","family":"Bagnato","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine, Tor Vergata University, Rome, Italy 9"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Petruzzellis","sequence":"additional","affiliation":[{"name":"Stroke Unit, \u201cF. Puca\u201d AOU Consorziale Policlinico, Bari, Italy 10"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico Maria","family":"Mezzapesa","sequence":"additional","affiliation":[{"name":"Stroke Unit, \u201cF. Puca\u201d AOU Consorziale Policlinico, Bari, Italy 10"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Inchingolo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Casa sollievo della sofferenza, San Giovanni Rotondo, Italy 11"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Cappellari","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Verona 12"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Zivelonghi","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Verona 12"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Candelaresi","sequence":"additional","affiliation":[{"name":"Stroke Unit, AORN Antonio Cardarelli, Naples, Italy 13"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Andreone","sequence":"additional","affiliation":[{"name":"Stroke Unit, AORN Antonio Cardarelli, Naples, Italy 13"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Rinaldi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Di Venere Hospital, Bari, Italy 14"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Bavaro","sequence":"additional","affiliation":[{"name":"Department of Neurology, Di Venere Hospital, Bari, Italy 14"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5227-1502","authenticated-orcid":false,"given":"Anna Maria","family":"Cavallini","sequence":"additional","affiliation":[{"name":"Neurologia d\u2019Urgenza-Stroke Unit, IRCCS Mondino Foundation, Pavia, Italy 15"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Grazia","family":"Piscaglia","sequence":"additional","affiliation":[{"name":"Neurology Unit, S.Maria delle Croci Hospital, Ravenna, Italy 16"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Terruso","sequence":"additional","affiliation":[{"name":"Department of Neurology, AOOR Villa Sofia-Cervello, Palermo, Italy 17"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7683-7235","authenticated-orcid":false,"given":"Marina","family":"Mannino","sequence":"additional","affiliation":[{"name":"Department of Neurology, AOOR Villa Sofia-Cervello, Palermo, Italy 17"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Pezzini","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Parma, Parma, Italy; Stroke Care Program, Department of Emergencies, Parma University Hospital, Parma, Italy 18"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Frisullo","sequence":"additional","affiliation":[{"name":"Neuroscienze, Organi di Senso e Torace, Fondazione Policlinico Universitario Agostino Gemelli, Rome, Italy 19"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Muscia","sequence":"additional","affiliation":[{"name":"Department of Neurology, ASST-Ovest Milanese, Legnano, Italy 20"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5483-8795","authenticated-orcid":false,"given":"Maurizio","family":"Paciaroni","sequence":"additional","affiliation":[{"name":"Department of Internal and Cardiovascular Medicine-Stroke Unit, Santa Maria della Misericordia Hospital, Perugia, Italy 21"},{"name":"Unit of Clinical Neurology, Department of Neuroscience and Rehabilitation, University of Ferrara, Ferrara, Italy 22"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0456-9160","authenticated-orcid":false,"given":"Maria Giulia","family":"Mosconi","sequence":"additional","affiliation":[{"name":"Department of Internal and Cardiovascular Medicine-Stroke Unit, Santa Maria della Misericordia Hospital, Perugia, Italy 21"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Zini","sequence":"additional","affiliation":[{"name":"IRCCS Istituto delle Scienze Neurologiche di Bologna, Maggiore Hospital, Bologna, Italy 23"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruggiero","family":"Leone","sequence":"additional","affiliation":[{"name":"Stroke Unit, \u201cM. 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59"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Chiti","sequence":"additional","affiliation":[{"name":"Neurology Unit, Apuane Hospital, Massa Carrara, Italy 60"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcella","family":"Caggiula","sequence":"additional","affiliation":[{"name":"Department of Neurology, Vito Fazzi Hospital, Lecce, Italy 61"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maela","family":"Masato","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mirano Hospital, Italy 62"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Del Sette","sequence":"additional","affiliation":[{"name":"Neuroscience, IRCCS Ospedale Policlinico San Martino, Genoa, Italy 63"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Passarelli","sequence":"additional","affiliation":[{"name":"Department of Neurology, Fatebenefratelli 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