{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T01:56:45Z","timestamp":1773021405759,"version":"3.50.1"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Whether intravenous thrombolysis (IVT) provides additional benefit in eligible patients with acute vertebrobasilar occlusion who undergo endovascular treatment (EVT) remains an open question.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods:<\/jats:title>\n                    <jats:p>We conducted a pooled analysis using data from two national stroke registries, the ETIS registry in France and GSR-ET registry in Germany. Patients who underwent EVT for vertebral and\/or basilar artery occlusions from January 2015 to December 2023 were included. The primary efficacy outcome was a favorable shift toward better functional outcomes on modified Rankin Scale (mRS) scores at 90\u2009days. Safety outcomes included 90-days mortality and symptomatic haemorrhagic transformation (sICH). Comparisons between IVT\u2009+\u2009EVT and direct EVT groups were made combining inverse propensity score matching, probability of treatment weighting (IPTW) and regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Among 2028 patients treated during the study period, 797 (39.2%) received IVT before EVT, while 1231 (60.7%) had EVT alone. After IPTW matching, we compared 211 patients treated with IVT\u2009+\u2009EVT\u2009to\u2009260 direct EVT patients. Patients in the IVT\u2009+\u2009EVT group had a favorable shift across the 90-day mRS distribution (common aOR 1.43 per 1-point mRS improvement, 95% CI 1.01\u20132.04; p\u2009=\u20090.046), higher odds of 90-day favorable functional outcome (aOR 1.56, 95% CI 1.00\u20132.44; p\u2009=\u20090.049) and lower odds of 90-day mortality (aOR 0.62, 95% CI 0.39\u20130.99; p\u2009=\u20090.045). IVT was not associated with increased risk of sICH (aOR 1.65, 95% CI 0.62\u20134.35; p\u2009=\u20090.313).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>This registry-based study suggests a potential benefit of IVT before EVT in eligible patients with vertebrobasilar occlusions. Conclusion: Randomized clinical trials are necessary to confirm these findings and to validate the benefits of IVT in this clinical context.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/23969873251333652","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T09:49:26Z","timestamp":1744796966000},"page":"1354-1363","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Intravenous thrombolysis before endovascular treatment in acute vertebrobasilar occlusions: Pooled analysis of the French and German Stroke Registries"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4417-1496","authenticated-orcid":false,"given":"Raoul","family":"Pop","sequence":"first","affiliation":[{"name":"Department of Interventional Neuroradiology, Strasbourg University Hospitals, Strasbourg, France 1"},{"name":"Institut de Chirurgie Minime Invasive Guid\u00e9e par l\u2019Image, Strasbourg, France 2"},{"name":"INSERM UMR_S1255, Etablissement Fran\u00e7ais du Sang, Strasbourg, France 3"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanos","family":"Finitsis","sequence":"additional","affiliation":[{"name":"Ahepa Hospital, Aristotle University of Thessaloniki, Greece 4"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bertrand","family":"Lapergue","sequence":"additional","affiliation":[{"name":"Department of Neurology, Foch Hospital, Versailles Saint-Quentin en Yvelines University, Suresnes, France 5"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marek","family":"Sykora","sequence":"additional","affiliation":[{"name":"Department of Neurology, St. John\u2019s Hospital, Sigmund Freud University, Vienna, Austria 6"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9095-2344","authenticated-orcid":false,"given":"Daniel","family":"Strbian","sequence":"additional","affiliation":[{"name":"Department of Neurology, Helsinki University Hospital and University of Helsinki, Finland 7"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0108-9161","authenticated-orcid":false,"given":"Joshua","family":"Mbroh","sequence":"additional","affiliation":[{"name":"Department of Neurology & Stroke, University of T\u00fcbingen, T\u00fcbingen, Germany 8"},{"name":"Hertie Institute for Clinical Brain Research, University of T\u00fcbingen, T\u00fcbingen, Germany 9"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinchen","family":"Hui","sequence":"additional","affiliation":[{"name":"Department of Neurology & Stroke, University of T\u00fcbingen, T\u00fcbingen, Germany 8"},{"name":"Hertie Institute for Clinical Brain Research, University of T\u00fcbingen, T\u00fcbingen, Germany 9"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Hennersdorf","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology, University of T\u00fcbingen, T\u00fcbingen, Germany 10"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrike","family":"Ernemann","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology, University of T\u00fcbingen, T\u00fcbingen, Germany 10"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0286-8781","authenticated-orcid":false,"given":"Sven","family":"Poli","sequence":"additional","affiliation":[{"name":"Department of Neurology & Stroke, University of T\u00fcbingen, T\u00fcbingen, Germany 8"},{"name":"Hertie Institute for Clinical Brain Research, University of T\u00fcbingen, T\u00fcbingen, Germany 9"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Gory","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Therapeutic Neuroradiology, CHRU-Nancy, Nancy, France 11"},{"name":"Universit\u00e9 de Lorraine, Nancy, France 12"},{"name":"IADI, INSERM U1254, Nancy, France 13"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"On behalf of the ETIS and GSR-ET Investigators","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,12,1]]},"reference":[{"key":"2026012115065442600_bibr1-23969873251333652","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1056\/NEJMoa2207576","article-title":"Trial of thrombectomy 6 to 24 hours after stroke due to basilar-artery occlusion","volume":"387","author":"Jovin","year":"2022","journal-title":"N Engl J 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